Navigation Links
A step toward better brain implants using conducting polymer nanotubes
Date:9/29/2009

ANN ARBOR, Mich.---Brain implants that can more clearly record signals from surrounding neurons in rats have been created at the University of Michigan. The findings could eventually lead to more effective treatment of neurological disorders such as Parkinson's disease and paralysis.

Neural electrodes must work for time periods ranging from hours to years. When the electrodes are implanted, the brain first reacts to the acute injury with an inflammatory response. Then the brain settles into a wound-healing, or chronic, response.

It's during this secondary response that brain tissue starts to encapsulate the electrode, cutting it off from communication with surrounding neurons.

The new brain implants developed at U-M are coated with nanotubes made of poly(3,4-ethylenedioxythiophene) (PEDOT), a biocompatible and electrically conductive polymer that has been shown to record neural signals better than conventional metal electrodes.

U-M researchers found that PEDOT nanotubes enhanced high-quality unit activity (signal-to-noise ratio >4) about 30 percent more than the uncoated sites. They also found that based on in vivo impedance data, PEDOT nanotubes might be used as a novel method for biosensing to indicate the transition between acute and chronic responses in brain tissue.

The results are featured in the cover article of the Oct. 5 issue of the journal Advanced Materials. The paper is titled, "Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly(3-4-ethylenedioxythiophene) Nanotubes."

"Microelectrodes implanted in the brain are increasingly being used to treat neurological disorders," said Mohammad Reza Abidian, a post-doctoral researcher working with Professor Daryl Kipke in the Neural Engineering Laboratory at the U-M Department of Biomedical Engineering.

"Moreover, these electrodes enable neuroprosthetic devices, which hold the promise to return functionality to individuals with spinal cord injuries and neurodegenerative diseases. However, robust and reliable chronic application of neural electrodes remains a challenge."

In the experiment, the researchers implanted two neural microelectrodes in the brains of three rats. PEDOT nanotubes were fabricated on the surface of every other recording site by using a nanofiber templating method. Over the course of seven weeks, researchers monitored the electrical impedance of the recording sites and measured the quality of recording signals.

PEDOT nanotubes in the coating enable the electrodes to operate with less electrical resistance than current metal electrode sites, which means they can communicate more clearly with individual neurons.

"Conducting polymers are biocompatible and have both electronic and ionic conductivity," Abidian said. "Therefore, these materials are good candidates for biomedical applications such as neural interfaces, biosensors and drug delivery systems."

In the experiments, the Michigan researchers applied PEDOT nanotubes to microelectrodes provided by the U-M Center for Neural Communication Technology. The PEDOT nanotube coatings were developed in the laboratory of David C. Martin, now an adjunct professor of materials science and engineering, macromolecular science and engineering, and biomedical engineering. Martin is currently the Karl W. Ber Professor and Chair of the Materials Science and Engineering Department at the University of Delaware.

Martin is also co-founder and chief scientific officer for Biotectix, a U-M spinoff company located in Ann Arbor. The company is working to commercialize conducting polymer-based coatings for a variety of biomedical devices

In previous experiments, Abidian and his colleagues have shown that PEDOT nanotubes could carry with them drugs to prevent encapsulation.

"This study paves the way for smart recording electrodes that can deliver drugs to alleviate the immune response of encapsulation," Abidian said.


'/>"/>

Contact: Byron Roberts
byronr@umich.edu
734-647-7085
University of Michigan
Source:Eurekalert  

Related biology news :

1. Toward a nanomedicine for brain cancer
2. Rats move toward the food but do not eat
3. Scientists take early steps toward mapping epigenetic variability
4. Toward an explanation for Crohns disease?
5. Gene expression findings a step toward better classification and treatment of juvenile arthritis
6. Toward cheap underwater sensor nets
7. Activated stem cells in damaged lungs could be first step toward cancer
8. Progress toward artificial tissue?
9. Toward a systems biology map of iron metabolism
10. Towards a natural pacemaker
11. Optimum running speed is stride toward understanding human body form
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A step toward better brain implants using conducting polymer nanotubes
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Tampa Bay, Florida (PRWEB) , ... October 11, ... ... Food and Drug Administration (FDA) has granted orphan drug designation to SBT-100, its ... antibody (sdAb) for the treatment of osteosarcoma. SBT-100 is able to cross the ...
(Date:10/10/2017)... Poway, California (PRWEB) , ... October 10, 2017 , ... ... afternoon speaking at his local San Diego Rotary Club. The event ... San Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
(Date:10/9/2017)... ... 2017 , ... The Giving Tree Wellness Center announces the ... of consumers who are incorporating medical marijuana into their wellness and health regimens. ... operators of two successful Valley dispensaries, The Giving Tree’s two founders, Lilach Mazor ...
Breaking Biology Technology: