ASBMB Annual Meeting to feature talks on the biochemistr...(es in fly lifespan simply cannot be expe...)

Date:4/17/2009

es in fly lifespan simply cannot be expected to work in mammals. Kennedy and his group examined this issue by carefully analyzing age-related genes in yeast and the C. elegans worm, two organisms that diverged over a billion years ago. They found a statistically significant connection in the genes and pathways that affect aging in both organisms, including reduced mTOR signaling. They suggest that the conservation of aging genes across animals exists not because specific genes have evolved to regulate aging, but rather because animals have evolved a similar response to nutrient restriction, and lifespan is tightly linked to this response, providing evidence that efforts in humans just might work.

The Role of Insulin-like Signaling for the Central and Peripheral Regulation of Nutrient Homeostasis and Life Span
Morris White, Children's Hospital Boston, MA
(Tue, April 21 3:30 PM - 5:50 PM, Room: 356)

White will discuss some of his group's work in manipulating the levels of various insulin receptor substrates in mice. Insulin-like signaling regulates the storage and usage of nutrients, a process best exemplified by insulin's role in keeping blood glucose levels from getting too low or high; therefore proper insulin-like signaling is absolutely critical for growth and development. Interestingly, though, in lower animals like fruit flies and nematodes, reduced insulin secretion can extend lifespan. White will show some interesting studies suggesting that reduced insulin-like signaling in the brain can have a consistent effect in extending mammalian lifespan just as seen in worms and flies.

Cancer and Aging in DNA Repair Deficiency: Cause and Treatment
Laura J. Niedernhofer, University of Pittsburgh, PA
(Wed, April 22 12:50 PM - 3:10 PM, Room: 355)

Finding the keys to slow down aging requires a better understanding of the natural aging process. In that regard, progeroid syndromes, characterized by acce
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Contact: Nick Zagorski nzagorski@asbmb.org 301-634-7366 American Society for Biochemistry and Molecular Biology Source:Eurekalert

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