Navigation Links
A urine test for appendicitis?
Date:6/22/2009

Appendicitis is the most common childhood surgical emergency, but the diagnosis can be challenging, especially in children, often leading to either unnecessary surgery in children without appendicitis, or a ruptured appendix and serious complications when the condition is missed. Now, emergency medicine physicians and scientists at the Proteomics Center at Children's Hospital Boston demonstrate that a protein detectable in urine might serve as a "biomarker" for appendicitis. Their report was published online June 23 by the Annals of Emergency Medicine.

Despite improvement in imaging technologies, recent figures indicate that 3 to 30 percent of children have unnecessary appendectomies, while 30 to 45 percent of those diagnosed with appendicitis already have a ruptured appendix. Laboratory biomarkers have been identified, but none have proved reliable enough to be clinically useful. Researchers led by Richard Bachur, MD, acting chief of emergency medicine at Children's Hospital Boston, Hanno Steen, PhD, director of the Proteomics Center, and clinical fellow Alex Kentsis, MD, PhD, decided to take a systematic approach, performing a proteomics study using state-of-the are mass spectrometry (a technique that detects and quantifies proteins in a sample). Their two-part study has identified the most accurate biomarker for acute appendicitis known to date.

In the first phase, they examined 12 urine specimens 6 from patients with appendicitis, taken before and after appendectomy, and 6 from patients without appendicitis and identified 32 candidate biomarkers, including many proteins associated with immune response and inflammation. To these 32 they added other candidates found through gene expression studies and other means, yielding a total of 57 potential biomarkers. They then sought to validate these markers in 67 children seen at the hospital for suspected appendicitis over an 18-month period, 25 of whom ultimately had proven appendicitis.
'/>"/>

Contact: James Newton
james.newton@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... N.C. -- A study of dominance in female baboons suggests ... close ties with mom, and to have lots of supportive ... by size or strength, but by the rank of her ... her daughter will be. For this reason, dominance rank in ... born to high-ranking mothers are guaranteed a good spot in ...
(Date:7/30/2014)... by Clemson University associate professor Andrew S. Mount, performed ... the way for novel anti-fouling paint for ships and ... applications. , The team,s findings, published in ... of barnacles that attaches to a wide variety of ... acts as an underwater heavy-duty adhesive. , "In previous ...
(Date:7/30/2014)... New York , July 30, 2014 /PRNewswire/ ... research on Global Government Biometric Systems Market ... The Global Biometric Systems Market 2014-2024" ... biometric systems market over the next ten years, ... using detailed market size forecasts. To ...
Breaking Biology News(10 mins):Supportive moms and sisters boost female baboon's rank 2Supportive moms and sisters boost female baboon's rank 3Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10
... mysterious invader washed upon the New Jersey shore. The Asian ... it found its new home to be quite agreeable. More ... has expanded its range along the Atlantic coast northward to ... expand, and wildlife biologists have found them in greater densities ...
... in <A HREF=",http://chinese.eurekalert.org/zh/emb_releases/2010-05/niom-rfl051310.php,">Chinese . , Scientists ... resilience to stress, vulnerability to depression and how ... circuit of mouse and human brains, have spurred ... the action of a key gene regulator there, ...
... its first full day with the announcement of the 2010 ... by Harold Varmus, co-chair of President Obama,s Council of Advisors ... of the announcement of the laureates by the Norwegian Academy ... discussion follows, moderated by Elizabeth Vargas of ABC News and ...
Cached Biology News:Are invasives bad? Not always, say Brown researchers 2Resilience factor low in depression, protects mice from stress 2Resilience factor low in depression, protects mice from stress 3
(Date:7/30/2014)... Columbia, MD (PRWEB) July 30, 2014 ... announces today the release of the REVELERIS® ... allows organic chemists, preparative chromatographers, and other researchers ... (LC) using a single unit. , With the ... between flash and preparative chromatography modes with a ...
(Date:7/30/2014)... July 30, 2014  Replikins Ltd. today released new ... Ebola virus. Before the current outbreaks, the mean Ebola ... amino acids) between 1995 and 2002 was 1.1; the ... 2012, and sixteen-fold in 2013, thus predicting the current ... technology has been shown to be able to predict ...
(Date:7/30/2014)... 30, 2014   Wyle has been ... Lifecycle Mission Support Services (FILMSS) contract awarded by ... the terms of the contract, Wyle will provide ... Field, Calif. In particular, Wyle will provide program ... projects on the International Space Station and collaborative ...
(Date:7/30/2014)... July 30, 2014 Vycom announces the ... products, designed to meet Factory Mutual (FM) 4910 fire ... such as wet benches, process tools, fume hoods, furniture ... and damage to semiconductor wafers used in electronic chip ... flame-retardant PVC solution with excellent workability and superior aesthetics. ...
Breaking Biology Technology:Grace Launches New REVELERIS® Prep Purification System 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2
... 2011 Although top bio-pharmaceutical companies agree that Key ... of a new product, increasing competition has made it ... the role of Medical Science Liaisons (MSLs) in forging ... recent years. In fact, today, ...
... YORK, March 21, 2011 Reportlinker.com announces that ... its catalogue: Global Nanobiotechnology Industry ... This report analyzes the worldwide markets for Nanobiotechnology ... - Nanomaterials (Solid Inorganic Nanoparticles, Nanocomposites, Nanostructured Materials ...
... China PharmaHub Corp. (OTC Bulletin Board: CPHB ... that it has signed a exclusive worldwide license agreement ... develop, commercialize and market a universal donor blood product ... Professor of Medicine and Pediatrics Dr. Ewa Carrier. The ...
Cached Biology Technology:Newly Updated for 2011: Medical Science Liaison Study Shows Growth in KOL Outreach, Impact 2Reportlinker Adds Global Nanobiotechnology Industry 2Reportlinker Adds Global Nanobiotechnology Industry 3Reportlinker Adds Global Nanobiotechnology Industry 4Reportlinker Adds Global Nanobiotechnology Industry 5Reportlinker Adds Global Nanobiotechnology Industry 6Reportlinker Adds Global Nanobiotechnology Industry 7Reportlinker Adds Global Nanobiotechnology Industry 8Reportlinker Adds Global Nanobiotechnology Industry 9Reportlinker Adds Global Nanobiotechnology Industry 10Reportlinker Adds Global Nanobiotechnology Industry 11Reportlinker Adds Global Nanobiotechnology Industry 12Reportlinker Adds Global Nanobiotechnology Industry 13Reportlinker Adds Global Nanobiotechnology Industry 14Reportlinker Adds Global Nanobiotechnology Industry 15Reportlinker Adds Global Nanobiotechnology Industry 16Reportlinker Adds Global Nanobiotechnology Industry 17China PharmaHub In-Licenses Universal Donor Red Blood Cells Technology Exclusively From University of California, San Diego 2
...
Request Info...
Spaced cover glasses to promote effective hybridization...
... D-LUX Detection Platform combines robust chemistry ... most sensitive, specific, and cost-effective detection ... Detection Platform offers exceptional performance with ... probes, high signal/background ratio, and an ...
Biology Products: