Navigation Links
'A stark warning:' Smoking causes genetic damage within minutes after inhaling
Date:1/15/2011

WASHINGTON, Jan. 15, 2011 In research described as "a stark warning" to those tempted to start smoking, scientists are reporting that cigarette smoke begins to cause genetic damage within minutes not years after inhalation into the lungs.

Their report, the first human study to detail the way certain substances in tobacco cause DNA damage linked to cancer, appears in Chemical Research in Toxicology, one of 38 peer-reviewed scientific journals published by the American Chemical Society.

Stephen S. Hecht, Ph.D., and colleagues point out in the report that lung cancer claims a global toll of 3,000 lives each day, largely as a result of cigarette smoking. Smoking also is linked to at least 18 other types of cancer. Evidence indicates that harmful substances in tobacco smoke termed polycyclic aromatic hydrocarbons, or PAHs, are one of the culprits in causing lung cancer. Until now, however, scientists had not detailed the specific way in which the PAHs in cigarette smoke cause DNA damage in humans.

The scientists added a labeled PAH, phenanthrene, to cigarettes and tracked its fate in 12 volunteers who smoked the cigarettes. They found that phenanthrene quickly forms a toxic substance in the blood known to trash DNA, causing mutations that can cause cancer. The smokers developed maximum levels of the substance in a time frame that surprised even the researchers: Just 15-30 minutes after the volunteers finished smoking. Researchers said the effect is so fast that it's equivalent to injecting the substance directly into the bloodstream.

"This study is unique," writes Hecht, an internationally recognized expert on cancer-causing substances found in cigarette smoke and smokeless tobacco. "It is the first to investigate human metabolism of a PAH specifically delivered by inhalation in cigarette smoke, without interference by other sources of exposure such as air pollution or the diet. The results reported here should serve as a stark warning to those who are considering starting to smoke cigarettes," the article notes.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related biology news :

1. Dr. George Stark receives 2011 Herbert Tabor/Journal of Biological Chemistry Lectureship from ASBMB
2. School attendance, refusal skills combat smoking risk in youth
3. Study reveals cancer-linked epigenetic effects of smoking
4. Smoking during pregnancy may harm the childs motor control and coordination
5. Personalized approach to smoking cessation may be reality in 3-5 years
6. MSU researchers testing vaccine to help people quit smoking
7. Gene fusions may be the smoking gun in prostate cancer development, U-M study finds
8. Children living in apartments with nonsmoking adults still exposed
9. Smoking during radiation therapy for head and neck cancers linked to poorer outcomes
10. GUMC to develop smoking cessation aids based on unconventional nicotine addiction theory
11. Obesity and passive smoking reduce oxygen supply to unborn baby
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:3/30/2017)... , March 30, 2017 The research ... system for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D ... a new realm of speed and accuracy for use in identification, ... an affordable cost. ... ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... NEWTOWN SQUARE, Pa. , June 20, 2017 /PRNewswire/ ... technology, is pleased to announce the issuance of a ... treating gout or hyperuricemia by the U.S. Patent and ... Biotech Inc., a winner of the Buzz of Bio ... , is akin to developing non-drug approaches to ...
(Date:6/19/2017)... ... June 19, 2017 , ... EDETEK, ... reported today that it is launching two new additions of its award-winning cloud-based ... new capabilities at the DIA 2017 Annual Meeting in Chicago, IL, June 19-22, ...
(Date:6/16/2017)... ... June 16, 2017 , ... CTNext , Connecticut’s ... Awards (EIA), held at The LOFT at Chelsea Piers in Stamford. , Nine finalists, ... a panel of judges for an opportunity to secure $10,000 awards to help support ...
(Date:6/15/2017)... ... June 15, 2017 , ... DuPont ... Biofuels, will be speaking at Bloomberg’s 2017 Sustainable Business Summit: Seattle ... environmental and sustainability officials on a panel titled “Developing a Corporate Renewables Strategy.” ...
Breaking Biology Technology: