Navigation Links
A tiny molecule may help battle depression
Date:6/8/2014

Levels of a small molecule found only in humans and in other primates are lower in the brains of depressed individuals, according to researchers at McGill University and the Douglas Institute. This discovery may hold a key to improving treatment options for those who suffer from depression.

Depression is a common cause of disability, and while viable medications exist to treat it, finding the right medication for individual patients often amounts to trial and error for the physician. In a new study published in the journal Nature Medicine, Dr. Gustavo Turecki, a psychiatrist at the Douglas and professor in the Faculty of Medicine, Department of Psychiatry at McGill, together with his team, discovered that the levels of a tiny molecule, miR-1202, may provide a marker for depression and help detect individuals who are likely to respond to antidepressant treatment.

"Using samples from the Douglas Bell-Canada Brain Bank, we examined brain tissues from individuals who were depressed and compared them with brain tissues from psychiatrically healthy individuals, says Turecki, who is also Director of the McGill Group for Suicide Studies, "We identified this molecule, a microRNA known as miR-1202, only found in humans and primates and discovered that it regulates an important receptor of the neurotransmitter glutamate".

The team conducted a number of experiments that showed that antidepressants change the levels of this microRNA. "In our clinical trials with living depressed individuals treated with citalopram, a commonly prescribed antidepressant, we found lower levels in depressed individuals compared to the non-depressed individuals before treatment," says Turecki. "Clearly, microRNA miR-1202 increased as the treatment worked and individuals no longer felt depressed."

Antidepressant drugs are the most common treatment for depressive episodes, and are among the most prescribed medications in North America. "Although antidepressants are clearly effective, there is variability in how individuals respond to antidepressant treatment," says Turecki, "We found that miR-1202 is different in individuals with depression and particularly, among those patients who eventually will respond to antidepressant treatment".

The discovery may provide "a potential target for the development of new and more effective antidepressant treatments," he adds.


'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert  

Related biology news :

1. A new molecule for high-resolution cell imaging
2. JILA study finds crowding has big effects on biomolecules
3. Chemists design molecules for controlling bacterial behavior
4. Scientists from USC and NYU design a molecule that blocks cancer growth in mice
5. Researchers find new molecule to treat asthma
6. Scientists discover a natural molecule to treat type 2 diabetes
7. Conducting polymer films decorated with biomolecules for cell research use
8. Soy sauce molecule may unlock drug therapy for HIV patients
9. New discovery: Molecule links asthma and cancer and could aid in developing new treatments
10. NeuroPhage discovers GAIM-changing molecules to combat Alzheimers and related diseases
11. The 2nd International Symposium on Transformative Bio-Molecules 2014
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A tiny molecule may help battle depression
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by Solution ... Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to 2022", ... 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at a ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... NC (PRWEB) , ... August 15, 2017 , ... ... 2017, celebrating 10 years of successes helping medical technology companies and inventors develop and ... to a renowned full-service national engineering firm with a portfolio of clients in the ...
(Date:8/15/2017)... , ... August 15, 2017 , ... ... the largest Asian exhibitions for analytical and scientific instruments. This year’s symposium, organized ... “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... new family of 6” modular downlights designed to stay tightly sealed and perform ... areas where damp and wet location listings just aren't enough, such as: hospitals; ...
(Date:8/15/2017)... ... 15, 2017 , ... Coffea arabica accounts for 70 percent ... During this educational webinar, participants will learn about the importance of genomics for ... understanding of how genomics is important for coffee breeding improvement. , Attendees will ...
Breaking Biology Technology: