Navigation Links
A tiny molecule may help battle depression

Levels of a small molecule found only in humans and in other primates are lower in the brains of depressed individuals, according to researchers at McGill University and the Douglas Institute. This discovery may hold a key to improving treatment options for those who suffer from depression.

Depression is a common cause of disability, and while viable medications exist to treat it, finding the right medication for individual patients often amounts to trial and error for the physician. In a new study published in the journal Nature Medicine, Dr. Gustavo Turecki, a psychiatrist at the Douglas and professor in the Faculty of Medicine, Department of Psychiatry at McGill, together with his team, discovered that the levels of a tiny molecule, miR-1202, may provide a marker for depression and help detect individuals who are likely to respond to antidepressant treatment.

"Using samples from the Douglas Bell-Canada Brain Bank, we examined brain tissues from individuals who were depressed and compared them with brain tissues from psychiatrically healthy individuals, says Turecki, who is also Director of the McGill Group for Suicide Studies, "We identified this molecule, a microRNA known as miR-1202, only found in humans and primates and discovered that it regulates an important receptor of the neurotransmitter glutamate".

The team conducted a number of experiments that showed that antidepressants change the levels of this microRNA. "In our clinical trials with living depressed individuals treated with citalopram, a commonly prescribed antidepressant, we found lower levels in depressed individuals compared to the non-depressed individuals before treatment," says Turecki. "Clearly, microRNA miR-1202 increased as the treatment worked and individuals no longer felt depressed."

Antidepressant drugs are the most common treatment for depressive episodes, and are among the most prescribed medications in North America. "Although antidepressants are clearly effective, there is variability in how individuals respond to antidepressant treatment," says Turecki, "We found that miR-1202 is different in individuals with depression and particularly, among those patients who eventually will respond to antidepressant treatment".

The discovery may provide "a potential target for the development of new and more effective antidepressant treatments," he adds.


Contact: Cynthia Lee
McGill University

Related biology news :

1. A new molecule for high-resolution cell imaging
2. JILA study finds crowding has big effects on biomolecules
3. Chemists design molecules for controlling bacterial behavior
4. Scientists from USC and NYU design a molecule that blocks cancer growth in mice
5. Researchers find new molecule to treat asthma
6. Scientists discover a natural molecule to treat type 2 diabetes
7. Conducting polymer films decorated with biomolecules for cell research use
8. Soy sauce molecule may unlock drug therapy for HIV patients
9. New discovery: Molecule links asthma and cancer and could aid in developing new treatments
10. NeuroPhage discovers GAIM-changing molecules to combat Alzheimers and related diseases
11. The 2nd International Symposium on Transformative Bio-Molecules 2014
Post Your Comments:
Related Image:
A tiny molecule may help battle depression
(Date:11/17/2015)... , November 17, 2015 ... au 19 novembre  2015.  --> Paris ... --> DERMALOG, le leader de l,innovation biométrique, ... la fois passeports et empreintes sur la même surface ... les passeports et l,autre pour les empreintes digitales. Désormais, ...
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced expansion of its TDDI ... touch controller and display driver integration (TDDI) ... smartphones. These new TDDI products add to the ... resolution), TD4302 (WQHD resolution), and TD4322 (FHD resolution) ...
(Date:11/12/2015)... --  Growing need for low-cost, easy to use, ... the way for use of biochemical sensors for ... clinical, agricultural, environmental, food and defense applications. Presently, ... applications, however, their adoption is increasing in agricultural, ... on improving product quality and growing need to ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , November 24, 2015 ... market research report "Oligonucleotide Synthesis Market by Product & ... Gene Synthesis, Diagnostic, DNA, RNAi), End-User (Research, Pharmaceutical & ... by MarketsandMarkets, the market is expected to reach USD ... 2015, at a CAGR of 10.1% during the forecast ...
(Date:11/24/2015)... Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today announced that ... 2015 at 11:00 a.m. Israel time, at the ... Yigal Allon Street, 36 th Floor, Tel Aviv, Israel ... Paneth and Izhak Tamir to the Board of Directors; ... external directors; , approval of an amendment to certain terms of ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 list of ... OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds up orthodontic ...
(Date:11/24/2015)... , November 24, 2015 , ... a European healthcare fund ... companies will work closely together in identifying European breakthrough technologies ... need. The collaboration is underpinned by a significant investment by ... is the first investment by Bristol-Myers Squibb in a European ...
Breaking Biology Technology: