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ASU receives 2-year, $5.3 million DARPA award to safeguard soldiers from infectious diseases
Date:9/14/2010

ng high-throughput technologies. This assortment acts as a sort of master tool kit, enabling researchers to rapidly construct a custom-tailored therapeutic against virtually any disease-associated protein.

The group has calculated that around 10,000 randomly constructed synbody components, made from short protein fragments called peptides, would provide sufficient variety to target virtually any biological threat. For the DARPA test however, the pool of synbodies can be dramatically reduced. "Our idea is to screen a large library of possible pathogens, identifying a broad class of effective binders, said assistant research professor Chris Diehnelt. "We would then produce stocks of peptides to be kept waiting in the wings, so that when we have a live fire test, the unknown pathogen can be screened to identifying several low binding affinity peptides. These we will rapidly assemble into a synbody, targeting that pathogen specifically."

The first test of their technology will come after the group's initial year of DARPA-funded research, at which time, the group will be presented with a pathogen and required to generate an effective therapeutic within 14 days. The second year goal of the project aims to cut the production time in half. The team estimates that an assortment of just 100 random peptide chains will be sufficient to screen a broad range of pathogen threats, with the certainty of finding multiple low-affinity chains, suitable for use in synbodies.

Completion of the current project will open the door to a new approach in the development of therapeutics to conquer one of the major challenges to human health.


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Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

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