Navigation Links
AACR news: Little molecule makes big difference in bladder cancer metastasis
Date:4/9/2013

In order to kill, bladder cancer must metastasize, most commonly to the lung what are the differences between bladder cancers that do and do not make this deadly transition? Research presented by the Director of the University of Colorado Cancer Center at the AACR Annual Meeting 2013 shows that one big difference is a little molecule known as hsa-miR-146a.

Messenger RNA or mRNA carries gene blueprints to sites where the plans are read and made into proteins, and to a large degree microRNA or miRNA tells mRNA what to do. Theodorescu's work shows that in 256 samples of human bladder cancer, especially the tiny miRNA, hsa-miR-146a is overexpressed in the most metastatic tumors. The molecule tells its mRNA partner to manufacture genes in a way that makes bladder cancer metastatic.

"Not only did we discover one specific molecule involved in bladder cancer metastasis, but we discovered a host of miRNA and mRNA pairs that bear further study," says Dan Theodorescu, MD, PhD, director of the CU Cancer Center and the paper's senior author.

Consider this: researchers used to data-mine tumor genomes for mutated genes that could cause cancer. Then researchers discovered that even healthy genes turned on and off or over/under-expressed at unfortunate times could cause cancer and so started looking for mRNA causes of this mis-expression. And now researchers including Theodorescu and colleagues are exploring a layer deeper to discover how miRNA affects mRNA, which affects gene expression, which causes cancer.

"You dig deep enough into these causal chains and you start to learn basic things about this disease and its progression," Theodorescu says.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Page: 1

Related biology news :

1. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
2. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
3. REACH news: European ombudsman takes up PETA complaint
4. Good news: Fewer maternal and child deaths
5. Cell therapy a little more concrete thanks to VIB research
6. Little did we know about beetle diversity: Astonishing 138 new species in a single genus
7. NTU researchers study little mighty creature for scientific breakthrough
8. Chemical fingerprinting tracks the travels of little brown bats
9. Variations of a single gene can lead to too much or too little growth, study shows
10. Enzymes allow DNA to swap information with exotic molecules
11. How the bodys energy molecule transmits 3 types of taste to the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... a non-traditional biophysics textbook and it describes how life ... of discovery into biological systems and provides an understanding ... is about how our genes make proteins that control ... cells in an organism. It quantifies the principles of ... be found on both large and small scales. The ...
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2
... of American Societies for Experimental Biology (FASEB) announces ... Conference (SRC): Matricellular Proteins in Development, Health, and ... extracellular matrix (ECM) are the basis for multi-cellular ... in all metazoan organisms. Structural ECM components such ...
... Societies for Experimental Biology (FASEB) announces the opening ... Mechanisms in Plant Development Conference. The 2013 ... and unique scientific conference where the intersections of ... through formal talks, poster sessions, and intensive scientific ...
... Two wasp species , Calymmochilus dispar and ... on ant-eating spiders in a study published in the ... spider, Zodarion styliferum , belongs to the largest genus ... and North Africa, significantly with at least 35 species reported ...
Cached Biology News:FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease 2Survival of the fittest: Predator wasps breed at the expense of spider juveniles 2
(Date:10/19/2014)... NextCODE Health, which enables clinicians and researchers to ... today announced the launch of its new genomic data analysis ... American Society of Human Genetics (ASHG) annual meeting in ... and apply for free beta access, visit www.nextcode.com . ... be viewed here . The Exchange: ...
(Date:10/19/2014)... October 19, 2014 The report "Chocolate, ... Share, Trade, Prices, Geography Trend and Forecast (2011 - ... category, and geography and studies the major market drivers, ... America, Europe, and Asia. , The global chocolate market ... $98.3 billion in 2016 at an estimated CAGR of ...
(Date:10/18/2014)... October 19, 2014 The “Human ... Acting, Intermediate Acting, Premixed), Modern Human Insulin (Rapid ... Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast to ... drivers, restraints, challenges, opportunities, current market trends, and ... with the estimates and forecasts of the revenue ...
(Date:10/18/2014)... The Asia-Pacific hardware encryption display market report defines and ... forecast of revenue. This market was valued $5,154.0 million ... by 2018, at a CAGR of 58.4% from 2013 ... Asia-Pacific hardware encryption market report, to get an idea ... glimpse of the segmentation of the market, and is ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3
... busy at the BIO Chicago industry show this week. Rather ... pen or kangaroo lapel pin, he met with more than ... mostly in prearranged sessions designed to help attendees make the ... of NeoClone , which manufactures monoclonal antibodies. It was ...
... some prominent customers led to a new high in ... of 2006, the company reported Wednesday. , ,Specific figures ... quarter by exceeding expectations in license sales, services business, ... established in the fourth quarter of 2005. The company ...
... representatives from Japan, the second-largest biotech market in ... BIO convention, you might not think they would ... a show of Wisconsin's international partnerships in biotechnology, ... at the Japan international session. And speaker Tsuney ...
Cached Biology Technology:Partner program is highlight of BIO for Wisconsin firm 2Japanese delegates highlight Wisconsin at BIO Chicago 2Japanese delegates highlight Wisconsin at BIO Chicago 3
Recombinant Mouse Noggin...
... Kit Kit Includes: Histone Deacetylase ... Histone Deacetylase 3 (HDAC3) Antibody, Catalog #2632, ... Catalog #2072, 40 ul Histone Deacetylase 5 ... Deacetylase 6 (HDAC6) Antibody, Catalog #2162, 40 ...
An instrument that delivers an accurate and uniform amount of light energy to cells to photoactivate csiRNA products....
... seals labware. Waterproof, moisture-proof film prevents ... Can be folded repeatedly and twisted ... lengthwise at 21C (70F), wrapping film ... is removed, film only partially returns ...
Biology Products: