Navigation Links
AACR names Perou 2009 Outstanding Investigator for Breast Cancer Research
Date:12/7/2009

CHAPEL HILL, NC Calling his work "one of the most important findings in breast cancer and health disparities in the last decade," the American Association for Cancer Research (AACR) has named Charles M. Perou, Ph.D. the 2009 Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen for the Cure.

Perou, who is an associate professor of genetics, pathology & laboratory medicine, and a member of UNC Lineberger Comprehensive Cancer Center, will present an invited lecture this week at the 32nd Annual San Antonio Breast Cancer Symposium and receive an honorarium.

Perou's work sets the stage to redefine breast cancer into multiple subtypes of disease. His findings are causing the entire field to reevaluate all preconceived notions regarding what causes breast cancer and how to treat it. Recognition of his accomplishments by AACR and Komen demonstrate the power of his ideas and their rapid acceptance by the scientific and clinical communities.

Perou's research crosses the disciplines of biology, genetics, bioinformatics, epidemiology and the clinical treatment of breast cancer. His major contribution to the field has been leading a team that has characterized the diversity of breast tumors and classified them in a way that helps physicians better understand why some cancers do not respond to standard therapies and to tailor treatment to the patient's disease type.

He and his colleagues have demonstrated that breast tumors can be classified into five molecular subtypes, with his lab focusing particular attention on the basal-like tumor subtype, which has a poor prognosis when given standard therapy. He is also currently studying the mechanisms that give rise to each tumor subtype, why some subtypes respond to chemotherapy and others do not, and he is using animal models and human clinical trials samples to develop new therapies targeted to each of the different subtypes.

With UNC Lineberger members Dr. Bob Millikan, who is the Barbara Sorenson Hulka Distinguished Professor of Epidemiology in the Gillings School of Global Public Health, and Dr. Lisa Carey, associate professor of hematology/oncology and director of the UNC Breast Center, Perou has translated these molecular subtypes to the wider patient population. Using a North Carolina-based study of a population-representative breast cancer patient set, this team found that pre-menopausal African American women are diagnosed with one particular subtype, the basal-like tumor, twice as often as their Caucasian counterparts providing significant insight into racial disparities that have long been known to exist in breast cancer mortality. Ongoing work is demonstrating that each breast cancer subtype has distinct risk factors.

In presenting the award, AACR notes that Perou's laboratory discoveries are being incorporated into clinical practice the treatment of patients worldwide. The organization also cites his international leadership in bioinformatics analysis of gene expression data and notes that these techniques will help researchers better compare animal models of cancer with those in humans, potentially speeding up preclinical trials of new therapeutic agents.


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert  

Related biology news :

1. Entomological Society of America names 2009 award winners
2. Biophysical Society names 2010 award recipients
3. Entomological Society of America names 2009 Fellows
4. Technology Review names Carnegie Mellons Treuille as a top young innovator
5. Impact Factor names Cell top research journal
6. UC Riverside researcher names lichen after President Barack Obama
7. AIBS names 2009 emerging public policy leaders
8. Names turn preschoolers into vegetable lovers
9. WCC Smart Search & Match Names Tarvinder Sembhi as VP Sales for the ID Market
10. WCC Smart Search and Match Names Rudie Lion - Product Marketing Manager
11. WCC Smart Search and Match Names Rudie Lion - Product Marketing Manager
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
AACR names Perou 2009 Outstanding Investigator for Breast Cancer Research
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
Breaking Biology Technology: