Navigation Links
A stem cell secreted protein can be given to improve heart function after experimental heart attack
Date:11/17/2010

DURHAM, N.C. -- Heart tissue and stem cells spring into action to begin repairing muscle damaged in a heart attack, and researchers at Duke University School of Medicine found that a protein naturally produced in the body may potentially play a role in accelerating heart muscle repair. Giving the right dose of this protein named secreted frizzled related protein 2 (sfrp2) in studies of rats helped to prevent heart failure and reduce collagen layering that can form thick scar tissue after a heart attack (also called MI, or myocardial infarction). Previously the same researchers demonstrated that this protein also saves heart muscle cells from dying in response to heart attack.

These findings have the potential to be translated into a new therapy for study and evaluation in human clinical trials, said Victor Dzau, M.D., senior author of the study and James B Duke Professor of Medicine.

"We found that giving the study rats the protein sfrp2 strongly improved heart function in the critical pumping chamber, the left ventricle, after a myocardial infarction," Dr. Dzau said. "We observed that sfrp2 at therapeutic doses reduced heart muscle death and also directly prevented deposits of collagen, and thus reduced the scarring that can affect heart function."

The study was published the week of Nov. 15 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition online.

Giving sfrp2 also helped prevent the heart wall from thinning, by the fourth week after injection. Because the scarring process (fibrosis) and tissue remodeling in the heart are often complete within a month of a heart attack in rats, the team performed a heart test called echocardiography (heart ultrasound) on the rats at three and four weeks after the myocardial infarction.

"We found the sfrp2 reduced the area of fibrosis in the left ventricle and also significantly decreased the ratio of anterior-to-posterior wall thickness in the heart," said Maria Mirotsou, Ph.D., a co-author and assistant professor of medicine.

Previously, the Dzau laboratory showed that a genetically modified type of stem cell that over-produced a factor called Akt dramatically reduced the size of the area affected by a heart attack and restored cardiac function in rodent hearts. The team identified sfrp2 as a key factor released by these stem cells during heart tissue survival and repair, and this study showed sfrp2 was a likely candidate for inhibiting collagen production, as well.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. Structure of a protein related to heart and nervous system health revealed
2. Synapses recycle proteins for the release of neurotransmitters
3. Prima donna protein doesnt work well in pairs
4. Scientists at IRB Barcelona discover a new protein critical for mitochondria
5. X-ray crystallography reveals structure of precursor to blood-clotting protein
6. Chemists concoct new agents to easily study critical cell proteins
7. Scripps Research team watches formation of cells protein factories for first time
8. Rictor protein offers scientists a new molecular target for cancer therapies
9. Structural genomics accelerates protein structure determination
10. Too much SP2 protein turns stem cells into evil twin cancer cells
11. Elsevier introduces Protein Viewer, bringing science to life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... 25, 2016 , ... Lajollacooks4u has become a rising hotspot for specialized team ... its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm and Elsevier, ... team-building experience. , Each event kicks off with an olive oil and salt-tasting competition. ...
(Date:5/25/2016)... ... May 25, 2016 , ... Scientists at the University ... being tried for mesothelioma may be hampering the research that could lead to one ... Click here to read it now. , The team evaluated 98 mesothelioma ...
(Date:5/24/2016)... --  MedyMatch Technology Ltd ., the data analytics healthcare company ... tools in the emergency room, announced today that it has ... Industries (IATI) BioMed Conference. The Conference is ... Life Sciences and Technology Week, and is being held May ... Tel Aviv, Israel . Gene Saragnese , ...
(Date:5/23/2016)... , May 23, 2016 Zimmer Biomet Holdings, ... healthcare, today announced that its Board of Directors has approved ... the second quarter of 2016. The cash ... about July 29, 2016 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
Breaking Biology Technology: