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AACR news: K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer
Date:4/9/2013

sarcoma cell lines, finding an average 14-fold increase in expression compared to samples of healthy bone. Specifically, the group found that mRNA and protein expression linked to the influence of IGF2BP1 was highest in the most metastatic of these five human cell lines.

When Duval knocked down the expression of IGF2BP1, she found a three-fold decrease in the proliferation of these cells and increased sensitivity to chemotherapy with doxorubicin. The same technique produced similar results in mouse models of the disease without IGF2BP1, mouse models developed fewer, smaller tumors.

"It's an exciting finding and one with important clinical potential," Duval says.

Though further work is needed to validate IGF2BP1 as a marker and target for controlling the metastasis of pediatric bone cancer, and to identify clinically appropriate ways of targeting the molecule or its gene expression pathway, Duval is optimistic that this first step will result in improved care for the pediatric osteosarcoma patients who remain at the highest risk.


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

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