Navigation Links
A step toward tissue-engineered heart structures for children
Date:9/12/2007

Infants and children receiving artificial heart-valve replacements face several repeat operations as they grow, since the since the replacements become too small and must be traded for bigger ones. Researchers at Childrens Hospital Boston have now developed a solution: living, growing valves created in the lab from a patients own cells.

In a special issue of Circulation published September 11, they describe making pulmonary valves through tissue engineering. These valves, which provide one-way blood flow from the hearts right ventricle into the pulmonary artery, are often malformed in congenital heart disease, putting an extra burden on the heart.

The heart valve is a complex organ, says Virna Sales, MD, a researcher in Childrens Department of Cardiac Surgery and the studys first author. It must open and close synchronously, withstand pressure, and be pliable and elastic. We are one of the few labs in the U.S. thats attempting to make heart valves through tissue engineering. We hope these could just be implanted in a child just once, instead of the many heart operations most children have to go through as they get older.

The researchers, led by Sales and senior investigator John Mayer, MD in Childrens Department of Cardiac Surgery, first isolated endothelial progenitor cells (precursors of the cells that line blood vessel walls) from the blood of laboratory animals. They then seeded the cells onto tiny, valve-shaped biodegradable molds and pre-coated with proteins found in the natural matrix that surrounds and supports cells.

Experimenting with different matrix proteins and growth factors, they were able to make pulmonary valve leaflets that had the right mechanical properties sturdy yet pliable. Tests showed the original cells had differentiated to form both endothelial cells and smooth-muscle-like cells and added to the surrounding matrix to hold them together.

With grants from the American Heart Association and the Cambridge, Mass.-based Center for Integration of Medicine and Innovative Technology (CIMIT), Sales is now refining the lab-grown valves by exposing them to mechanical stress in a bioreactor. She is also using a cardiac jelly a cushiony material rich in matrix components and growth factors to encourage cells to differentiate and form a heart valve on their own, with only minimal reliance on an artificial scaffold. I would like to mimic what really happens in the embryo what Mother Nature does, she says. The next step would be to implant the living valves into animals.

Sales and surgical research fellow Bret Mettler, MD, have already used tiny tissue-engineered patches in sheep to rebuild a portion of the pulmonary artery an area that often needs augmentation in patients with congenital heart disease. Eventually, Sales hopes to use tissue-engineering techniques to create living stents for adults with atherosclerosis.


'/>"/>

Contact: Anna Gonski
anna.gonski@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
Source:Eurekalert

Related biology news :

1. Towards precise classification of cancers based on robust gene functional expression profiles
2. Unchecked DNA replication drives earliest steps toward cancer
3. Virologists make major step towards understanding the process of HIV infection
4. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
5. Cats indifference towards sugar explained
6. A step toward the $1,000 personal genome using readily available lab equipment
7. Survey Uncovers Surprising Attitudes Towards HIV Vaccine Research
8. A new step towards an AIDS vaccine
9. New GM mosquito sexing technique is step towards malaria control, report scientists
10. Novel method reveals how menthol discovery could point towards new or improved pain therapies
11. Scientists make first step towards holy grail of crystallography
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... research firm Parks Associates announced today that Tom Kerber ... Annual Meeting , October 11 in Scottsdale, Arizona . ... how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... healthcare and technology sector at their fourth annual Conference where founders, investors, innovative ... speakers and the ELEVATE pitch competition showcasing early stage digital health and med ...
Breaking Biology Technology: