Navigation Links
A step forward in virology
Date:4/24/2008

The vaccinia virus has a problem: it is a giant among viruses and needs a special strategy in order to infiltrate a cell and reproduce. Professor Ari Helenius and Postdoc Jason Mercer from ETH Zurichs Institute for Biochemistry have now discovered what this strategy is. In the process, they stumbled upon new and surprising findings.

The invasion strategy

In order to infiltrate a cell, the vaccinia virus exploits the cellular waste disposal mechanism. When a cell dies, other cells in the vicinity ingest the remains, without needing waste disposal experts such as macrophages. The cells recognize the waste via a special molecule, phosphatidylserine, which sits on the inner surface of the double membrane of cells. This special molecule is pushed out as soon as the cell dies and is broken into parts. The vaccinia virus itself also car-ries this official waste tag on its surface. The substance accumulates on the shell of vaccinia viruses, Jason Mercer explained. The pathogen disguises itself as waste material and tricks cells into digesting it, just as they normally would with the remains of dead cells. As the immune response is simultaneously sup-pressed, the virus can be ingested as waste without being noticed.

The uptake into the cell itself is via macropinocytosis. The ETH Zurich researchers have demonstrated that the vaccinia virus moves along actin-rich filamentous extensions towards the cell. As soon as they impinge upon the cell membrane, an evagination forms, a bleb. The virus itself is the trigger for the formation of the evagination. Using a messenger substance to knock on the door, the virus triggers a signaling chain reaction inside the cell so that the bleb forms, catches the virus and smuggles it into the cell.

Proteins as unsuspecting allies

The viruses are the Trojan horses that want to enter Troy; the Trojans are the many proteins that transmit the signals and open the city gate
'/>"/>

Contact: Jason Mercer
jason.mercer@bc.biol.ethz.ch
41-044-632-5818
ETH Zurich/Swiss Federal Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Is hybridoma production about to take a quantum leap forward?
2. Graduate Education in Physics: Which Way Forward?
3. Karen Beemon wins the 2007 Retrovirology Prize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... ANN ARBOR Because the strong currents in the ... rupture of the oil pipeline beneath the channel would ... and Huron, according to a new University of Michigan ... one scenario examined in the study and accompanying animations, ... and Round Island after 12 hours and Bois Blanc ...
(Date:7/10/2014)... Anoplolepis gracilipes is ranked amongst the top 100 worst ... on islands. A new study published in the open access ... effects and dangers of the introduction of the yellow crazy ... of the Valle de Mai, a UNESCO World Heritage Site, ... Mai is a unique ecosystem containing many endemic species, including ...
(Date:7/10/2014)... YORK, NY (July 10, 2014) Columbia University Medical ... personalized gene therapies for patients with retinitis pigmentosa (RP), ... first of its kind, takes advantage of induced pluripotent ... retinal cells, which are then used as a patient-specific ... this approach, researchers led by Stephen H. Tsang, MD, ...
Breaking Biology News(10 mins):Straits of Mackinac 'worst possible place' for a Great Lakes oil spill 2Straits of Mackinac 'worst possible place' for a Great Lakes oil spill 3Invasion of yellow crazy ant in a Seychelles UNESCO palm forest: Threats and solutions 2Patient-specific stem cells and personalized gene therapy 2Patient-specific stem cells and personalized gene therapy 3
... the world, nitrogen compounds are released to the ... fuels. These pollutants are deposited to ecosystems as ... miles downwind of their release point. The Catskill ... in pointthough they contain little in the way ...
... BIRMINGHAM, Ala. The newest generation of compact research ... boosted the scientific capacity of the International Space Station ... Birmingham (UAB). A UAB-designed cryogenic freezer called GLACIER, ... made its NASA debut in late 2008 aboard a ...
... DC Fascinating scientific advances across the spectrum ... be featured and explained through engaging table-top exhibits ... 15th Annual Exhibition & Reception. The exhibition/reception will ... March 24, in Rooms B338-340 of the Rayburn ...
Cached Biology News:Tree species composition influences nitrogen loss from forests 2Science returns to the Capitol Hill spotlight at March 24 exhibition 2Science returns to the Capitol Hill spotlight at March 24 exhibition 3Science returns to the Capitol Hill spotlight at March 24 exhibition 4
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2
... show of ... supporters, gains momentum, PITTSBURGH, July ... future, finding an advantage amidst global,competition requires finding new and ... does just,that, and will help secure that edge., The ...
... /Xinhua-PRNewswire/ -- Over 300 of,China,s top stem cell ... latest results and held China,s first ever symposium ... the just,concluded first annual 2008 China Stem Cell ... Taizhou, China. At the Forum, which was chaired ...
... Geoffrey Allan Will Discuss Company,s IPLEX(TM) Program in Myotonic ... ... Inc. (Nasdaq:,INSM) a developer of follow-on biologics and biopharmaceuticals, today,announced that ... Drug Discovery and Development of Innovative Therapeutics on,Thursday, August 7th, 2008 ...
Cached Biology Technology:Conference to Turn Scientists of Color into PA-Based Entrepreneurs Set for November 2Conference to Turn Scientists of Color into PA-Based Entrepreneurs Set for November 3Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells 2Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells 3Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells 4Insmed CEO to Present at Drug Discovery & Development Conference 2
Homo sapiens jumping translocation breakpoint...
RABBIT ANTI HUMAN TRRAP (CT) Immunogen: Recombinant C-terminal kinase-related domain of human TRRAP....
Edited by D. Rickwood, T.C. Ford and J.T. Steensgaard (1994) Compiles core data required by researchers carrying out any centrifugal separation, whether working with cells, organelles or macromolec...
MOUSE ANTI PROTEIN KINASE C BETA 2 Immunogen: Protein kinase C beta 2...
Biology Products: