Navigation Links
ASBMB Annual Meeting to feature talks on the biochemistry of aging

Five-hundred years ago, Ponce de Leon combed the swamps of Florida seeking the legendary "fountain of youth." This week, at the 2009 ASBMB Annual Meeting in New Orleans (held in conjunction with Experimental Biology 2009) will feature a range of exciting talks centering on the new molecular "fountain of youth," the genes and pathways that influence lifespan. While the secrets of longevity may still be a long time away, the presentations at ASBMB illustrate that we are at least beginning to understand the intricate connections between diet, metabolism, aging, and disease.

Some of these aging-related presentations include:

Regulation of Obesity, Heart Function, and Lifespan by the Nutrient Sensing TOR Pathway
Sean Michael Oldham, Burnham Institute for Medical Research, La Jolla, CA
(Sun, April 19 3:30 PM - 5:50 PM, Room: 356)

Metabolic balance is a highly regulated process, and genetic and/or diet-induced imbalances (like a high fat diet, HFD) bring about increased susceptibility to obesity, diabetes, cardiovascular disease, and cancer. Oldham's group has established a fruit fly model to study the genes and environmental factors responsible for mediating HFD induced obesity. They found that inhibiting the Target of Rapamycin (TOR) pathway, involved in nutrient sensing, can block the detrimental effects of a HFD. They also found that reducing the levels of TOR can mimic a calorie-restricted diet and improve metabolism, heart function and longevity. Thus, in addition to potentially linking HFD-obesity to diabetes and heart disease, TOR might be a central mediator of lifespan.

Conserved Links Between Nutrient Signaling, Translation and Aging
Brian Kennedy, University of Washington, Seattle
(Wed, April 22 8:30 AM - 10:50 AM, Room: 356)

While model organisms like fruit flies have been invaluable in identifying hundreds of genes associated with aging, there is still concern that any increases in fly lifespan simply cannot be expected to work in mammals. Kennedy and his group examined this issue by carefully analyzing age-related genes in yeast and the C. elegans worm, two organisms that diverged over a billion years ago. They found a statistically significant connection in the genes and pathways that affect aging in both organisms, including reduced mTOR signaling. They suggest that the conservation of aging genes across animals exists not because specific genes have evolved to regulate aging, but rather because animals have evolved a similar response to nutrient restriction, and lifespan is tightly linked to this response, providing evidence that efforts in humans just might work.

The Role of Insulin-like Signaling for the Central and Peripheral Regulation of Nutrient Homeostasis and Life Span
Morris White, Children's Hospital Boston, MA
(Tue, April 21 3:30 PM - 5:50 PM, Room: 356)

White will discuss some of his group's work in manipulating the levels of various insulin receptor substrates in mice. Insulin-like signaling regulates the storage and usage of nutrients, a process best exemplified by insulin's role in keeping blood glucose levels from getting too low or high; therefore proper insulin-like signaling is absolutely critical for growth and development. Interestingly, though, in lower animals like fruit flies and nematodes, reduced insulin secretion can extend lifespan. White will show some interesting studies suggesting that reduced insulin-like signaling in the brain can have a consistent effect in extending mammalian lifespan just as seen in worms and flies.

Cancer and Aging in DNA Repair Deficiency: Cause and Treatment
Laura J. Niedernhofer, University of Pittsburgh, PA
(Wed, April 22 12:50 PM - 3:10 PM, Room: 355)

Finding the keys to slow down aging requires a better understanding of the natural aging process. In that regard, progeroid syndromes, characterized by accelerated aging and increased risks of cancer, have been valuable models. Niedernhofer and her lab have developed a mouse model that expresses sub-normal levels of ERCC1-XPF endonuclease, an enzyme that is important in DNA repair. Starting at 8 weeks of life, the mice display progressive symptoms associated with aging including muscle wasting, loss of vision and hearing, urinary incontinence, decreased liver and kidney function, and osteoporosis. These mice offer a great system to identify the mechanisms by which DNA damage can drive the tissue degeneration associated with aging as well as a platform to test anti-aging therapies like stem cells and free radical scavengers.


Contact: Nick Zagorski
American Society for Biochemistry and Molecular Biology

Related biology news :

1. ASBMB taps 8 scientists for top awards
2. Annual Michael & Susan Dell lectureship in child health
3. NAS annual meeting, April 25-28
4. Fifth annual Templeton-Cambridge fellowships awarded to 10 noted journalists
5. Phylonix to present at 2009 Society of Toxicology Annual Meeting
6. Society of Interventional Radiology hosts 34th annual scientific meeting
7. Register now for the Society of Interventional Radiologys 34th Annual Scientific Meeting
8. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
9. AIUM to Host 2009 Annual Convention in New York
10. Elsevier announces winners of 3rd Annual Scopus Young Indian Scientist Award
11. 17th Annual Congress on Womens Health convenes
Post Your Comments:
(Date:11/2/2015)... Calif. , Nov. 2, 2015  SRI International ... million to provide preclinical development services to the National ... contract, SRI will provide scientific expertise, modern testing and ... variety of preclinical pharmacology and toxicology studies to evaluate ... --> The PREVENT Cancer Drug Development Program ...
(Date:10/29/2015)... Oct. 29, 2015  The J. Craig Venter Institute ... "DNA Synthesis and Biosecurity: Lessons Learned and Options for ... Health and Human Services guidance for synthetic biology providers ... --> --> Synthetic ... the potential to pose unique biosecurity threats. It now ...
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... The ... newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent ... the last few years. Many AMA members have embraced this type of racing and ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... the remaining 11,000 post-share consolidation (or 1,100,000 pre-share ... "Series B Warrants") subject to the previously disclosed ... 23, 2015, which will result in the issuance ... to the issuance of such shares, there will ...
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh industrial processes, ... for in-line sensors can represent a weak spot where leaking process media is ... retractable sensor housings , which are designed to tolerate extreme process conditions. They ...
Breaking Biology Technology: