Navigation Links
A stem cell secreted protein can be given to improve heart function after experimental heart attack
Date:11/17/2010

DURHAM, N.C. -- Heart tissue and stem cells spring into action to begin repairing muscle damaged in a heart attack, and researchers at Duke University School of Medicine found that a protein naturally produced in the body may potentially play a role in accelerating heart muscle repair. Giving the right dose of this protein named secreted frizzled related protein 2 (sfrp2) in studies of rats helped to prevent heart failure and reduce collagen layering that can form thick scar tissue after a heart attack (also called MI, or myocardial infarction). Previously the same researchers demonstrated that this protein also saves heart muscle cells from dying in response to heart attack.

These findings have the potential to be translated into a new therapy for study and evaluation in human clinical trials, said Victor Dzau, M.D., senior author of the study and James B Duke Professor of Medicine.

"We found that giving the study rats the protein sfrp2 strongly improved heart function in the critical pumping chamber, the left ventricle, after a myocardial infarction," Dr. Dzau said. "We observed that sfrp2 at therapeutic doses reduced heart muscle death and also directly prevented deposits of collagen, and thus reduced the scarring that can affect heart function."

The study was published the week of Nov. 15 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition online.

Giving sfrp2 also helped prevent the heart wall from thinning, by the fourth week after injection. Because the scarring process (fibrosis) and tissue remodeling in the heart are often complete within a month of a heart attack in rats, the team performed a heart test called echocardiography (heart ultrasound) on the rats at three and four weeks after the myocardial infarction.

"We found the sfrp2 reduced the area of fibrosis in the left ventricle and also significantly decreased the ratio of anterior-to-posterior wall thickness in the heart
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Structure of a protein related to heart and nervous system health revealed
2. Synapses recycle proteins for the release of neurotransmitters
3. Prima donna protein doesnt work well in pairs
4. Scientists at IRB Barcelona discover a new protein critical for mitochondria
5. X-ray crystallography reveals structure of precursor to blood-clotting protein
6. Chemists concoct new agents to easily study critical cell proteins
7. Scripps Research team watches formation of cells protein factories for first time
8. Rictor protein offers scientists a new molecular target for cancer therapies
9. Structural genomics accelerates protein structure determination
10. Too much SP2 protein turns stem cells into evil twin cancer cells
11. Elsevier introduces Protein Viewer, bringing science to life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... ST. PAUL, Minn. , Dec. 10, 2014 ... in wireless physiologic monitoring, has released a new ... changing needs of preclinical toxicology researchers. M series, ... to help toxicologists collect the best possible physiologic ... studies. Adding functional endpoints to toxicology ...
(Date:12/10/2014)... Forest Baptist Medical Center today announced plans for a ... Funding for this $50 million capital project is part ... launched next summer. The medical education ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in ... plans to be ready to welcome medical students in ...
(Date:12/10/2014)... , December 9, 2014 ... BCARD Platform   ... meeting scheduling solutions for business-to-business (B2B) events, today ... leader in mobile near-field communication (NFC), Bluetooth low ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... AMSTERDAM , April 27, 2010 ... in heightened focus on credit risk,management throughout Europe ... marginal improvement in payment behaviour of domestic,and foreign buyers ... may,reflect the response to tighter, more diligent credit management ...
... LONDON , April 27, 2010 Dominio ... partner for the .CO domain name launch. , ... Julio Camacho , CEO, Dominio Amigo ... years they have consistently performed,at both ccTLD and gTLD launches, securing the very ...
... JINZHOU CITY, China , April 27 /PRNewswire-Asia/ -- Wonder ... supplier of,automotive electric parts, suspension products and engine components in China ,wins ... of,its subsidiaries, which is Jinzhou Wanyou Mechanical Parts Co., Ltd ("Wanyou"). , ... On 23 April, Wanyou ...
Cached Biology News:Payment Default Risks Remain a Crucial Issue for Businesses Across Europe 2Payment Default Risks Remain a Crucial Issue for Businesses Across Europe 3Payment Default Risks Remain a Crucial Issue for Businesses Across Europe 4Dominio Amigo Announce Domainmonster as .CO Technical Partner 2Dominio Amigo Announce Domainmonster as .CO Technical Partner 3Wonder Auto Obtains a New World-class Customer in Germany 2Wonder Auto Obtains a New World-class Customer in Germany 3
(Date:12/19/2014)... , Dec. 18, 2014 Relmada Therapeutics, ... for the treatment of chronic pain, announced the results ... "This was a transformational year in Relmada,s ... future for our company," said Sergio Traversa , ... we have executed on key financial, human resource and ...
(Date:12/17/2014)... Achim Noack has been named global vice president ... position, Noack will assist Jerry Stoller, CEO and president ... and supervise global marketing management and implementation of new ... and experience in the crop protection industry,” says Jerry ... thinking will be a great asset for Stoller Group, ...
(Date:12/17/2014)... December 17, 2014 Xeno Diagnostics ... following its most recent COLA inspection. Xeno has ... a national healthcare accreditation organization. Accreditation is earned ... quality in day-to-day operations, demonstrate continued accuracy in ... rigorous on-site laboratory survey. , While ...
(Date:12/17/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) ... changes to Martine Rothblatt , Ph.D,s compensation program. ... United Therapeutics announced the promotion of Roger Jeffs ... David Zaccardelli , Pharm.D. to Executive Vice President ... Dr. Rothblatt,s title will change from Chairman and Chief ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... April 11, 2012 UBM Canon,s Medical Design ... for medical device design and innovation, has announced that ... Achievement Award to Dr. Thomas Fogarty during the ... (Photo: http://photos.prnewswire.com/prnh/20120411/LA84898 ) (Logo: ...
... CAYMAN, Cayman Islands, April 10, 2012 Narayana ... partnership with Ascension Health Alliance of the United ... Cayman Islands. Narayana Hrudayalaya Hospitals (NH) ... Devi Prasad Shetty, a world-renowned cardiovascular surgeon with ...
... MILFORD, Mass., April 10, 2012  Psyche Systems Corporation ... Healthcare, Malvern, Pa., under which WindoPath®, Psyche,s award ... the anatomic pathology component of NOVIUS® Lab, Siemens ... provides an enterprise-wide workflow solution that is built ...
Cached Biology Technology:UBM Canon, the Global MedTech Authority, and the Medical Design Excellence Awards Announce Dean Kamen as the Presenter of the 2012 Lifetime Achievement Award 2UBM Canon, the Global MedTech Authority, and the Medical Design Excellence Awards Announce Dean Kamen as the Presenter of the 2012 Lifetime Achievement Award 3Narayana Hrudayalaya Hospitals Teams With Ascension Health Alliance to Build Health City at Grand Cayman 2Narayana Hrudayalaya Hospitals Teams With Ascension Health Alliance to Build Health City at Grand Cayman 3Narayana Hrudayalaya Hospitals Teams With Ascension Health Alliance to Build Health City at Grand Cayman 4Psyche Systems Corporation Signs Strategic Alliance with Siemens Healthcare to Provide Anatomic Pathology Solutions 2
Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human GFR alpha-4 Affinity Purified Polyclonal Ab...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
Human Siglec-9 Biotinylated Affinity Purified Pab...
Biology Products: