Navigation Links
A switch that controls whether cells pass point of no return
Date:3/23/2008

DURHAM, N.C. Investigators at the Duke Institute for Genome Sciences and Policy have revealed the hidden properties of an on-off switch that governs cell growth.

The Duke team proved that if the switch is on, then a cell will divide, even if its damaged or the signal to grow disappears. Showing how the switch works may provide clues to novel drug targets for cancer and other diseases in which cell growth goes awry.

The switch is part of a critical pathway that controls cell division, the process by which the body makes new cells. Before a cell starts to divide, it goes through a checklist to make sure everything is in order, much like preparing for a long trip. If a cell senses something is wrong early on, it can halt the process. But once a cell passes a milestone called the restriction point, theres no turning back, no matter the consequences. The switch controls this milestone and is key to cell growth.

The results will appear in the April issue of the journal Nature Cell Biology. The study was funded by the National Institutes of Health, the National Science Foundation and a David and Lucile Packard Fellowship.

The switch is part of the Rb-E2F signaling pathway. Rb, or retinoblastoma, is a key tumor suppressor gene, and E2F is a transcription factor that governs the expression of all the genes important for cells to grow.

The wiring diagram is fundamentally the same. Its very likely that different organisms have evolved a very conserved design principle to regulate their growth, said Guang Yao, Ph.D., lead study author and a postdoctoral fellow in Dukes department of molecular genetics and microbiology.

The cellular pathway that includes the switch is found in all multi-cellular life, from plants to people. A cell decides to trigger the pathway when it receives an external chemical signal to grow.

During the project, the researchers discovered the switch has an unexpected property: it is b
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Switching goals
2. Researchers find signal that switches on eye development -- could lead to eye in a dish
3. Researchers identify how to switch off cancer cell genes
4. Leading cause of death in preemies might be controlled by resetting a molecular switch
5. Why the switch stays on
6. Electronic switch opens doors in rheumatoid joints
7. Search for the on switches may reveal genetic role in development and disease
8. Circadian clock controls plant growth hormone
9. Too much sugar turns off gene that controls the effects of sex steroids
10. Technique controls nanoparticle size, makes large numbers
11. Protein controls blood vessel formation, offers new drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... and you,re likely to find that the lunches and snacks ... of a study conducted by researchers at the Friedman School ... the Department of Public Health and Community Medicine at Tufts ... ahead of print in the Journal of the Academy ... author Jeanne Goldberg, Ph.D., R.D., a professor at the Friedman ...
(Date:7/22/2014)... immune cell widely believed to exacerbate chronic adult ... sclerosis (MS), can actually protect the brain from ... progression of neurodegenerative diseases, according to Cleveland Clinic ... Nature Communications . , The research team, led ... of Neurosciences at Cleveland Clinic,s Lerner Research Institute, ...
(Date:7/21/2014)... Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the air ... virus. The work, published this week in mBio ... for Microbiology, indicates that further studies are needed to ... air. , MERS, a serious viral respiratory illness caused ... as of June 11, according to the World Health ...
Breaking Biology News(10 mins):Room for improvement in elementary school children's lunches and snacks from home 2Cleveland Clinic researchers discover neuroprotective role of immune cell 2Middle East Respiratory Syndrome coronavirus detected in the air of a Saudi Arabian camel barn 2
... a revolutionary approach to study microbes. Rather than isolating ... directly to environmental samples to obtain information about the ... habitat studied. The ocean is an ideal subject of ... equals that of all other living organisms on earth ...
... Representatives from the Midlands Consortium say they are ... has been chosen to host a new 1billion ... Midlands Consortium is comprised of the universities of ... all with extensive and complementary energy related research ...
... , Vancouver, B.C. - On Sept. 24, 2007, ... at the UBCM Pine Beetle Conference and will announce ... Beetle Program to help affected communities. Location: ... Canada Place Way, Vancouver, B.C. Date and ...
Cached Biology News:Metagenomics of the deep Mediterranean 2Midlands Consortium delighted to be chosen to host £1 billion energy institute 2Midlands Consortium delighted to be chosen to host £1 billion energy institute 3
(Date:7/22/2014)... FRANKLIN LAKES, N.J. , July 22, 2014 ... (NYSE: BDX ) has declared a quarterly dividend ... 2014 to holders of record on September 9, 2014. The ... About BD BD is a leading medical ... many of the world,s most pressing and evolving health needs. ...
(Date:7/22/2014)... mechanical engineering at the University of Texas at Dallas, ... North Texas section of the American Society of Mechanical ... in 158 countries who develop engineering standards and training. ... benefiting the world. , ASME recognized Baughn earlier this ... banquet. Baughn retired as an engineering fellow in 2012 ...
(Date:7/22/2014)... Automated cell culture systems are instruments ... culture. They allow production of optimum cells at a ... drug discovery and industries and biopharmaceutical companies. Cell culture ... research, cryobanking, cell-based assays, and cellular expression systems as ... forecast the Global Cell Culture market will ...
(Date:7/22/2014)... NJ (PRWEB) July 22, 2014 ... precision, portable, and mechanical balances and scales, proudly ... balances has won Laboratory Equipment magazine’s 2014 “Readers' ... the second consecutive year the Explorer was voted ... The annual Readers’ Choice Awards celebrates “excellence in ...
Breaking Biology Technology:UT Dallas professor receives Engineer of the Year award 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 4OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2
... Inc., a leader in material science and polymer extrusions, ... The standard was developed by The Society for Automotive ... This certification is merely one indication of Zeus, increased ... working directly with more suppliers to design end products ...
... study, entitled Sustainable Value in Automobile Manufacturing, looks ... manufacturers worldwide between 1999 and 2007. It has ... School in Belfast, in partnership with researchers from ... for Futures Studies and Technology Assessment (IZT) in ...
... CAMBRIDGE, Mass., Oct. 29 Idenix Pharmaceuticals, Inc. (Nasdaq: ... discovery and development of drugs for the treatment of ... has decided not to exercise its option to license ... for the treatment of HCV. As a result, ...
Cached Biology Technology:Zeus Increases Its Presence in Aerospace Industry with AS9100 Certification 2North America automobile sector bottom of 'world sustainability league' 2North America automobile sector bottom of 'world sustainability league' 3Idenix Retains Worldwide Rights to Develop and Commercialize IDX184 for the Treatment of HCV 2Idenix Retains Worldwide Rights to Develop and Commercialize IDX184 for the Treatment of HCV 3
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
BD BioCoat Fibronectin 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of human fibronectin....
... to Human Cytokeratin TYPE II Reacts ... keratins. Including epidermal cell keratin of 86 ... and 67kD. Broad keratin reactivity is found ... Immunogen: Human epidermal ...
BD BioCoat Fibronectin 150 mm Culture Dishes...
Biology Products: