Vernon is developing a technique that will use a type of gel to deliver the medicinal drugs. That would enable the injection of liquid medicinal materials into an aneurysm site. The materials then turn into a solid material that will more thoroughly fill up the aneurysm than platinum coils, and thus better prevent reforming of canals that would let blood resume flowing into the area.
He's also looking at how to make the injected materials gradually degrade unlike the coils so that no foreign material remains in the body perpetually and threatens to eventually cause complications.
At same time, he is working on enabling this method of treatment to also release a protein that will enhance and accelerate the growth of healthy protective tissue over aneurysms.
Post-doctoral bioengineering student Celeste Riley is assisting Vernon in the research.
Frakes also will work on methods to keep fluids from continuing to flow into aneurysms and cause potentially fatal ruptures. He'll develop experiments and simulations to study the effectiveness of applying various engineering techniques to predicting and controlling fluid dynamics (the behavior of fluids) in such preventative clinical treatments.
He expects the results to offer improved physical and computational models and methods for simulating fluid dynamics in treated brain aneurysms, as well as improved methods for measuring fluid behavior experimentally in treated physical cerebral aneurysm models.
His work will also provide improved computational models for new devices being developed to treat aneurysms.
Frakes will be assisted in the project by bioengineering doctoral students Priya Nair and Hiathem Babiker.
Vernon's research progress has drawn support from previous American Heart Association grants. Frakes' work has also attracted support from the Brain Aneurysm Foundation and the ASU Women in P
|Contact: Joe Kullman|
Arizona State University