Navigation Links
A study reveals how cells communicate to activate the cell division machinery
Date:5/5/2008

This release is available in Spanish.

A study performed by researchers at the Institute for Research in Biomedicine (IRB Barcelona) on the fruit fly, Drosophila melanogaster, unveils how distinct signaling pathways operate between neighboring cells in order to activate the cell proliferation machinery that results in the organized growth of the fly wing. The signaling pathways involved in this process are also conserved in humans, and when altered in diverse tissues give rise to the appearance of different types of cancer, including cancer of the colon and skin, and leukemia. The study has been undertaken in the Cell and Development Biology Laboratory headed by ICREA Research Professor, Marco Miln, at IRB Barcelona, and has been released in and advanced online format by the EMBO Journal.

The researchers have shown that the Notch and Wnt/Wingless signaling pathways exert control over the cell division machinery through two gene effectors, the proto-oncogen dMyc and the micro-RNA bantam. Regulated by Notch and Wnt/Wingless, these two genes instruct another gene, E2F, to activate the cell division machinery. All the components were already known but we have clarified the order in the signaling cascade and the interaction between the molecular elements that regulate proliferation for the correct development of the wing, explains Hctor Herranz, first author of the article.

Marco Miln: Diseases like cancer cannot be understood without taking into account how the distinct molecular elements are integrated.

Notch and Wnt/Wingless play a key role in embryo development, cell growth (proliferation) and the transformation of cells into specialized types (differentiation). The interesting feature is that these two pathways are highly conserved in humans and when mutations arise tumors appear. The fruit fly wing is a vital experimental model to find f
'/>"/>

Contact: Sonia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... New research presented at the Society for Integrative ... showed for the first time that it is ... a readily available nutritional supplement, AHCC. ... A. Smith, Pharm.D., associate professor in the Department ... University of Texas Health Science Center at Houston ...
(Date:10/29/2014)... to make their food, but they also need protection from ... a group of molecules in plants that shields them from ... of the American Chemical Society , one team reports on ... Timothy Zwier and colleagues at Purdue University note that the ... serious damage to plant DNA and, as a result, hinder ...
(Date:10/29/2014)... a ceremony held in New York City on September ... the American Cancer Society Professor of Genome Sciences and ... 2008 Honorary Doctor of Philosophy of Tel Aviv University, ... Medical Science. , In addition to her honorary degree ... at the TAU School of Medicine, and for the ...
Breaking Biology News(10 mins):HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2
... , No one is in a better position to monitor ... the people living there. But many scientists believe the ... is simply too great to bridge -- that native peoples ... But now, researchers led by Stanford ecologist Jose Fragoso have ...
... New research from the Universities of Portsmouth and Leicester has ... London as being part of a giant pterosaur ... and toothed animals. Dr David Martill from the University ... Leicester examined the fossil - which consisted of the tip ...
... eyes or legs, yet they are able to "see" and ... is controlled by a series of molecular-level signals between proteins ... The Plant Cell, University of Missouri scientists report ... plays in this molecular signaling pathway that regulates phototropism in ...
Cached Biology News:Can indigenous peoples be relied on to gather reliable environmental data? 2Can indigenous peoples be relied on to gather reliable environmental data? 3Tiny fossil fragment reveals giant-but-ugly-truth 2Tiny fossil fragment reveals giant-but-ugly-truth 3Protein plays role in helping plants see light 2
(Date:10/31/2014)... Brady (NYSE:BRC), a global leader in product and ... testimonial on the effectiveness of its FreezerBondz™ specimen ... the BloodCenter of Wisconsin discusses the challenges she faces ... thousands of samples, and how the durability of Brady’s ... design our label materials with the harsh conditions of ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 The report ... Chemicals), by Application (Cosmetics & Toiletries, and Soaps & ... to 2019”, has defined and segmented the Fragrance Ingredients ... trends in terms of value. The market has been ... North America, Europe, Asia-Pacific, Latin America, and Rest of ...
(Date:10/30/2014)... 30, 2014 On October 26th ... Showcase in Chicago, leading applied stem cell research ... Wade McKenna presented talks on New Techniques for ... Applications For Stem Cells. , Dr. Riordan focused ... the properties of AlphaGEMS that include: wound healing; ...
(Date:10/30/2014)... 30, 2014 Whitehouse Laboratories has formally ... Stability Testing and Package Test Capacity. Responding to growing ... a dramatic increase in environmental chamber storage space that ... and aging samples to be securely held on site ... capital expenditure has already taken place with the recent ...
Breaking Biology Technology:Brady Debuts New Lab Label Testimonial Video 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3
... two months ahead of schedule ... -, - Progress continues on LymphoStat-B, ABthrax and TRAIL receptor antibody ... programs - ... ROCKVILLE, Md., Nov. 1 Human Genome Sciences,Inc. (Nasdaq: HGSI ) today announced financial results ...
... CA -- Make way for the real nanopod and ... of researchers with the U.S. Department of Energys Lawrence ... California at Berkeley have created the first fully functional ... by several orders of magnitude the smallest radio ever ...
... - Dragon Pharmaceutical Inc.,(TSX: DDD; OTCBB: DRUG; ... method,for 7ACA production has been successfully implemented ... achievement validates the Company,s research,and development efforts ... bring immediate benefits to production operations by,increasing ...
Cached Biology Technology:Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 2Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 3Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 4Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 5Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 6Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 7Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 8Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments 9Make way for the real nanopod 2Make way for the real nanopod 3Make way for the real nanopod 4Dragon Announces R&D Achievement in Biotech Manufacturing Process 2Dragon Announces R&D Achievement in Biotech Manufacturing Process 3
IC50: 3 ng/ml · Limit of detection: 0.9 ng/ml...
Request Info...
Image Analysis Software. PC Version of NIH Image....
... the premium quality siRNAs you need for ... be readily ordered online by providing either ... providing the sense and antisense siRNA sequences. ... Silencer Pre-designed siRNAs, which are already designed ...
Biology Products: