Navigation Links
A warm sensor maintains skin barrier
Date:5/14/2010

Japanese research group led by Prof. Makoto Tominaga and Dr. Takaaki Sokabe (National Institute for Physiological Sciences: NIPS) found that TRPV4 ion channel in skin keratinocytes is important for formation and maintenance of barrier function to prevent dehydration. Their finding was reported in the Journal of Biological Chemistry.

TRPV4 is one of the temperature-sensitive Ca2+-permeable channels, namely "thermoTRPs". It is expressed in skin, acting as a warm sensor (>27oC) to choose preferred environmental temperatures in mammals. The research group sought the alternative function of TRPV4, since skin keratinocytes express another thermoTRP named TRPV3, which also functions as a warm sensor.

TRPV4 was found to interact with b-catenin, an adaptor protein between actin filaments and E-cadherin in cell-cell junction complex. When TRPV4 was genetically removed from keratinocytes, Ca2+-induced cell-cell junction formation was delayed and immature, resulting in leaky junctions. Consistently, intercellular junction-dependent skin barrier in TRPV4-deficient mice became weak (leaky intercellular pathway) compared to wild-type mice. Interestingly, these phenotypes were TRPV4-specific, but not TRPV3-dependent.

Dr. Sokabe said, "TRPV4 may utilize skin temperature to provide Ca2+ for cell-cell junction complexes to reinforce their tightness. For instance, dried skin in cold seasons or regions could be due to low activity of TRPV4 caused by low skin temperature. Development of chemicals modulating TRPV4 activity would be useful for barrier repair of damaged skin."


'/>"/>

Contact: Dr. Takaaki Sokabe
sokabe@nips.ac.jp
81-564-595-287
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. Impact sensor provides athletic support
2. Tiny sensors tucked into cell phones could map airborne toxins in real time
3. UCLA researchers show how worlds smallest coffee ring may help biosensors detect disease
4. Sensor gives valuable data for neurological diseases and treatments
5. NIDCD-funded chemosensory researchers present findings at AChemS 2010 Meeting
6. Researchers equip robot sub with sensory system inspired by blind fish
7. New sensor array detects single molecules for the first time
8. Diffusion of a soluble protein through a sensory cilium
9. Small liquid sensor may detect cancer instantly, could lead to home detection kit
10. New ORNL sensor exploits traditional weakness of nano devices
11. Conference to discuss future of nanotechnology enabled sensors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... 18, 2014 Elsevier, a world-leading provider of ... and the Australasian Research Management Society (ARMS), recognized ... at the 5th Scopus Young Researcher of the ... today at the National Convention Centre and in ... attended by guests representing Australia,s and New Zealand,s ...
(Date:9/18/2014)... the ideal animal in which to study the genes ... into tens of thousands of freshwater streams and lakes ... adapt to the new environment. , Breeding studies between ... up one of the genes that controls tooth number, ... regulation in a freshwater population is associated with a ...
(Date:9/18/2014)... has found clownfish larvae can swim up to 400 kilometres ... to cope with environmental change. , Clownfish spend their entire ... as babies they must wander the open ocean, says study ... for Coral Reef Studies (Coral CoE) at James Cook University. ... but now we,ve been given a rare glimpse into how ...
Breaking Biology News(10 mins):Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3Nemo's epic journey to find a new home 2
... ANU Vice-Chancellor, Professor Ian Young AO, has just published ... surf report. Research led by the Vice-Chancellor will ... at which ocean swells decay, or deteriorate, as they ... oil and gas production, and even recreational activities such ...
... recently awarded a $449,641 grant by the Institute of Museum ... crowd sourcing and gaming to support the enhancement of texts ... December 2013 and ends in December 2015. The Garden will ... Botanical Garden on the project. , The BHL is ...
... goes: "Don,t judge a book by its cover." Well, the ... are the most common and well-known of their kind ... might look similar to another, when you take a closer ... differences. In fact, a recently published study in the ...
Cached Biology News:VC predicts the motion of the ocean 2Missouri Botanical Garden aims to improve access to digital texts through online gaming 2Dolphin genetic study provides revelations 2
(Date:9/19/2014)... LONDON , September 19, 2014 ... Spain , available today on PharmaBoardroom.com ... of the Eurozone crisis that rocked the Spanish economy in ... the Spanish pharma community has remained pragmatic in times of ... is still the fifth biggest European market, and the ...
(Date:9/18/2014)... 18, 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep ... Industry" and "2014 Deep Research Report on Global ... research database. Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... on Global and China Acetic Acid Industry" is ... China and Global Acetic Acid ...
(Date:9/18/2014)... 2014 Texas Governor Rick Perry, ... A&M Health Science Center CEO Brett Giroir, M.D., ... and Human Services (HHS), State of Texas and ... influenza vaccine manufacturing facility in Bryan, Texas, which ... the Texas A&M Biocorridor – a rapidly evolving ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... Albumin Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... The report provides a basic overview of the ... The human albumin market analysis is provided for the ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3
... Inc., a privately held clinical stage biotechnology company focused ... to address the unmet medical need of preventing recurrent ... portion of the Small Business Innovation Research Grant (SBIR) ... Streamlined Non-competing Award Procedures (SNAP). The initial year 1 ...
... Mont., April 8, 2011 Bacterin International Holdings, Inc. ... of revolutionary bone graft material, filed its 2010 Annual ... filing are certain non-recurring, non-cash charges in the fourth ... cash expenses by approximately $1.2 million from the financial ...
... On April 12, at the Hilton San Francisco Union Square, ... Bio Innovations (MBI), will address Agriculture 2.0 ... topic of ,Feeding a Growing Global Population,. The discussion will ... producing enough food to feed a projected world population of ...
Cached Biology Technology:MabVax Therapeutics Receives $1.8 Million in a Phase 2 Small Business Innovation Research Program Award From the National Cancer Institute 2MabVax Therapeutics Receives $1.8 Million in a Phase 2 Small Business Innovation Research Program Award From the National Cancer Institute 3Bacterin International Updates Fourth Quarter and Full Year 2010 Financial Results 2Bacterin International Updates Fourth Quarter and Full Year 2010 Financial Results 3Pam Marrone to Speak at Ag 2.0 Conference 2
... Forma stacking shakers have ... top speed stacked 3-high, and ... for sensitive "soft shake" applications. ... components and systems, our stackers ...
CQCS kit for first KR 4i , (first unit)....
Multidrop Micro high speed 1 l bulk reagent dispenser rapidly, precisely and accurately dispenses microvolumes of 1-50 l into 384- and 96-well microplates....
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
Biology Products: