Navigation Links
ACRG and BGI report new evidence for the genetic bases of liver cancer
Date:7/1/2013

July 1, 2013, Shenzhen, China The Asian Cancer Research Group (ACRG), an independent, not-for-profit company in collaboration with BGI, the world's largest genomics organization, and The University of Hong Kong (HKU), jointly announced the publication of findings from a study of recurrent mutations in hepatocellular carcinoma (HCC), one of the most deadly cancers worldwide, in the international journal Genome Research. The study provides new insights into potential therapeutic intervention strategies for this common form of liver cancer.

HCC is a primary malignancy of the hepatocytes, generally leading to death within 6-20 months after diagnosis. This type of cancer is more common in parts of Africa and Asia, where the patients with hepatitis B or C are at risk for liver cancer, even if they have not developed cirrhosis. HCC has limited treatment options such as surgical resection of the tumor at its early stage, and the molecular basis of its occurrence and development remains poorly understood.

In this study, researchers used whole genome sequencing (WGS) to survey a cohort of 88 matched HCC tumor and normal samples from Hong Kong for investigating alerted genes and the pathways implicated in HBV-associated HCC. They found that TP53 was the most commonly mutated tumor suppressor gene, accounting for 35.2% in the HCC cohort. Generally, the patients with tumors containing TP53 mutations exhibited poor survival.

The Wnt/β-Catenin signaling pathway is central for liver functions and is frequently abnormal activated in the carcinogenesis of HCC. Researchers in this study found β-catenin maybe the most frequently mutated oncogene. In addition to β-catenin, they found relative high mutation rates in genes in the JAK/STAT pathway, which may act as a major oncogenic driver in HCC tumor progression.

Hancheng Zheng, group leader of this project at BGI, said, "Liver cancer is intractable to nearly all currently available anti-cance
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2

Related biology news :

1. APS issues new policy requiring identification of sex or gender in reporting scientific research
2. Report presents designs for study of cancer risks near US nuclear facilities
3. Researchers report potential for a moderate New England red tide in 2012
4. Aware, Inc. Reports First Quarter 2012 Financial Results
5. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
6. BGI reports the completed sequence of foxtail millet genome
7. Science reporters win ASM Public Communications Award
8. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
9. iView Systems iTrak® version 5.5 delivers optimized Incident Reporting
10. Report details efforts to improve, advance indoor microbial sampling
11. New report examines effects of trees killed by bark beetles on wildfire
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... larvae can swim up to 400 kilometres in search of ... environmental change. , Clownfish spend their entire adult lives under ... must wander the open ocean, says study co-author, Dr Hugo ... Studies (Coral CoE) at James Cook University. , "In the ... been given a rare glimpse into how far they can ...
(Date:9/17/2014)... Institute for the Arts and Humanities has received a ... a two-year project, "The Boundaries of the Human in ... will support a wide-ranging series of events aimed at ... One involves artists and researchers who are exploring the ... idea of humanism, and the other involves the increasingly ...
(Date:9/17/2014)... -- "Nature has developed, very cleverly, some lessons on ... optical design," said Joseph Shaw, director of the Optical ... surfaces and structures at the nanoscale, we,ll discover them." ... Diego in August during a conference called "The Nature ... Rongguang Liang of the University of Arizona College of ...
Breaking Biology News(10 mins):Nemo's epic journey to find a new home 2Mellon Foundation awards grant for major project in the humanities and sciences 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3
... by a team of researchers led by Jeffrey Peng, ... of Notre Dame, is using Nuclear Magnetic Resonance (NMR), ... dynamic flexibility of drugs and their targets. The ... American Chemical Society, contributes to the growing attention given ...
... Spanish . , Researchers at the Centre ... the Universidad de Kentucky (USA), have discovered a new way ... pathogen agents responsible for transmissible spongiform encephalopathies or TSEs) by ... control prion disease in deer, which has become an epidemic ...
... Swedish medical university Karolinska Institutet presents a new technique ... the first time. By examining people who had received ... that in all cases there were traces of amphetamine ... tests have been carried out using urine and blood ...
Cached Biology News:Nuclear magnetic resonance aids in drug design 2Researchers embark on work to control the prion epidemic affecting deer in the USA 2Researchers embark on work to control the prion epidemic affecting deer in the USA 3New technique enables drug tests via exhaled breath 2
(Date:9/18/2014)... -- Research and Markets has announced ... Report 2014" report to their offering. ... is a professional and in-depth study on the ... The report provides a basic overview of ... chain structure. The N-acetylcysteine market analysis is provided ...
(Date:9/18/2014)... -- U.S. biotech company Kultevat has strengthened its ... developed by the Donald Danforth Plant Science Center ... applications in production of natural rubber in Taraxicum ... under the direction of Roger Beachy , Ph.D., ... the Danforth Plant Science Center, and is used to ...
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 ... en 1974, a été depuis 40 ... les évaluations cliniques traditionnelles par des évaluations ... et sur les impacts économiques des traitements. ... A cours d,une récente ...
(Date:9/18/2014)... a group of rare diseases that afflict skeletal ... onset hits at the fetal stage and is ... gene encoding fibroblast growth factor receptor 3 (FGFR3) ... dysplasia, thanatophoric dysplasia (TD), a skeletal dysplasia that ... often lethal, and achondroplasia (ACH), which causes stunted ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 21974 - 2014 - Mapi fête ses 40 ans 2Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3
... , , SAO PAULO , Feb. ... to postpone a decision to reduce Brazil,s ,ethanol import duty from ... to be announced, but not for its impact to take effect once ... it describes as little more than a "bureaucratic" delay. , ...
... , SAN FRANCISCO , ... a leader in Integrated Voice Response (IVR)/Integrated Web Response (IWR) ... allows users to design and deploy clinical trial Integrated Response ... of clinical trials. This time and cost savings stems from ...
... ... nematodes as the Divergence and National Corn Growers Association continues collaboration. , ... (PRWEB) February 9, 2010 -- ... Research (SBIR) grants totaling $500,000, along with renewed funding from the National Corn Growers ...
Cached Biology Technology:Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 2Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 3endpoint Saves Money and Time for Medical Research Teams Through PULSE 2endpoint Saves Money and Time for Medical Research Teams Through PULSE 3New Funding Validates Importance of Divergence's Work on Nematodes 2New Funding Validates Importance of Divergence's Work on Nematodes 3