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A tall story: New research adds to growing body of knowledge of genetics of height
Date:4/6/2008

Scientists are beginning to develop a clearer picture of what makes some people stand head and shoulders above the rest. A team of researchers who last year identified the first common version of a gene influencing height has now identified a further twenty regions of the genome which together can make a height difference of up to 6cm.

The results, published together with two independent studies online today in the journal Nature Genetics, mean that scientists now know of dozens of genes and genetic regions that influence our height. This provides scientists with a fascinating insight into how the body grows and develops normally and may shed light on diseases such as osteoarthritis and cancer.

Unlike a number of other body size characteristics such as obesity, which is caused by a mix of genetic and environmental factors (so called "nature and nurture"), 90 per cent of normal variation in human height is due to genetic factors rather than, for example, diet. Last year, a team of researchers including Dr Tim Frayling from the Peninsula Medical School, Exeter, and Professor Mark McCarthy from the University of Oxford identified the first common gene variant to affect height, though it made a difference of only 0.5cm.

Now, using DNA samples from over 30,000 people, many taken from the Wellcome Trust Case Control Consortium the largest study ever undertaken into the genetics underlying common diseases and from the Cambridge Genetics of Energy Metabolism (GEM) consortium and the CoLaus Study in Switzerland, the researchers have identified 20 loci (regions of genetic code), common variations of which influence adult height.

"The number and variety of genetic regions that we have found show that height is not just caused by a few genes operating in the long bones" says Dr Frayling. "Instead, our research implicates genes that could shed light on a whole range of important biological processes.

"By identifying which gen
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Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

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