Navigation Links
AACR news: New target plus new drug equals death of melanoma cells
Date:4/9/2013

Collaborative research presented by the University of Colorado Cancer Center, the University of North Carolina at Chapel Hill, Harvard Medical School and the University of Pittsburgh, at the American Association for Cancer Research (AACR) Annual Conference, shows that the protein receptor Mer is overexpressed in melanoma and that the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them.

"It's exciting in that Mer receptor expression correlates so perfectly with disease progression. It's tiered you see a bump in expression as you transition from nevus to melanoma and then again as you transition from melanoma to metastatic disease," says Doug Graham, MD, PhD, investigator at the CU Cancer Center and associate professor of Pediatrics and Immunology at the University of Colorado School of Medicine, the paper's senior author.

After proving this correlation between Mer receptor expression and disease stage in melanoma tissues from clinical patient samples, Graham and colleagues wondered what would happen if they interrupted this Mer signaling. Luckily, the University of North Carolina had recently developed a new compound that did just that UNC1062. The results were dramatic.

"We showed decreased survival signaling, increased apoptosis and decreased growth of the melanoma cells in dishes and in mouse models," Graham says. It seems that Mer receptors are not only correlated with melanoma progression but are in fact driving the aggressiveness of the disease.

"This is the first time there's been an association between Mer and melanoma and the first time to report about this new drug," Graham says.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Page: 1

Related biology news :

1. Good news: Fewer maternal and child deaths
2. REACH news: European ombudsman takes up PETA complaint
3. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
4. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
5. AACR news: Little molecule makes big difference in bladder cancer metastasis
6. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
7. Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
8. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
9. Nanobubbles plus chemotherapy equals single-cell cancer targeting
10. Researchers identify Achilles heel of dengue virus, target for future vaccines
11. Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... as the prolific bloomer Emiliania huxleyi , can ... The finding contradicts the common view that E. ... scarce supplies of thiamine in the ocean to survive. ... the ocean," says CIFAR Senior Fellow Alexandra Worden ... with CIFAR fellows John Archibald (Dalhousie University), ...
(Date:8/29/2014)... them, fold them: modern materials that are light, flexible ... artificial skin or electronic paper. , Making such concepts ... a new way of working with copper nanowires and ... , Previous success in the field of ultra-lightweight "aerogel ... gold and silver nanowires. , By turning instead ...
(Date:8/28/2014)... app called TX Invasives is now available from the ... Texas at Austin for identifying harmful non-native plant, insect ... in the United States cause about $137 billion in ... crops, clog waterways, kill native plants and more. , ... for reporting where invasive species occur, we,re more likely ...
Breaking Biology News(10 mins):Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Copper shines as flexible conductor 2Mobile app makes ID of harmful plants, insects in Texas a snap 2
... Spanish . , A new beetle that could be ... identified by Agricultural Research Service (ARS) scientists and cooperators. ... Thailand by entomologists Bob Pemberton (now retired), with the ARS ... Wright, with the ARS Australian Biological Control Laboratory (ABCL) in ...
... Presenting at the UK National Stem Cell Network ... a new approach to treating heart attack and cardiomyopathy ... Professor at Imperial College London, said "Recent clinical trials ... successful in terms of safety but unfortunately the bone ...
... State,s College of Agricultural Sciences will lead a seven-year, ... Liwang Cui, professor of entomology, is the principal investigator ... 10 International Centers of Excellence for Malaria Research announced ... part of the National Institutes of Health. About 40 ...
Cached Biology News:Scientists identify new potential biocontrol for skunk vine 2Improving clinical use of stem cells to repair heart damage 2Penn State to lead new international Center Of Excellence for malaria research 2Penn State to lead new international Center Of Excellence for malaria research 3
(Date:8/29/2014)... VANCOUVER , Aug. 29, 2014 /PRNewswire/ - ... (OTCQX: ICOTF), today reported financial results for the ... specified otherwise, are expressed in Canadian dollars and ... Second Quarter 2014 Highlights , ... visual acuity (VA) primary endpoint for subjects enrolled ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 ... ones in the biotech start-up dense realm of Boston-Cambridge, ... alliances and able investors. James Sherley, the Director of ... made increasing the local and national visibility of his ... in September 2013. , In addition to a social ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... First to be Awarded Shingo Prize Outside of North ... ... International Inc.,s,(NYSE: BAX ) manufacturing facility in Cartago, Costa Rica has ... first to be awarded the Shingo Prize outside North America,-- is being ...
... with Cardiovascular and Digestive Disease ... ... Medical University,of South Carolina (MUSC) opens the doors of Ashley River ... digestive disease problems. Ashley River Tower marks the first step in,the ...
... 4 A recent study published this month,in the ... powder,and shampoo is linked to the presence of phthalates ... in a wide variety of everyday,products. They are used ... and can also be used to stabilize and make,fragrances ...
Cached Biology Technology:Baxter's Costa Rica Facility Recognized With Shingo Prize for Excellence in Manufacturing 2Medical University of South Carolina Opens State-of-the-Art Facility 2Medical University of South Carolina Opens State-of-the-Art Facility 3Medical University of South Carolina Opens State-of-the-Art Facility 4Statement by John Bailey, Chief Scientist: The Personal Care Products Council Response to Study on Phthalate Exposure in Baby Care Products 2
Anti-LC3 Polyclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
...
... biological cells for DNA isolation. ... plates (includes 96 well plate adapters ... across the entire plate length (max ... Can be used for soil, microorganisms, ...
... Chicken polyclonal to LYZL6 ( ... Antigen: Synthetic ... DYKSYSENLC HVDCQD , corresponding to amino ... Entrez Gene ID: ...
Biology Products: