Navigation Links
ALS TDI and Gladstone Institutes collaborate to discover potential ALS treatments
Date:12/4/2012

CAMBRIDGE, MA and SAN FRANCISCO, CADecember 4, 2012 The ALS Therapy Development Institute (ALS TDI) and the Gladstone Institutes today announced the formation of a research collaboration to speed the discovery of potential treatments for ALS through the preclinical drug development process.

"We are thrilled about the potential this collaboration holds to accelerate ALS therapeutic development," said Steve Perrin, PhD, CEO and Chief Scientific Officer at ALS TDI. "Both our organizations have unique infrastructures, and by linking them this way, we may be able to advance potential treatments faster than before."

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disease that leads to paralysisand eventually deathdue to the loss of motor neurons in the spinal cord and brain. About 30,000 people in the United States live with the disease at any given time, and the global population of ALS patients is approximately 400,000. Approximately 5,000 new cases of ALS are diagnosed in the United States each year, and there is no known cause, cure or treatment to halt or reverse the disease. The average patient survives only two to five years following their diagnosis.

Under this new agreement, which starts immediately, Gladstone will evaluate potential pharmaceutical compounds using a human model of ALS. Gladstone generated the model by transforming skin cells from ALS patients into stem cells, known as induced pluripotent stem cells (iPS cells), and then programming them into neurons. The technique builds on a discovery for which Shinya Yamanaka, MD, PhD, a Gladstone senior investigator, won the 2012 Nobel Prize in Physiology or Medicine.

This particular iPS-based ALS model includes a gene mutation that produces TDP-43, a protein commonly found in most forms of ALS. Promising drug compounds that pass the initial evaluation process at Gladstone will be fast-tracked for pre-clinical testing a
'/>"/>

Contact: Diane Schrick
diane.schrick@gladstone.ucsf.edu
415-734-2538
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstone, Stanford scientists block toxic protein that plays key role in Lou Gehrigs disease
2. Gladstone scientists identify critical process in stem cell development
3. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
4. TGen leads new National Institutes of Health study of brain tumors
5. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
6. Astellas and DNDi to collaborate on new drug discovery research for the treatment of NTDs
7. BGI and Aspera collaborate on high-speed data exchange to advance genome research
8. HUNT Biosciences and SomaLogic collaborate to validate protein biomarkers of cardiovascular risk
9. American University biologist discovers new crab species
10. Hearty organisms discovered in bitter-cold Antarctic brine
11. Microbial missing link discovered after man impales hand on tree branch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... rating systems be used in supermarkets to encourage healthier ... sought to answer that very question by tracking the ... Guiding Stars System to rate the nutritional value of ... and Brand Lab,s David Just, PhD, and Brian Wansink ... sales records of over 150 Hannaford Supermarkets in the ...
(Date:8/19/2014)... this week,s Eos: Long-Term Ecological Research and Network-Level Science, ... how a wide range of ecosystems was responding to ... be particularly powerful if it coupled multiple decades of ... long-term experiments and models from dozens of different ecosystem ... is the Long-Term Ecological Research (LTER) Network, which will ...
(Date:8/19/2014)... many parts of the world, leprosy and tuberculosis ... cases of leprosy per year, with nearly all ... currently available century-old vaccine Bacille Calmette-Guerin, or BCG, ... leprosy, so a more potent vaccine is needed ... found a stronger weapon against both diseases., In ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2
... Efforts on the Growing Issue of Identity Management , ... WASHINGTON , July ... today announced that it has expanded its mission to focus on the ... biometric and other technologies play an increasingly important role, has been deemed ...
... Having discovered a dramatic increase of an easy-to-detect enzyme ... prediabetes, Johns Hopkins scientists say the discovery could lead to ... the disease, before symptoms or complications occur and in time ... 22 in Diabetes , show the enzyme O-GlcNAcase is ...
... 8, 2010 A new system for the controlled ... team of University of Rhode Island chemical engineers using ... by non-invasive electromagnetic fields. The discovery by URI ... Yanjing Chen was published in the June issue of ...
Cached Biology News:The International Biometrics & Identification Association (IBIA) Sets New Course to Benefit Consumers, Businesses and Governments Across the Globe 2The International Biometrics & Identification Association (IBIA) Sets New Course to Benefit Consumers, Businesses and Governments Across the Globe 3Hopkins team discovers sweet way to detect prediabetes 2Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field 2
(Date:8/20/2014)... measuring vibrational motion of a single molecule with a ... a single molecule differs from the behaviour of larger ... the University of California, Irvine, where post-doctoral researcher Eero ... visiting fellow under professor Vartkess A. Apkarian, whose team ... by Professor Eric O. Potma. The results of the ...
(Date:8/20/2014)... -- PAREXEL International Corporation (NASDAQ: PRXL ) announced ... Healthcare Conference in New York.  Ingo Bank , ... making a presentation on PAREXEL and discussing business developments ... A live webcast of the discussion will ... at www.PAREXEL.com in the Upcoming Events portion ...
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
Breaking Biology Technology:Seeing a molecule breathe 2PAREXEL International To Present At Baird Healthcare Conference 2'Tickling' your ear could be good for your heart 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... eleventh-annual and largest-ever Venture Forum was held two weeks ... 130 technology companies to an audience of several hundred ... be of particular interest to Midwest technology entrepreneurs as ... too. , ,The forum is organized by the Larta ...
... there is no shortage of vendors who want to be your ... the right Web developer, Web designer, or interactive media company to ... want to be sure that the company can do the work ... process, and maintains an adequate level of attention to your project. ...
... remains optimistic that his bill requiring notification of ... this year. , ,Senate Bill 164, co-authored ... would require companies that keep personal data on ... that data is obtained by unauthorized parties. Kanavas ...
Cached Biology Technology:Midwest fares surprisingly well at Venture Forum in Los Angeles 2Midwest fares surprisingly well at Venture Forum in Los Angeles 3Midwest fares surprisingly well at Venture Forum in Los Angeles 4The best and the rest: rating Web developers 2The best and the rest: rating Web developers 3The best and the rest: rating Web developers 4Kanavas thinks personal ID theft bill will pass this year 2
...
... system and disposable ESI Chip allow users ... of electrospray mass spectrometers for life science ... users to either speed analysis for increased ... applications, or long acquisition times for proteomics ...
... ABsolute QPCR SYBR Green Mixes are optimised for ... components necessary to perform Quantitative PCR, with the ... SYBR Green Mix contains optimal levels of active ... supplied in a proprietary reaction buffer that enables ...
Rabbit polyclonal to Vitronectin ( Abpromise for all tested applications). Antigen: Full length Vitronectin protein (Mouse). Entrez Gene ID: 7448 Swiss Protein ID: P04004...
Biology Products: