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ASBMB Annual Meeting to feature talks on the biochemistry of aging
Date:4/17/2009

lerated aging and increased risks of cancer, have been valuable models. Niedernhofer and her lab have developed a mouse model that expresses sub-normal levels of ERCC1-XPF endonuclease, an enzyme that is important in DNA repair. Starting at 8 weeks of life, the mice display progressive symptoms associated with aging including muscle wasting, loss of vision and hearing, urinary incontinence, decreased liver and kidney function, and osteoporosis. These mice offer a great system to identify the mechanisms by which DNA damage can drive the tissue degeneration associated with aging as well as a platform to test anti-aging therapies like stem cells and free radical scavengers.


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Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

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