Navigation Links
AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
Date:4/9/2013

Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. Results presented at the AACR Annual Meeting 2013 show that in lung and bladder cancers, genes related to the regulation of the cell cycle are associated with poor patient outcomes.

"We ultimately envision this as a prognostic tool to predict survival rates for people with tobacco related cancers. Recognizing patients with high expression of these genes could help us predict risk and so match patients with the most appropriate treatments," says Garrett Dancik, PhD, postdoc in the lab of Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center.

The study mined data from publicly-available tumor registries that included a total of 1996 samples of cancer types including lung adenocarcinoma, squamous cell lung carcinoma, bladder transitional cell carcinoma, and head and neck squamous cell carcinoma. The question was this: what common genetic signatures would correlate with patient outcomes? Interestingly, researchers had previously asked this question of prostate cancer and had developed a panel of 31 cell-cycle related genes that predict the aggressiveness of the disease. Once Dancik and Theodorescu narrowed in on pathways controlling cell cycle as possibly predictive in tobacco-related cancers, they wondered if the same 31-gene panel might work with these cancers as well.

"Take out the squamous cell cancers and the panel is strongly predictive of patient outcomes," Dancik says. "This is a strong tool that could have a really useful application only it seems there's something unique going on with the squamous cell types of tobacco-associated cancers that's not true for the others."

In Dancik's opinion, the discovery of correlation between cell cycle gene signatures and patient outcomes is an important first step in developing new ways to predict the risks of tobacco-associated cancers. The work now is in integrating this finding with existing risk assessments.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Related biology news :

1. Good news: Fewer maternal and child deaths
2. REACH news: European ombudsman takes up PETA complaint
3. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
4. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
5. AACR news: Little molecule makes big difference in bladder cancer metastasis
6. AACR news: New target plus new drug equals death of melanoma cells
7. AACR news: K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer
8. Fruit fly studies guide investigators to misregulated mechanism in human cancers
9. Planarian genes that control stem cell biology identified
10. Culprit behind unchecked angiogenesis identified
11. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)...  For the thousands of attendees at this year,s International Consumer Electronics ... and biometric measurement devices and services, will be featuring its new line ... A&D Medical,s special CES Exhibit Suite , the new upper arm ... company,s WellnessConnected product platform.  ... ...
(Date:1/3/2017)... LAS VEGAS , Jan. 3, 2017 ... announced the introduction of Onitor Track, an innovative biometric ... and men, showcasing this month at the 2017 Consumer ... . In the U.S., the World ... affect more than two-thirds of adults who are overweight ...
(Date:12/22/2016)... YORK , December 22, 2016 ... provider of secure solutions for the e-Government, Public Safety, HealthCare, and ... subsidiary of SuperCom, has been selected to implement and deploy a ... in Northern California , further expanding its presence ... ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... , Jan. 12, 2017   Protein ... and maker of Flublok Influenza Vaccine ®, ... vaccine candidate had good safety results and induced ... preclinical studies. The product is expected to advance ... months.  In addition, the Institute of Technology in ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... has enhanced the platform to accommodate increasingly complex and sophisticated deployments, resulting ... and more. In addition to these improvements, the latest release brings enhanced ...
(Date:1/11/2017)... ... January 11, 2017 , ... As a graduate student, ... the pathogens that cause malaria and tuberculosis. Seeing firsthand the ravages those diseases ... Now, as an assistant professor of biology and biotechnology at Worcester Polytechnic Institute ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... year and costing healthcare systems more than $23.7 billion, healthcare systems are ... , Among the most common sepsis-causing pathogens are bacteria and the yeast ...
Breaking Biology Technology: