Navigation Links
ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
Date:5/29/2012

May 29, 2012, Shenzhen, China The Asian Cancer Research Group (ACRG)an independent, not-for-profit company established by Eli Lilly and Company, Merck (known as MSD outside the United States and Canada) and Pfizer Inc.in collaboration with BGIthe world's largest genomics organizationtoday announced the publication of results from a whole genome-wide study of recurrent hepatitis B virus (HBV) integration in hepatocellular carcinoma (HCC) in Nature Genetics. Results from this first-of-its-kind study provide important insights that may be used to improve diagnosis and treatment of HCC, the most common form of liver cancer worldwide.

"This study provided new insight into mechanisms of HBV integration, which promote liver cancer and affect clinical outcomes," said Dr. Ken Sung, lead author of the publication, National University of Singapore (NUS) and Honorary Associate Professor of Hong Kong University (HKU). "We expect further investigation may lead to improved diagnosis and treatment of HCC."

HBV integration is thought to be one of the major causes of HCC and research has shown that the DNA of HBV could integrate into a host genome in such a manner as to induce chromosomal instability (a defining characteristic of most human cancers) or alter expression and function of endogenous genes. Previous studies of HBV integration into the HCC genome have been limited by technological hurdles and relatively small sample sizes.

In this study, ACRG, BGI and other collaborators carried out whole-genome sequencing in a large sample cohort of Chinese patients with HCC to characterize genome integration patterns and determine the prevalence of integrated HBV. Through the sequencing and analysis, researchers found that HBV integration was a common event in liver tumors and was observed more frequently in tumors (86.4 percent) than in adjacent normal liver tissues (30.7 percent). In addition to the previously reported TERT and MLL4 genes, resear
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
2. Synaptics to Report First Quarter Results on October 23
3. GEN reports on novel tools for deciphering biological networks
4. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
5. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
6. Synaptics Reports Record Results for First Quarter of Fiscal 2009
7. Communication Intelligence Corporation Reports Third Quarter 2008 Financial Results
8. Orchid Cellmark Reports Third Quarter 2008 Financial Results
9. Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics
10. Marked improvement in body image, physical stamina, post-surgical pectus patients report
11. GEN reports growing focus on PI3-kinase pathway in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... release is available in German . ... a method that uses the refraction of X-rays through ... images produced with this method are often of much ... in the team of Prof. Franz Pfeiffer are particularly ... and therapy including X-ray phase-contrast imaging. One main ...
(Date:7/11/2014)... 3, 2014, Shenzhen, China Researchers from Salk Institute ... the first time evaluated the safety and reliability ... successfully developed a new method, TALEN-HDAdV, which could ... stem cell (hiPSC). This study published online in ... theoretical foundation for stem cell-based gene therapy. , ...
(Date:7/11/2014)... 11, 2014 Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... first comprehensive multi-model-based assessment of so-called Durban Platform scenarios, ... the Potsdam Institute for Climate Impact Research (PIK) and ... Durban Platform is the current negotiation track at the ... climate agreement by 2015 to come into effect in ...
... developing a comprehensive data system that can be used ... them with access to chemical toxicity information. ... the "automated profiling system" from existing bioassay data from ... help scientists who are seeking information on chemicals of ...
... continues to support the role of protein in building and ... embracing the important role of protein in the diet. ... out that protein quality really does matter. The latest ... at SupplySide West, the leading destination for the exploration, discovery, ...
Cached Biology News:Success of climate talks vital for 2°C target 2Success of climate talks vital for 2°C target 3Toxicity database under development at Rutgers-Camden 2Protein quality: It matters 2Protein quality: It matters 3
(Date:7/11/2014)... , July 11, 2014 /CNW/ - Sunovion Pharmaceuticals Canada ... TM (eslicarbazepine acetate) for use as a once-daily ... patients with epilepsy who are not satisfactorily controlled with ... use in patients under 18 years of age. ... neurological disorders and according to Epilepsy Canada, it affects ...
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... Age of Unreason," an important book in which author ... business-affecting change. Though an economist, Handy could not have ... our current recession, yet he offers a prescient perspective ... a shift from manufacturing- to a knowledge-based economy. , ...
... challenging, but knowing how to conduct the proper interviews can ... getting the right person. If its a top executive position ... of the candidates background is critical, but having a method ... experiences increases the chances of hiring the right person. ...
... Catalyst International, a global provider of supply ... of platform-independent SCE applications. , ,"We're expanding and ... increasing demand for integrated fulfillment solutions from supplier ... said Jim Treleaven, President and CEO of Catalyst. ...
Cached Biology Technology:The Molecular Organization 2The Molecular Organization 3Improving the Hiring Process 2
... immunowash microplate washer 100-240 V, is used ... U-, or V-bottom wells. The immunowash microplate ... needle positions to an accuracy of 0.1 ... overflow washing. It can store up to ...
... compact benchtop and stackable multi-function incubator. ... a large display screen to accurately ... circulation inside to evenly distribute temperature ... easily calibrated from the microprocessor controller. ...
... RM is specifically designed as a high ... new variable mass compensation allows high shaking ... better aeration and, therefore, faster growth and ... is ideal when high reproducibility is critical ...
...
Biology Products: