Navigation Links
AACR news: K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer
Date:4/9/2013

sarcoma cell lines, finding an average 14-fold increase in expression compared to samples of healthy bone. Specifically, the group found that mRNA and protein expression linked to the influence of IGF2BP1 was highest in the most metastatic of these five human cell lines.

When Duval knocked down the expression of IGF2BP1, she found a three-fold decrease in the proliferation of these cells and increased sensitivity to chemotherapy with doxorubicin. The same technique produced similar results in mouse models of the disease without IGF2BP1, mouse models developed fewer, smaller tumors.

"It's an exciting finding and one with important clinical potential," Duval says.

Though further work is needed to validate IGF2BP1 as a marker and target for controlling the metastasis of pediatric bone cancer, and to identify clinically appropriate ways of targeting the molecule or its gene expression pathway, Duval is optimistic that this first step will result in improved care for the pediatric osteosarcoma patients who remain at the highest risk.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Good news: Fewer maternal and child deaths
2. REACH news: European ombudsman takes up PETA complaint
3. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
4. AACR news: Six2 homeoprotein allows breast cancer cells to detach and metastasize
5. AACR news: Little molecule makes big difference in bladder cancer metastasis
6. AACR news: New target plus new drug equals death of melanoma cells
7. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
8. BGI Tech develops whole exome sequencing analysis of FFPE DNA samples to boost biomedicine
9. NSF-funded team samples Antarctic lake beneath the ice sheet
10. UT Arlington engineer wins NSF award to support microfluidic analyses of tissue, cell samples
11. Beyond the microscope: Identifying specific cancers using molecular analysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The Mills Canyon fire started near the City of ... of local resources, the fire quickly grew to over ... cause of the fire is under investigation by the ... is working with existing local resources in developing fire ... Forest Service (USFS), Washington State Department of Natural Resources, ...
(Date:7/11/2014)... When researchers at the National Institute of Standards ... do their work more effectively, they often prove ... Such was the case recently for M. Lorna ... in the growing specialization of glycomics. Glycomics is ... called glycans that are attached to proteins and ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... of green tea could prove the perfect elixir for ... bacterial infection. In a new laboratory study, Haichao Wang, ... his colleagues have been studying the therapeutic powers of ... immune response that kills 225,000 Americans every year. They ...
... , Detergents are a pollutant agent which can be found ... of chemical components to the soils. Two primary ways are the ... of fertilizers based out of biological mixtures. A study done by ... Microbiology at the University of Granada, directed by Dr. ...
... (November 8, 2007)- There is a new reason for the ... Vitamin D, a key nutrient in milk, could have aging ... published in the American Journal of Clinical Nutrition. In ... ages 19-79, British and American researchers found that higher vitamin ...
Cached Biology News:In the laboratory, green tea proves a powerful medicine against severe sepsis 2Chemical compound present in detergents produce bacteria alterations in agricultural soils 2Could vitamin D, a key milk nutrient, affect how you age? 2
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
(Date:7/10/2014)... According to the International Atomic Energy Agency (IAEA) ... terrorists acquiring sufficient quantities of plutonium or highly ... explosive device. The IAEA also notes that most ... quantities, which can be challenging to detect with ... study appearing this week in the Journal ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2
... Technology students at Chippewa Valley Technical College in Eau ... and micro-level surface analysis to firms or organizations ... Hans Mikelson says three students will comprise each of ... Mikelson believes that firms considering the purchase of ...
... Facilities, Inc. , a global leader in the design, ... and security systems, announced today that it has been ... the City of Madison, Wisconsin's proposed municipal Wi-Fi network. ... coordination with Madison Gas & Electric, WFI will deploy ...
... Wis. RedPrairie ... technology solutions provider that enables ... that 55 percent of the ... DLx Labor Workforce Performance Management ...
Cached Biology Technology:
... Electron's CryoMed Freezers for IVF are designed ... precise control, ease of setup and operation, ... operation status are continuously displayed on the ... cycle data are printed by way of ...
6 x Blend of rTth DNA Polymerase and Tli to provide optimized amounts of both 5-3 and 3-5 proofreading activity...
... is a recombinant Moloney murine leukemia ... Transcriptase is similar to MuLV reverse ... usage. MuLV reverse transcriptase is a ... single-stranded RNA as a template in ...
... Collection of Cell Cultures (ECACC) in conjunction ... the West of England, Bristol, UK, have ... control of HER2, oestrogen and progresterone receptor ... sections of formalin fixed, breast cancer cell ...
Biology Products: