Navigation Links
ASU researchers develop new device to help image key proteins at room temperature
Date:12/20/2013

TEMPE, Ariz. A group of researchers from Arizona State University are part of a larger team reporting a major advance in the study of human proteins that could open up new avenues for more effective drugs of the future. The work is being reported in this week's Science magazine.

In the paper, "Serial femtosecond crystallography of G-protein-coupled receptors," the team reports that they have been successful in imaging at room temperature the structure of G protein-coupled receptors (GPCR) with the use of an x-ray free-electron laser.

GPCR's are a highly diverse group of membrane proteins that mediate cellular communication. Because of their involvement in key physiological and sensory processes in humans, they are thought to be prominent drug targets.

The method described in the paper was applied for the first time to this important class of proteins, for which the 2012 Nobel Prize was awarded to Brian Kobilka and Robert Lefkowitz, said John Spence, an Arizona State University professor of physics. Spence also is the director of science at National Science Foundation's BioXFEL Science and Technology Center and a team member on the Science paper.

"These GPCR's are the targets of a majority of drug molecules," Spence said, but they are notoriously difficult to work with. This is the first time structural observations of the GPCR's have been made at room temperature, allowing researchers to overcome several disadvantages of previous imaging methods of the proteins.

"Normally, protein crystallography is performed on frozen samples, to reduce the effects of radiation damage," Spence said. "But this new work was based on an entirely new approach to protein crystallography, called SFX (Serial Femtosecond Crystallography) developed jointly by ASU, the Deutsches Elektronen-Synchrotron (DESY) and the SLAC National Accelerator Laboratory."

"This method uses brief pulses of x-rays instead of free
'/>"/>

Contact: Skip Derra
skip.derra@asu.edu
480-965-4823
Arizona State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
2. New anti-HIV drug target identified by University of Minnesota researchers
3. MU researchers develop advanced 3-dimensional force microscope
4. Researchers explain why some wound infections become chronic
5. Stanford researchers take a step toward developing a universal flu vaccine
6. Researchers engineer a hybrid 5 times more effective in delivering genetic material into cells
7. New organization brings together top researchers to sequence genomes of invertebrates
8. Bonefish spawning behavior in the Bahamas surprises researchers, should aid conservation
9. Where water is limited, researchers determine how much water is enough
10. Researchers at Penn help develop a dynamic model of tissue failure
11. Leibniz Prizes 2014: DFG honors 11 outstanding researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... ant Anoplolepis gracilipes is ranked amongst the top ... ecological impacts on islands. A new study published in the ... assesses the effects and dangers of the introduction of the ... palm forest of the Valle de Mai, a UNESCO World ... Valle de Mai is a unique ecosystem containing many endemic ...
(Date:7/9/2014)... Philadelphia, PA, July 10, 2014 Inflammatory diseases ... same patient, complicating treatment because a medication effective ... such example is the anti-arthritic medication dexamethasone, which ... disease. A study in the August issue of ... the effects of a new class of anti-arthritic ...
(Date:7/9/2014)... Bacteria found in the bladders of healthy women ... form of incontinence, according to researchers from Loyola ... These findings, published July 9, 2014, in the ... , suggest that bacterial communities may play a ... incontinence (UUI) is a common, yet poorly understood, ...
Breaking Biology News(10 mins):Invasion of yellow crazy ant in a Seychelles UNESCO palm forest: Threats and solutions 2New class of anti-arthritis drugs effectively treats multiple inflammatory diseases 2
... know - are drawing up gold particles from the earth via ... from CSIRO made the discovery and have published their findings in ... a hydraulic pump its roots extend tens of metres into ... gold is likely to be toxic to the plant, it,s moved ...
... , Oct. 23, 2013 Increasing awareness ... commercial biometrics market. While historically the adoption of ... recent years have witnessed considerable demand for applications ... finance. Iris and face recognition algorithms have undergone ...
... SALT LAKE CITYFor people with a family history of ... to 10 percent of colorectal cancers could be missed ... is the third most common cancer in the United ... population-based study to date, researchers from Huntsman Cancer Institute ...
Cached Biology News:There's gold in them thar trees 2Frost & Sullivan: Global Commercial Biometrics Market to Grow Considerably as Awareness Increases 2Frost & Sullivan: Global Commercial Biometrics Market to Grow Considerably as Awareness Increases 3Frost & Sullivan: Global Commercial Biometrics Market to Grow Considerably as Awareness Increases 4Colon cancer screening guidelines may miss 10 percent of colon cancers 2
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled ... 2pm EST (11am PST), “Natural Language Processing: Converting Raw ... technology can turn raw, heterogeneous data into actionable knowledge ... online webinar will last approximately one hour. , Synopsis: ...
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... In recent years, growing suspicion about ... product development and promotion has led to unprecedented levels ... by concerns about the insidious impact of commercialization of ... fines to the world’s biggest pharmas for illegal marketing ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Reportlinker.com announces that a new market research report ... Global Biotechnology Reagents Industry ... the worldwide markets for Biotechnology Reagents in US$ ... Reagents, DNA Sequencing/Synthesis Reagents, Electrophoresis Reagents, Flow Cytometry ...
... licensed within the next 4 years, as manufacturers are ... candidates in collaboration with health authorities and developing countries ... licensure, a team of leading scientists said. ... for regulatory review of dengue vaccines, while plans are ...
... from the University at Buffalo could lead to new solutions ... from drinking water. To the naked eye, both water ... are measured by the nanometer, a unit of length about ... , But at the microscopic level, the two actually differ ...
Cached Biology Technology:Reportlinker Adds Global Biotechnology Reagents Industry 2Capacity of developing country NRAs key to accelerated introduction of upcoming dengue vaccines 2Capacity of developing country NRAs key to accelerated introduction of upcoming dengue vaccines 3A nano-solution to global water problem: Nanomembranes could filter bacteria 2
... 20 years of expertise in the field ... offers the most powerful systems on the ... 40 000 in-microplate tests requiring incubation and ... different modules (such as worktable shaker incubators, ...
... or Isolated Sequence) siRNA Test System is ... evaluation of a potential of any DNA ... for RNA interference (RNAi). Current computer-based RNAi ... the probability of selected sequence to be ...
... pre-validated SNP sequencing services ... within 93 genes including ... more than 80 tyrosine ... were developed and validated ...
Glycerol-based mounting medium for immunofluorescence microscopy. Formulated to retard photobleaching of fluorochromes such as fluorescein and rhodamine. Product can also be used as a diluent for fl...
Biology Products: