Navigation Links
A tiny molecule may help battle depression
Date:6/8/2014

Levels of a small molecule found only in humans and in other primates are lower in the brains of depressed individuals, according to researchers at McGill University and the Douglas Institute. This discovery may hold a key to improving treatment options for those who suffer from depression.

Depression is a common cause of disability, and while viable medications exist to treat it, finding the right medication for individual patients often amounts to trial and error for the physician. In a new study published in the journal Nature Medicine, Dr. Gustavo Turecki, a psychiatrist at the Douglas and professor in the Faculty of Medicine, Department of Psychiatry at McGill, together with his team, discovered that the levels of a tiny molecule, miR-1202, may provide a marker for depression and help detect individuals who are likely to respond to antidepressant treatment.

"Using samples from the Douglas Bell-Canada Brain Bank, we examined brain tissues from individuals who were depressed and compared them with brain tissues from psychiatrically healthy individuals, says Turecki, who is also Director of the McGill Group for Suicide Studies, "We identified this molecule, a microRNA known as miR-1202, only found in humans and primates and discovered that it regulates an important receptor of the neurotransmitter glutamate".

The team conducted a number of experiments that showed that antidepressants change the levels of this microRNA. "In our clinical trials with living depressed individuals treated with citalopram, a commonly prescribed antidepressant, we found lower levels in depressed individuals compared to the non-depressed individuals before treatment," says Turecki. "Clearly, microRNA miR-1202 increased as the treatment worked and individuals no longer felt depressed."

Antidepressant drugs are the most common treatment for depressive episodes, and are among the most prescribed medications in North America. "Although antidepressants are clearly effective, there is variability in how individuals respond to antidepressant treatment," says Turecki, "We found that miR-1202 is different in individuals with depression and particularly, among those patients who eventually will respond to antidepressant treatment".

The discovery may provide "a potential target for the development of new and more effective antidepressant treatments," he adds.


'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert  

Related biology news :

1. A new molecule for high-resolution cell imaging
2. JILA study finds crowding has big effects on biomolecules
3. Chemists design molecules for controlling bacterial behavior
4. Scientists from USC and NYU design a molecule that blocks cancer growth in mice
5. Researchers find new molecule to treat asthma
6. Scientists discover a natural molecule to treat type 2 diabetes
7. Conducting polymer films decorated with biomolecules for cell research use
8. Soy sauce molecule may unlock drug therapy for HIV patients
9. New discovery: Molecule links asthma and cancer and could aid in developing new treatments
10. NeuroPhage discovers GAIM-changing molecules to combat Alzheimers and related diseases
11. The 2nd International Symposium on Transformative Bio-Molecules 2014
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A tiny molecule may help battle depression
(Date:12/15/2016)... ... Research and Markets has announced the addition of the "Global ... The report forecasts the global military biometrics market to grow at a ... has been prepared based on an in-depth market analysis with inputs from ... over the coming years. The report also includes a discussion of the ...
(Date:12/12/2016)... CLEVELAND , Dec. 12, 2016  Researchers ... commercial possibilities for graphene by combining the material ... a highly sensitive pressure detector able to sense ... of a small spider.  The ... and can be read here:  http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/7/2016)... TEL AVIV, Israel , December 7, 2016 ... year with the expansion of its patent portfolio, which grew to over ... , , ... led by its recently filed patent entitled " System, Device, ... which covers technology that enables device makers to forego costly hardware components ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... January 12, 2017 , ... ... capable of performing routine electrochemical biosensing has increased dramatically. Primarily driven by ... detection and quantification of various analytes in complex samples. , ...
(Date:1/12/2017)... January 12, 2017 A new report published by Allied Market ... Global Opportunity Analysis and Industry Forecast, 2014-2022," projects that the global in vitro toxicity ... at a CAGR of 15.07% during the forecast period. ... ... ...
(Date:1/11/2017)... (PRWEB) , ... January 11, 2017 , ... ... rural and urban clinics in Peru studying the pathogens that cause malaria and ... on a career path of discovery. , Now, as an assistant professor of ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... scientific grants to ground-breaking microbiome studies. Its most recent microbiome impact grant award ... who will study the effect of long-term use of oral antibiotics, prescribed for ...
Breaking Biology Technology: