Navigation Links
AAOS awards recognize innovative orthopaedic research
Date:3/19/2013

CHICAGO The Kappa Delta Sorority and the Orthopaedic Research and Education Foundation (OREF) presented four research awards to scientists who are helping to close the gap between basic research and patient treatment and care. Honored at the 2013 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS), these award winners have made recent discoveries in the following areas of musculoskeletal health:

  • Bio-enhanced ACL repair
  • The diagnosis and treatment of posterolateral (outside and back) corner knee injury
  • Skeletal muscle design and the implications for orthopaedic surgery
  • The role of mechanical factors in bone healing

The Biology of ACL Injury and Repair

The 2013 Kappa Delta Ann Doner Vaughn Award was presented to Martha M. Murray, MD, of Boston Children's Hospital, for the study, "The Biology of ACL Injury and Repair."

The paper outlines 25 years of research and discovery leading to the novel development of a "bio-enhanced" ACL repair procedure that "stimulates healing and regeneration of the ACL" and minimizes future injury-related osteoarthritis in preclinical models, said Dr. Murray.

First, Dr. Murray's team determined that the premature loss of the provisional scaffold (scar tissue) surrounding the ACL prevents healing. That discovery led them to develop and test various methods to stimulate the healing of these tissues within the ACL wound site. Most promising was the creation and successful implant of a substitute, provisional scaffold that restored functional healing in animal tests. The procedure is far less invasive than current ACL repair surgery.

"This less invasive method has shown promise in preclinical models, where the strength of the repaired ACL is similar to that of an ACL reconstruction at 3 months, 6 months and 1 year," said Dr. Murray. "In addition, the premature osteoarthritis seen in the reconstructed knees was not seen in the knees treated with bio-enhanced repair."

Design of Human Skeletal Muscles: Implications for Orthopaedic Surgery

Richard L. Lieber, PhD, of the University of California, San Diego, received the 2013 Kappa Delta Elizabeth Winston Lanier Award for his research outlining the complex and varying characteristics of skeletal muscles, and the implications of these differences in orthopaedic surgery and patient outcomes.

"Skeletal muscles demonstrate a sophisticated design at a variety of levels," said Lieber. For example, the wrist is "composed of muscles with varying fiber length and fiber which makes some of them very strong, while others can move greater distances."

Lieber and his team developed a portable tool that passes laser light through muscles during surgery, recording a pattern that precisely measures the sarcomere, the microscopic machinery of the muscle. In addition, the researchers documented the unprecedented changes that occur in muscle contractures.

"This tool and concept allows surgeons to move muscles, and to objectively set them to the length at which they will develop the maximum force instead of simply relying on the feel of muscle in the operating room," said Lieber.

When doing a tendon transplant or transfer, "this information can be used to determine the best donors to restore lost function due to injury."

Improving Outcomes for Posterolateral Knee Injuries

Robert LaPrade, MD, PhD, a complex knee surgeon at the Steadman Clinic in Vail, Colo., was awarded the 2013 Orthopaedic Research and Education Foundation (OREF) Clinical Research Award for his work on improving diagnosis and treatment for complex injuries to the posterolateral (back corner) of the knee.

Based on an extensive number of peer reviewed publications on this topic, Dr. LaPrade and his research team developed a set of guidelines and anatomic-based surgical reconstructions that clinicians can use to diagnosis and treat injuries to the posterolateral corner (PLC) of the knee.

Prior to the new research, this part of the knee was "poorly understood," said Dr. LaPrade. "Clinical diagnostic exams were mainly subjective, imaging techniques were not defined, and most surgical reconstruction procedures were not anatomically based or validated. Treatment frequently resulted in recurrent instability and failures," and while posterolateral knee injuries often coincided with cruciate ligament damage, the PLC injuries often were overlooked.

"Proper treatment of grade 3 PLC injuries requires a comprehensive understanding of the anatomy and clinically relevant biomechanics to synthesize the various clinical exams utilized to to diagnose these injuries," said Dr. LaPrade. "The results of our studies have greatly improved the understanding and treatment of what used to be called, 'the dark side of the knee.'"

Control of Bone Healing by Mechanical Factors

Elise Feng-I Morgan, PhD, an associate professor of mechanical engineering, orthopaedic surgery and biomedical engineering at Boston University, received the Kappa Delta Young Investigator Award for her findings on the role of mechanical cues in bone healing.

Dr. Morgan and her team discovered that different manipulations, such as tension versus bending, produced markedly different microenvironments at the site of bone injury. These microenvironments may be linked to the differences in healing that are observed with the different manipulations, and also may be related to differences in gene expression.

These findings indicate the potential for identifying casual links between the mechanics of a skeletal defect and the repair response, as well as the role of imaging and mechanical testing in determining the microenvironment in the bone injury, and consequences for healing. The research may lead to the identification of new molecular targets for enhancing repair.

"Many approaches to studying ways to improve bone healing focus on biological factors: proteins, genes, and cells," said Morgan. "Our research does overlap with these approaches, but we also examine the role of mechanical forces and deformations that the healing tissues experience. These mechanical factors are incredibly potent in affecting healing. Understanding these factors can help in identifying more effective means of treating bone injuries. Also, study of bone healing is a fertile area for determining the capacity of our bodies to regenerate tissues. The ability to control the mechanical cues that cells and tissues experience will be a key part of the future of musculoskeletal tissue regeneration."


'/>"/>

Contact: Lauren Pearson Riley
pearson@aaos.org
708-227-1773
American Academy of Orthopaedic Surgeons
Source:Eurekalert

Related biology news :

1. March of Dimes awards $250,000 to researcher who identified heart disease genes
2. MARC Travel Awards announced for Immunohistochemistry and Microscopy (IHCM) Short Course 2013
3. FASEB MARC Travel Awards announced for the 2013 American College of Sports Medicine Northwest Chapter Meeting
4. NIH awards nearly $2 million to 3 NYC institutions for chronic fatigue syndrome research
5. Winners of the 2012 F1000Prime Faculty Member of the Year Awards
6. Elsevier wins 6 PROSE Awards
7. Virginia Tech adjunct and colleagues refute a study on racial bias report in NIH awards
8. Jackson Laboratory professor emeritus Douglas Coleman wins BBVA, King Faisal awards
9. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
10. Biophysical Society announces winners of 2013 international travel awards
11. Biophysical Society announces winners of 2013 Education Committee travel awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... ... ... Supplyframe, the Industry Network for electronics hardware design and ... in Pasadena, Calif., the Design Lab’s mission is to bring together inventors and ... brought to market. , The Design Lab is Supplyframe’s physical representation of one ...
Breaking Biology Technology: