Navigation Links
AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool

Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. Results presented at the AACR Annual Meeting 2013 show that in lung and bladder cancers, genes related to the regulation of the cell cycle are associated with poor patient outcomes.

"We ultimately envision this as a prognostic tool to predict survival rates for people with tobacco related cancers. Recognizing patients with high expression of these genes could help us predict risk and so match patients with the most appropriate treatments," says Garrett Dancik, PhD, postdoc in the lab of Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center.

The study mined data from publicly-available tumor registries that included a total of 1996 samples of cancer types including lung adenocarcinoma, squamous cell lung carcinoma, bladder transitional cell carcinoma, and head and neck squamous cell carcinoma. The question was this: what common genetic signatures would correlate with patient outcomes? Interestingly, researchers had previously asked this question of prostate cancer and had developed a panel of 31 cell-cycle related genes that predict the aggressiveness of the disease. Once Dancik and Theodorescu narrowed in on pathways controlling cell cycle as possibly predictive in tobacco-related cancers, they wondered if the same 31-gene panel might work with these cancers as well.

"Take out the squamous cell cancers and the panel is strongly predictive of patient outcomes," Dancik says. "This is a strong tool that could have a really useful application only it seems there's something unique going on with the squamous cell types of tobacco-associated cancers that's not true for the others."

In Dancik's opinion, the discovery of correlation between cell cycle gene signatures and patient outcomes is an important first step in developing new ways to predict the risks of tobacco-associated cancers. The work now is in integrating this finding with existing risk assessments.


Contact: Garth Sundem
University of Colorado Denver

Related biology news :

1. Good news: Fewer maternal and child deaths
2. REACH news: European ombudsman takes up PETA complaint
3. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
4. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
5. AACR news: Little molecule makes big difference in bladder cancer metastasis
6. AACR news: New target plus new drug equals death of melanoma cells
7. AACR news: K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer
8. Fruit fly studies guide investigators to misregulated mechanism in human cancers
9. Planarian genes that control stem cell biology identified
10. Culprit behind unchecked angiogenesis identified
11. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
Post Your Comments:
(Date:9/30/2015)... , Sept. 30, 2015  The U.S. Court ... issued another key ruling in favor of Crossmatch ... Korean fingerprint scanner company Suprema and its U.S. partner ... 1930, a trade provision that declares it unlawful to ... by infringing two of Crossmatch,s patents, the 5,900,993 patent ...
(Date:9/28/2015)... YORK , Sept. 28, 2015 /PRNewswire/ ... announced today that its expedited traveler service ... innovative platform transforms travel, bringing a frictionless ... its members. "CLEAR offers our ... enhances customer service," said Jim Smith ...
(Date:9/28/2015)... , Sept. 28, 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced that Lenovo has selected Synaptics , ... FS4202, for its latest smartphone, the Vibe P1. The ... to unlock the device and provide swift access to ... The feature-rich Natural ID FS4202 sensor solution utilizes AES256-bit ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... JACKSONVILLE, Florida , October 13, 2015 ... company specializing in the development of innovative peptide and ... & metastatic disease, will be a featured presenting company ... at the Wyndham Grand Hotel in ... --> TapImmune, Inc. (TPIV), a clinical-stage immunotherapy ...
(Date:10/13/2015)... ... October 13, 2015 , ... Clinovo recently appointed Jeff Parr ... company’s fast growing clinical data solutions business. , Jeff Parr has spent the past ... sizes, including Avery Dennison, Thermo Fisher, and Ab Sciex to name a few. ...
(Date:10/13/2015)... the United States , Canada ... of all new cases of kidney cancer.   --> ... and Europe .  PRCC represents about 14% of ... China MediTech Limited ("Chi-Med") (AIM: HCM) today announces that Hutchison MediPharma ... have completed enrolment in a global Phase II study of savolitinib ...
(Date:10/12/2015)... , Oct. 12, 2015 This report ... which include cell type, products, applications, end-user markets and ... REPORT HIGHLIGHTS The global cell expansion market generated ... expected to reach revenues of $9.7 billion in 2015 ... growth rate (CAGR) of 17.8% from 2015 to 2020. ...
Breaking Biology Technology: