Prior to the new research, this part of the knee was "poorly understood," said Dr. LaPrade. "Clinical diagnostic exams were mainly subjective, imaging techniques were not defined, and most surgical reconstruction procedures were not anatomically based or validated. Treatment frequently resulted in recurrent instability and failures," and while posterolateral knee injuries often coincided with cruciate ligament damage, the PLC injuries often were overlooked.
"Proper treatment of grade 3 PLC injuries requires a comprehensive understanding of the anatomy and clinically relevant biomechanics to synthesize the various clinical exams utilized to to diagnose these injuries," said Dr. LaPrade. "The results of our studies have greatly improved the understanding and treatment of what used to be called, 'the dark side of the knee.'"
Control of Bone Healing by Mechanical Factors
Elise Feng-I Morgan, PhD, an associate professor of mechanical engineering, orthopaedic surgery and biomedical engineering at Boston University, received the Kappa Delta Young Investigator Award for her findings on the role of mechanical cues in bone healing.
Dr. Morgan and her team discovered that different manipulations, such as tension versus bending, produced markedly different microenvironments at the site of bone injury. These microenvironments may be linked to the differences in healing that are observed with the different manipulations, and also may be related to differences in gene expression.
These findings indicate the potential for identifying casual links between the mechanics of a skeletal defect and the repair response, as well as the role of imaging and mechanical testing in determining the microenvironment in the bone injury, and consequences for healing. The research may lead to the identification of new molecular targets for enhancing repair.
|Contact: Lauren Pearson Riley|
American Academy of Orthopaedic Surgeons