Navigation Links
AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
Date:4/9/2013

Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. Results presented at the AACR Annual Meeting 2013 show that in lung and bladder cancers, genes related to the regulation of the cell cycle are associated with poor patient outcomes.

"We ultimately envision this as a prognostic tool to predict survival rates for people with tobacco related cancers. Recognizing patients with high expression of these genes could help us predict risk and so match patients with the most appropriate treatments," says Garrett Dancik, PhD, postdoc in the lab of Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center.

The study mined data from publicly-available tumor registries that included a total of 1996 samples of cancer types including lung adenocarcinoma, squamous cell lung carcinoma, bladder transitional cell carcinoma, and head and neck squamous cell carcinoma. The question was this: what common genetic signatures would correlate with patient outcomes? Interestingly, researchers had previously asked this question of prostate cancer and had developed a panel of 31 cell-cycle related genes that predict the aggressiveness of the disease. Once Dancik and Theodorescu narrowed in on pathways controlling cell cycle as possibly predictive in tobacco-related cancers, they wondered if the same 31-gene panel might work with these cancers as well.

"Take out the squamous cell cancers and the panel is strongly predictive of patient outcomes," Dancik says. "This is a strong tool that could have a really useful application only it seems there's something unique going on with the squamous cell types of tobacco-associated cancers that's not true for the others."

In Dancik's opinion, the discovery of correlation between cell cycle gene signatures and patient outco
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Good news: Fewer maternal and child deaths
2. REACH news: European ombudsman takes up PETA complaint
3. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
4. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
5. AACR news: Little molecule makes big difference in bladder cancer metastasis
6. AACR news: New target plus new drug equals death of melanoma cells
7. AACR news: K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer
8. Fruit fly studies guide investigators to misregulated mechanism in human cancers
9. Planarian genes that control stem cell biology identified
10. Culprit behind unchecked angiogenesis identified
11. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... the University of Kentucky has discovered new methods to ... , The research, led by Peixuan Guo, professor and ... UK College of Pharmacy and Markey Cancer Center, is ... Anionic Polymer Material To Build Robust Structures with Defined ... Daniel L. Jasinski. , The article, which will appear ...
(Date:4/22/2014)... a trip to Asia to coordinate with allies ... officials at the Office of Naval Research (ONR) ... (APTEP) as an example of strong and growing ... in the region. , The APTEP program, centered ... supports the development of alternative energy technologies. It ...
(Date:4/22/2014)... is another way of asking him or her to ... Certain cells of the immune system tend to misbehave ... Because these cells are known to misbehave similarly during ... immune cells to better understand how our immune systems ... Institute on Aging, part of the National Institutes of ...
Breaking Biology News(10 mins):RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2Full power: Alternative energy partnerships flourish in Asia 2Full power: Alternative energy partnerships flourish in Asia 3For an immune cell, microgravity mimics aging 2For an immune cell, microgravity mimics aging 3For an immune cell, microgravity mimics aging 4For an immune cell, microgravity mimics aging 5
... who must stay awake for long shifts ?soldiers, pilots, ... from new research showing that preventing the gas nitric ... off the sleep urge. , The research, conducted by ... Helsinki (Helsinki, Finland), ties together previous observations about sleep ...
... scientists have engineered yeast cells capable of producing ... fully human sugar structures (glycosylation). These sugar structures ... to date, have necessitated the expression of therapeutic ... has the potential to eliminate the need for ...
... Emory University's Winship Cancer Institute have identified a novel ... role the marker may play when the tumor spreads ... is elevated in the cerebrospinal fluid of patients with ... in the November issue of Clinical Cancer Research. ...
Cached Biology News:Need to pull an all-nighter? 2GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science 2Newly identified biomarker detects and regulates spread of brain tumors 2
(Date:1/15/2014)... Calif. (PRWEB) January 15, 2014 Cynvenio, ... and management through the genomic analysis of tumor cells ... Therapy Finder™, a web-based cancer decision support application powered ... option with Cynvenio’s ClearID™ genomic test, Therapy Finder will ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to announce ... organizations who need document translations. Clients will now have ... in advance with a selection of nearly 50 life science ... critical factor in clinical and scientific fields, and decrease the ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Small Tree Communications , a supplier of high-performance networking ... software protocol called Blaze, expected to ship in the third ... High-Definition digital video editing. , ,Blaze will make it ... on the newer high-end 10 gigabit Ethernet cards. It ...
... Corporation and Middleton-based Bone Care International Inc. announced ... their proposed merger. , ,Genzyme and Bone Care have signed ... Care in an all-cash transaction valued at $33.00 per ... by Bone Care's shareholders at a meeting on ...
... - Stratatech Corp. was awarded a federal ... of General Medical Sciences to further develop its engineered human ... Madison and employs 18 people, according to the 2005 edition ... Its products are based on a source of pathogen-free human ...
Cached Biology Technology:Small Tree is streamlining digital video editing 2Small Tree is streamlining digital video editing 3
2,4-Dinitrophenyl hapten is conjugated to Human Serum Albumin (HSA) protein through lysine....
PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry....
PGD2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry....
Request Info...
Biology Products: