Navigation Links
ACS Green Chemistry Institute Pharmaceutical Roundtable award goes to Scottish chemist

WASHINGTON, April 29, 2010 The American Chemical Society Green Chemistry Institute (ACS GCI) Pharmaceutical Roundtable has awarded its 2010 research grant to Scottish chemist David Cole-Hamilton, Ph.D., for making great strides in expanding green chemistry and engineering practices in the global pharmaceutical industry. Cole-Hamilton will use the one-year $150,000-grant to further his study of the hydrogenation of amides to amines, resulting in improved benefits for the environment. He is the Irvine Professor of Chemistry, EaStCHEM, University of St. Andrews, Scotland.

Cole-Hamilton's research seeks to provide safer and environmentally friendly solutions to convert amides to amines, important in the development of many pharmaceutically active compounds. Conversion of the amide to the amine is usually conducted using a metallic hydride source such as sodium borohydride or lithium aluminum hydride.

The reactions are stoichiometric and large amounts of aluminum- or boron- containing side products are formed. Requiring separation from the desired amine product, these side products are usually disposed of in a landfill. The Roundtable identified greener amide reductions as one of the 12 key green chemistry research areas important for the pharmaceutical industry.

Cole-Hamilton's study will build upon exciting preliminary results, which proved it should be possible to use catalytic amide hydrogenation, which would only give water as a side product. If the catalyst is very active or can be recycled, there is no need for any significant waste from this reaction.

Since 2007 the grant program has awarded $800,000 toward research in the 12 key green chemistry research areas. All funding is made possible by a partnership between the ACS GCI and an alliance of major pharmaceutical companies Abbott Laboratories, AstraZeneca, Boehringer Ingelheim, Codexis, Dr. Reddy's, DSM Pharmaceutical Products, Eli Lilly and Company, GlaxoSmithKline, Johnson & Johnson, Merck & Co., Inc., Novartis, Pfizer, and Roche.

Under the leadership of Cole-Hamilton, the St. Andrews group will collaborate with members of the Roundtable to improve the technology and allow it to be introduced widely and without restriction into the pharmaceutical industry. Major targets will be lowering the temperature and especially the pressure at which reactions are carried out, improving the selectivity toward the desired amines (currently 85-90 percent, with alcohols as the side products) and exploring scope and the functional group tolerance of the reaction.


Contact: Julie Manley
American Chemical Society

Related biology news :

1. Study gives green light to plants’ role in global warming
2. Georgia Powers Green Energy Program Redesigned to Include More Solar Power
3. New York City Regional Extension Center Selects Greenway
4. New evidence that green tea may help fight glaucoma and other eye diseases
5. From bacteria to electricity: The future of green energy
6. Demystifying yield fluctuations for greenhouse tomatoes
7. Solid-state illuminator reduces nitrates in leafy green vegetables
8. Global study shows health joins green as business strategy
9. Early Earth absorbed more sunlight -- no extreme greenhouse needed to keep water wet
10. Spray application rate, equipment affect pest management in greenhouse ivy plants
11. More maize ethanol may boost greenhouse gas emissions
Post Your Comments:
Related Image:
ACS Green Chemistry Institute Pharmaceutical Roundtable award goes to Scottish chemist
(Date:10/29/2015)... Va. , Oct. 29, 2015 Daon, ... today that it has released a new version of ... customers in North America have ... IdentityX v4.0 also includes a FIDO UAF certified ... are already preparing to activate FIDO features. These customers ...
(Date:10/27/2015)... 27, 2015 In the present market scenario, ... for various industry verticals such as banking, healthcare, defense, ... growing demand for secure & simplified access control and ... as hacking of bank accounts, misuse of users, , ... as PC,s, laptops, and smartphones are expected to provide ...
(Date:10/26/2015)... -- Delta ID Inc., a company focused on bringing secure ... announced its ActiveIRIS® technology powers the iris recognition feature ... NTT DOCOMO, INC in Japan . ... include iris recognition technology, after a very successful introduction ... 2015, world,s first smartphone to have this capability. ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) ... chat discussion at the Piper Jaffray 27th Annual Healthcare ... discussion is scheduled for Wednesday, December 2, at 8:00 ... replay will be available for 14 days after the ... NormartVP, Corporate Communications and Business Development , BrewLife(858) 875-8629 ...
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association ... 2016 USGA Green Section Award. Presented annually since 1961, the USGA Green Section Award ... work with turfgrass. , Clarke, of Iselin, N.J., is an extension specialist ...
(Date:11/24/2015)... Mass. (PRWEB) , ... November 24, 2015 , ... ... to maintain healthy metabolism. But unless it is bound to proteins, copper is ... of Health (NIH), researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic ...
(Date:11/24/2015)... -- --> --> ... Market by Product & Services (Primer, Probe, Custom Oligos, ... End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) - Global ... expected to reach USD 1,918.6 Million by 2020 from ... 10.1% during the forecast period. Browse 183 ...
Breaking Biology Technology: