Navigation Links
ATP is a key to feel warm temperature
Date:10/8/2009

A Japanese research group led by Prof. Makoto Tominaga and Dr. Sravan Mandadi (National Institute for Physiological Sciences: NIPS) found that ATP plays a key role in transmitting temperature information from skin keratinocytes to afferent sensory neurons. Their findings were presented in the Pflugers Archiv European Journal of Physiology published on October 2009.

Hazardous temperatures (extreme hot or cold) are known to be detected by the temperature-activated ion channels (thermoTRPs) expressed in free sensory nerve endings. On the other hand, ambient innocuous warm temperatures are sensed by different thermoTRPs, TRPV3 and TRPV4 expressed in skin keratinocytes. Interesting question is, therefore, how our nervous system recognizes the warmth information sensed by the non-excitable epithelial cells.

In a co-culture system, heat-evoked response in DRG neurons was secondary to that in skin keratinocytes, and the DRG responses were diminished by the ATP receptor antagonists. ATP release from keratinocytes was confirmed by 'a bio-sensor system' in which a cell expressing ATP receptors was placed in close proximity to keratinocytes. Warmth-activated TRPV3, rather than TRPV4, was found to be predominantly involved in the ATP release upon heating.

Dr. Tominaga said, "Our findings for the first time explains how ambient temperature information can be sent from skin to sensory nerves. Our results also support the emerging concept of ATP-mediated information transmission in the non-synaptic connections."


'/>"/>

Contact: Takaaki Sokabe
sokabe@nips.ac.jp
81-564-595-287
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists rebuild ancient proteins to reveal primordial Earths temperature
2. Scientists compiled 20th century temperature data in Spain as evidence of climatic change
3. From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
4. Fish with temperature-dependent sex determination face global warming
5. Turtles alter nesting dates due to temperature change says ISU researcher
6. Purdue study suggests warmer temperatures could lead to a boom in corn pests
7. Plants take a hike as temperatures rise
8. Making a point: Picoscale stability in a room-temperature AFM
9. Elevated water temperature and acidity boost growth of key sea star species: UBC researchers
10. Highest ever winter water temperatures recorded
11. NIST calculations may improve temperature measures for microfluidics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/21/2016)... -- Unique technology combines v ...   Xura, Inc. (NASDAQ: ... communications services, today announced it is working alongside SpeechPro ... particularly those in the Financial Services Sector, the ability ... a mobile app, alongside, and in combination with, traditional ...
(Date:3/15/2016)... -- --> --> According ... "Digital Door Lock Systems Market - Global Industry Analysis, Size, ... digital door lock systems market in terms of revenue was ... to grow at a CAGR of 31.8% during the period ... (MSMEs) across the world and high industrial activity driving inclusive ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Portland, Oregon (PRWEB) , ... May 25, 2016 ... ... Base Set features a variety of fracture-specific plating options designed to address fractures ... provide industry-leading fracture fixation solutions. , The Acumed Ankle Plating System 3 is ...
(Date:5/25/2016)... ... , ... Lady had been battling arthritis since the age of two and ... Lady’s owner Hannah sought the help of Dr Jeff Christiansen of Superior Veterinary ... ligament and help with the pain of Lady’s arthritis. Dr Christiansen suggested that in ...
(Date:5/24/2016)... ... 24, 2016 , ... Media Cybernetics, global image analysis leader, ... branding reflects a results-driven revitalization for a company with a renewed focus on ... a crisp, refreshed logo and a new web presence. , “I believe that ...
(Date:5/23/2016)... and LONDON , May 23, 2016 ... Could See Frontage Boost Efficiency by 40% - Frontage ... - Frontage Enforce Quality, Compliance and Traceability Within the Bioanalytical ... with labs in the United States and ... to be deployed across its laboratory facilities. In addition to ...
Breaking Biology Technology: