Navigation Links
ACMG releases report on incidental findings in clinical exome and genome sequencing
Date:3/21/2013

The American College of Medical Genetics and Genomics (ACMG) released the widely-anticipated "ACMG Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing" report at its 2013 Annual Clinical Genetics Meeting today in Phoenix. The ACMG Annual Clinical Genetics Meeting is one of the largest gatherings of medical and health professionals in genetics in the world.

As exome and genome sequencing become more commonly used in medical care, doctors will increasingly be able to learn about genetic changes that increase an individual's risk for developing an unrelated disease. In the past, these incidental genetic findings (unrelated to the condition for which the patient was tested) were seldom provided to the patient.

The ACMG has now created a set of recommendations addressing incidental findings and a minimum list of conditions, genes, and variants that are recommended to be returned whenever clinical sequencing is performed. The ACMG now recommends that for the conditions on the list, the laboratory should return the incidental findings to the doctor ordering the sequencing, and those doctors should manage this information with the patient in the context of that patient's clinical presentation and family history.

Incidental, or secondary, findings, are health-related interpretations of a patient's genetic code that are unrelated to the primary reason for ordering the testing. For example, if an exome or genome sequence were ordered to help diagnose a cardiac condition, there would exist the possibility of finding a different gene that indicated a predisposition for cancer. If the cancer risk were reported to the ordering clinician as an incidental finding, the clinician and patient could explore whether to increase medical surveillance in a way that could catch a cancer earlier and reduce mortality in that patient.

The extensive 27-page report was developed through a year-long consensus p
'/>"/>

Contact: Kathy Ridgely Beal
kbeal@acmg.net
301-238-4582
American College of Medical Genetics
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. American Academy of Microbiology releases resistance report
2. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
3. Medbox, Inc. Releases Demo Video and Collateral Media Concerning How Their Systems Will Be Used in Massachusetts Medical Marijuana Dispensaries
4. Wildlife Conservation Society releases list of Asian species at the conservation crossroads
5. American Meteorological Society releases revised climate change statement
6. Medbox, Inc. Releases 2nd Quarter Financials
7. University of Tennessee professor releases weight management product
8. NSF releases report detailing nationwide and state-by-state R&D activities
9. SF State researcher releases first results from nationwide bee count
10. AAO-HNS releases updated Clinical Indicators
11. Spanish researcher releases a video showing a beetle from the inside
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... day, insects provide the white noise of the South, but ... year, the Southern air hangs heavy from the humidity and ... more than 140 species of frogs, toads and salamanders, is ... the ponds and swamps are the auditorium for their symphonic ... and Monitoring Initiative, or ARMI, have front-row seats. ...
(Date:5/17/2013)... proteins in the brain responsible for protecting nerve cells ... increase cell survival. , The discovery, made by researchers ... the EMBO journal with additional comment in ... stroke and other brain diseases. , The research builds ... protein, known as SUMO, responsible for controlling the chemical ...
(Date:5/17/2013)... A new Dartmouth College study finds human-caused climate ... of tropical lizards, contradicting a host of recent ... rapidly warming planet. , The findings, which appear ... offer new hope for survival of a creature ... Most predictions that tropical cold-blooded animals, especially forest ...
Breaking Biology News(10 mins):Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4SUMO wrestling cells reveal new protective mechanism target for stroke 2Climate change may have little impact on tropical lizards 2
... . Most of the functions performed by a ... their binding partner by affinity features localized on the protein ... complicated to study from the perspective of structural biology are ... and occurs through a large section of the protein surface- ...
... More evidence for the beneficial effect of green tea ... a new study reported in the latest issue of ... The study found that the consumption of green tea ... circulatory system; endothelial dysfunction is a key event in ...
... the July/August 2008 issue of BioScience are as ... Bonneaud, Joan Burnside, and Scott V. Edwards. , An increasingly ... thus expanding what has been learned from studies based on ... evolution of the whole class. ***************, Penguins as ...
Cached Biology News:Scientists reveal the key mechanisms for affinity between transient binding proteins 2The benefits of green tea in reducing an important risk factor for heart disease 2BioScience tip sheet July/August 2008 2BioScience tip sheet July/August 2008 3
(Date:5/16/2013)... 16, 2013 ISPE ... Myers, CAE, to the newly created position of ... role, Myers will be responsible for stimulating ISPE’s ... strategies, advancing the Society’s Member-led and staff-driven business ... to refine organizational, membership and product marketing. , ...
(Date:5/16/2013)... 2013 Cambridge Healthtech Institute will host ... 2013 at the Renaissance Waterfront Hotel in Boston, MA. ... close-up look at the current strategies and innovations for ... Leaders in the field will reveal how their ... with greater specificity and efficiency. , “In this age ...
(Date:5/16/2013)... May 16, 2013 Scientists at the Center ... , and the California -based ... a novel therapy for reversing memory decline in mice ... find significant cognitive improvement in advanced stage AD mice. ... for reversing cognitive decline for advanced stage AD mice, ...
(Date:5/16/2013)... , May 16, 2013 ... research report is available in its ... Cardiac Biomarkers for Acute Coronary Syndromes ... http://www.reportlinker.com/p01182969/MediPoint-Diagnostic-Cardiac-Biomarkers-for-Acute-Coronary-Syndromes---APAC-Analysis-and-Market-Forecasts.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... Acute Coronary Syndromes - APAC Analysis ...
Breaking Biology Technology:ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 2MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 3MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 4MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 5MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 6MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 7MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 8
... Forest Laboratories, Inc.,(NYSE: FRX ) and H. ... Court,of Appeals for the Federal Circuit has affirmed a ... the District of Delaware which determined that,the U.S. patent ... upheld the injunction preventing Ivax/Teva,s proposed generic,product launch, thereby ...
... a Proven Leader at Driving Growth, SAN FRANCISCO, ... equity firm that focuses on investments in selected segments,of ... software, today announced the appointment of Michael L. Hurt,to ... Mr. Hurt, CEO,of Altra Industrial Motion (Nasdaq: AIMC ...
... Diagnostic Systems Installs CTLM(R) in Tianjin, China, ... Inc., (OTC Bulletin Board: IMDS) a pioneer in ... CT Laser Mammography,(CTLM(R)) system at the Tianjin Medical ... center in China. (Logo: http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ...
Cached Biology Technology:Forest Laboratories Announces Federal Appeals Court Upholds Lexapro(R) Patent Decision 2Genstar Names Michael Hurt to Its Strategic Advisory Board 2Largest Asian Cancer Hospital to Evaluate New CT Laser Breast Imaging System 2Largest Asian Cancer Hospital to Evaluate New CT Laser Breast Imaging System 3
... AcTEV Protease is an enhanced form ... is highly site-specific, highly active, and significantly ... in long-term activity. AcTEV Protease specifically recognizes ... Gln and Gly), making it useful for ...
versican (H-56)...
Vapor phase risers are available in various heights to accomodate a variety of inventory solutions. Risers are used to creat a false bottom in which the tanks platform rests and Liquid nitrogen is s...
... Anti-M13 Anti-M13 polyclonal antibody was derived ... bacterial phage particles.Recombinant protein domains such as ... coat protein pIII and displayed on phage ... phage-based system utilized in the Ph.D. libraries. ...
Biology Products: