Navigation Links
ATP is a key to feel warm temperature
Date:10/8/2009

A Japanese research group led by Prof. Makoto Tominaga and Dr. Sravan Mandadi (National Institute for Physiological Sciences: NIPS) found that ATP plays a key role in transmitting temperature information from skin keratinocytes to afferent sensory neurons. Their findings were presented in the Pflugers Archiv European Journal of Physiology published on October 2009.

Hazardous temperatures (extreme hot or cold) are known to be detected by the temperature-activated ion channels (thermoTRPs) expressed in free sensory nerve endings. On the other hand, ambient innocuous warm temperatures are sensed by different thermoTRPs, TRPV3 and TRPV4 expressed in skin keratinocytes. Interesting question is, therefore, how our nervous system recognizes the warmth information sensed by the non-excitable epithelial cells.

In a co-culture system, heat-evoked response in DRG neurons was secondary to that in skin keratinocytes, and the DRG responses were diminished by the ATP receptor antagonists. ATP release from keratinocytes was confirmed by 'a bio-sensor system' in which a cell expressing ATP receptors was placed in close proximity to keratinocytes. Warmth-activated TRPV3, rather than TRPV4, was found to be predominantly involved in the ATP release upon heating.

Dr. Tominaga said, "Our findings for the first time explains how ambient temperature information can be sent from skin to sensory nerves. Our results also support the emerging concept of ATP-mediated information transmission in the non-synaptic connections."


'/>"/>

Contact: Takaaki Sokabe
sokabe@nips.ac.jp
81-564-595-287
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists rebuild ancient proteins to reveal primordial Earths temperature
2. Scientists compiled 20th century temperature data in Spain as evidence of climatic change
3. From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals
4. Fish with temperature-dependent sex determination face global warming
5. Turtles alter nesting dates due to temperature change says ISU researcher
6. Purdue study suggests warmer temperatures could lead to a boom in corn pests
7. Plants take a hike as temperatures rise
8. Making a point: Picoscale stability in a room-temperature AFM
9. Elevated water temperature and acidity boost growth of key sea star species: UBC researchers
10. Highest ever winter water temperatures recorded
11. NIST calculations may improve temperature measures for microfluidics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... 2017   Strategic Cyber Ventures , the industry,s ... a $3.5 million investment in  Polarity , the first ... is DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran ... this series A round of funding. This new funding ...
(Date:2/22/2017)... , Feb. 22, 2017 With the ... ABI Research identifies four technologies that innovative and ... secure significant share in the changing competitive landscape: ... passive authentication.   "Companies can no ... to security," says Dimitrios Pavlakis , Industry ...
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a community ... that it has received Laboratory Accreditation from the ... is presented to laboratories that meet stringent requirements ... scientifically rigorous processes. "Genos is committed ... laboratory practices. We,re honored to be receiving CAP ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... Arlington, VA (PRWEB) , ... March 29, 2017 ... ... a wearable patch comprising multiple separable adhesive layers, as issued by the U.S. ... adhesive layers as it applies to combining electronics and health monitoring. This invention ...
(Date:3/29/2017)... , March 29, 2017 "Surging application of ... by the government are expected to drive the growth ... The gesture recognition market is expected to be worth ... of 29.63% between 2017 and 2022. The touchless sensing ... by 2022, growing at a CAGR of 17.44% between ...
(Date:3/29/2017)... ... , ... ComplianceOnline, the leading governance, risk and compliance advisory network with over ... 2017 venue and speaker lineup. The Summit will take place on June 8 and ... Parker House Hotel, which is located at 60 School Street, Boston, MA will be ...
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... ... today that it is exhibiting in booth 513 at the Association of Community ... DC Downtown Hotel, March 29-31. , CANCERSCAPE unites key stakeholders from leading ...
Breaking Biology Technology: