Navigation Links
A unique on-off switch for hormone production
Date:2/22/2012

After we sense a threat, our brain center responsible for responding goes into gear, setting off a chain of biochemical reactions leading to the release of cortisol from the adrenal glands.

Dr. Gil Levkowitz and his team in the Molecular Cell Biology Department have now revealed a new kind of ON-OFF switch in the brain for regulating the production of a main biochemical signal from the brain that stimulates cortisol release in the body. This finding, which was recently published in Neuron, may be relevant to research into a number of stress-related neurological disorders.

This signal is corticotropin releasing hormone (CRH). CRH is manufactured and stored in special neurons in the hypothalamus. Within this small brain region the danger is sensed, the information processed and the orders to go into stress-response mode are sent out. As soon as the CRH-containing neurons have depleted their supply of the hormone, they are already receiving the directive to produce more.

The research on zebrafish was performed in Levkowitz's lab and spearheaded by Dr. Liat Amir- Zilberstein together with Drs. Janna Blechman, Adriana Reuveny and Natalia Borodovsky, and Maayan Tahor. The team found that a protein called Otp is involved in several stages of CRH production. As well as directly activating the genes encoding CRH, it also regulates the production of two different receptors on the neurons' surface for receiving and relaying CRH production signals in effect, ON and OFF switches.

The team found that both receptors are encoded in a single gene. To get two receptors for the price of one, Otp regulates a gene-editing process known as alternative splicing, in which some of the elements in the sequence encoded in a gene can be "cut and pasted" to make slightly different "sentences." In this case, it generates two variants of a receptor called PAC1: The short version produces the ON receptor; the long version, containing an extra sequ
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. European researchers harness unique properties of boron to develop new drugs and diagnostics
2. Caltech geobiologists discover unique magnetic death star fossil
3. GUMC and Oak Ridge National Labs announce unique research partnership
4. NC State takes research lead in protecting Puerto Ricos unique freshwater fisheries
5. Unique transatlantic tie-up to understand the aging process
6. Researchers find pathway and enzyme unique to tularemia organism
7. Rots unique wood degrading machinery to be harnessed for better biofuels production
8. Weizmann Institute scientists develop a unique approach for splitting water into hydrogen and oxygen
9. Climate change threatens Lake Baikals unique biota
10. New DNA and RNA aptamers offer unique therapeutic advantages
11. Unique winter-hardy hibiscus has roots with AgriLife Research scientist in Vernon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 20, 2014 George E. Fox, a John and Rebecca ... Houston (UH), was named a fellow in the International Society ... , Fox is one of four members two from ... chosen as fellows in 2014. Fellows are elected every three ... than 500 members from more than 20 countries, the ISSOL ...
(Date:8/20/2014)... of 158 pregnant teenagers in Rochester, NY, nearly half ... of ice, cornstarch, vacuum dust, baby powder and soap, ... , Moreover, such teens had significantly lower iron levels ... substances. , Pregnant teens, regardless of pica, are at ... iron deficiency and anemia. Low iron in pregnant teens ...
(Date:8/20/2014)... SALT LAKE CITY Researchers at Huntsman Cancer Institute (HCI) ... mutated forms of the gene that encodes BCR-ABL, the ... (CML). According to the American Cancer Society, nearly 6,000 ... , Drugs already in use, called tyrosine kinase inhibitors ... disease. They do not cure CML but control it ...
Breaking Biology News(10 mins):UH professor named fellow by International Astrobiology Society 2Pica in pregnant teens linked to low iron 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... Chironex species are among the most venomous animals in ... venom, though, which kills by rapidly punching holes in human ... according to research published December 12 in the open access ... University of Hawaii and colleagues. The researchers ...
... be some in that cookie? Now you can find out ... A team of researchers from the UCLA Henry Samueli School ... called the iTube, which attaches to a common cell phone ... the cell phone,s built-in camera, along with an accompanying smart-phone ...
... the Great Lakes, including phosphorus-rich Lake Erie, is an age-old ... of scientists, including Mercyhurst University biologist Steven Mauro, Ph.D. ... avian botulism are linked to Cladophora and scientific ... renewed attention in the nuisance algae. For Mauro, whose ...
Cached Biology News:Got food allergies? Thanks to UCLA, you can test your meal on the spot using a cell phone 2Got food allergies? Thanks to UCLA, you can test your meal on the spot using a cell phone 3Grant furthers Mercyhurst research for human pathogens in Great Lakes 2
(Date:8/20/2014)... could improve the health of your heart, researchers have ... used a standard TENS machine like those designed to ... tragus, the small raised flap at the front of ... , The stimulation changed the influence of the nervous ... that can drive failing hearts too hard. , Professor ...
(Date:8/19/2014)... 19, 2014 Shimadzu Scientific Instruments ... Prominence-i and Nexera-i, adding to the company’s extensive ... functionality, an intuitive operating environment, and full automation, ... efficient workflow for conventional to ultra-high-speed analysis. ... and intelligent design so users can begin building ...
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 Research ... Oxide Fuel Cells (SOFCs) - Global Strategic Business Report" ... the worldwide markets for Solid Oxide Fuel Cells (SOFCs) in ... US, Canada , Europe ... Annual estimates and forecasts are provided for the period 2012 ...
(Date:8/19/2014)... Md. , Aug. 19, 2014 CSSi, ... research industry, recently announced the formation of the company,s ... to announce the addition of Dr. William E. ... - http://photos.prnewswire.com/prnh/20140818/136957 The MCAB, ... a variety of therapeutic areas and set strategic goals ...
Breaking Biology Technology:'Tickling' your ear could be good for your heart 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3
... , PITTSBURGH, Dec. 8 The ... investments and customized company formation and business growth programs ... life sciences industry leaders have joined the PLSG,s Executive ... Residence (EIRs) are Maureen Peszko and Michael Lang. Pierre ...
... ... Lyric, World’s First Invisible Extended Wear Hearing Aid. , ... Newark, CA (PRWEB) December 8, 2009 -- Whether it’s a crackling ... one should have to miss out on the joyous sounds of the holidays. Lyric, ...
... strive to cool atoms down to ever more frigid temperatures, ... of measuring these extreme lows. Now a team of physicists ... low as tens of trillionths of a degree above absolute ... Physical Review Letters and highlighted with a Viewpoint ...
Cached Biology Technology:The Pittsburgh Life Sciences Greenhouse Announces Additions to Nationally Recognized Executive Program 2The Pittsburgh Life Sciences Greenhouse Announces Additions to Nationally Recognized Executive Program 3Lyric Presents the Sounds of the Season 2
...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
The AVR9-8 stream-select valve is a 9-port, 8-position valve for use with the BioLogic DuoFlow system. This valve is used for high-pressure stream selection....
... BioGenex Super Sensitive MultiLink IHC ... species-specific secondary antibodies, labeled with ... to the bound primary antibody, ... a Streptavidin-Enzyme conjugate. This kit ...
Biology Products: