Navigation Links
A stronger heart with flavonoids

A polyphenols-rich diet keeps the heart younger. This finding comes out from a study by the University of Grenoble in collaboration with the other Centres participating to the FLORA Project, a European Commission funded research studying the effects of flavonoids, a variety of polyphenols, on human health.

The scientific work, published in the Journal of Nutrition, is one of the few approaching this field by in vivo studies. So far- says Marie-Claire Toufektsian, leading author of the study- the biological and protective activities of various flavonoids have been extensively studied in vitro, on cell- based assays. Nevertheless, this kind of approach has a major limitation: it is extremely difficult to assess precisely the nature of all flavonoids absorbed following consumption of plants present in a given meal. In other words, laboratory cultured cells alone are not sufficient to study a complex mechanism such as that of absorption of food flavonoids. That is why we need to turn attention on other features. The most obvious solution appeared to be to study the effects of this kind of polyphenols on experimental animals. The turning point started from plants: those rich in flavonoids made the case of researchers.

Toufektsian used two kinds of corn: one anthocyanin-free (anthocyanins is a variety of flavonoids) and the other, obtained by the Department of Biomolecular Sciences and Biotechnology of University of Milan through traditional cultivation techniques with no transgenic modifications, rich in anthocyanins. The corn seeds were introduced into a rodent food formula in order to obtain two groups of rats following two different kinds of diet for a couple of months says Chiara Tonelli, head of the Milan group. In the meantime researchers accurately measured the anthocyanins levels in urine and plasma samples from the two groups of rats by using a method developed by the Research Laboratories at the Catholic University of Campobasso. Then researchers studied the onset and evolution of myocardial infarction induced experimentally in both groups.

We found Toufektsian adds that chronic consumption and effective absorption of anthocyanins rendered the rats more resistant to myocardial infarction; in other words, the size of the infarct was significantly reduced in rats fed the anthocyanin-rich diet.

The quantity of absorbed anthocyanins is important too. Maria Benedetta Donati, scientific coordinator of the Research Laboratories of Campobasso, argues that the rats fed the anthocyanin- rich diet received about 13- fold more anthocyanins than most people following a standard Western-type diet, where the daily consumption of flavonoids is relatively low and the average intake of anthocyanins is estimated to be only 12 mg per day.

The Authors turned their attention on Mediterranean diet stressing the crucial difference between this kind of diet and the so called Western Diet, that is rich in fats and poor in fibres. The anthocyanins content of the traditional Mediterranean diet is much higher than that of the Western Diet, which might explain why the Mediterranean diet is cardioprotective says Michel de Lorgeril, cardiologist, head of the Grenoble group.

However promising these results appear to be, researchers go easy on them. The cellular mechanisms of the protection are not clearly determined yet- Toufektsian warns- Moreover, there may be differences between humans and rats, for example in terms of flavonoid absorption and metabolism.

Human volunteers are the target of another phase of the FLORA Project. The Research Laboratories of the Catholic University of Campobasso are studying the process of absorption and metabolism of anthocyanins from blood orange juice- one of the most generous sources of flavonoids- in human body. In this way researchers aim at evaluating how these compounds are absorbed by human body to play their beneficial effects.

The FLORA Project

Funded by the European Commission within the 6th framework program, the FLORA Project aims at gaining further evidence on the dynamics triggered by flavonoids, establishing a forefront in Europe for the study of association among these compounds and cardiovascular disease, myocardial infarction and tumours. FLORA researchers are involved in the field of flavonoids contained in different vegetables, such as corn, tomatoes and an experimental plant called Arabidopsis. Oranges too are other protagonists of this study. They are rich in flavonoids and phenolics by their own nature. FLORAs oranges have something more: the amount of antioxidant has been enriched in order to optimize their natural beneficial effects. Moreover, these fruits are additive free and have been cultivated in full respect of healthy parameters. There is no risk of unexpected surprises but just a measured increase in terms of nutrition. Promoting health through a balanced and correct diet, in respect for different food tradition of European Countries, is the mission of FLORA.


Contact: Americo Bonanni
Catholic University

Related biology news :

1. Stronger EPA leadership needed to improve water quality in Mississippi River
2. Layered approach may yield stronger, more successful bone implants
3. New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets
4. Taking the fight against cancer to heart
5. New book gives a human face to children with congenital heart disease
6. Carbon monoxide may cause long-lasting heart damage
7. Worlds biggest heart model simulated at Université de Montréal
8. Scientists associate 6 new genetic variants with heart disease risk factor
9. Eat less or exercise more? Either way leads to more youthful hearts
10. The construction of heart modelling leads path to new therapies
11. Physician-scientist urges improved drug regulation to ensure heart safety of non-heart drugs
Post Your Comments:
(Date:10/29/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that it has ... as one of only three finalists for a ... and Growing" category. The Tekne Awards honor Minnesota ... technology innovation and leadership. iMedNet™ eClinical ...
(Date:10/29/2015)... -- Daon, a global leader in mobile biometric authentication ... version of its IdentityX Platform , IdentityX v4.0. ... have already installed IdentityX v4.0 and are seeing ... UAF certified server component as an option and ... These customers include some of the largest and most ...
(Date:10/29/2015)... 29, 2015  Connected health pioneer, Joseph C. ... of technology-enabled health and wellness, and the business opportunities ... The Internet of Healthy Things . Long ... even existed, Dr. Kvedar, vice president, Connected Health, Partners ... delivery, moving care from the hospital or doctor,s office ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Studies reveal the differences in species of bacteria ... for more effective treatment for one of the most commonly ... --> --> Gum disease is one ... relatively little was understood about the bacteria associated with it ... researchers from the WALTHAM Centre for Pet Nutrition together with ...
(Date:11/25/2015)... -- Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) today ... discussion at the Piper Jaffray 27th Annual Healthcare Conference ... is scheduled for Wednesday, December 2, at 8:00 a.m. ... will be available for 14 days after the event.  ... Corporate Communications and Business Development , BrewLife(858) 875-8629 ...
(Date:11/24/2015)... SUNNYVALE, Calif. , Nov. 24, 2015 ... executives will be speaking at the following conference, and ... New York, NY      Tuesday, December 1, ... New York, NY      Tuesday, December 1, ...      Piper Jaffray Healthcare Conference, New York, NY ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... IIROC on behalf of the Toronto Stock Exchange, confirms ... there are no corporate developments that would cause the ... --> --> About Aeterna Zentaris ... . --> Aeterna Zentaris is a specialty ...
Breaking Biology Technology: