Navigation Links
A smart use for wisdom teeth: Making stem cells
Date:9/10/2010

For most people, wisdom teeth are not much more than an annoyance that eventually needs to be removed. However, a new study appearing in the September 17 Journal of Biological Chemistry shows that wisdom teeth contain a valuable reservoir of tissue for the creation of stem cells; thus, everyone might be carrying around his or her own personal stem-cell repository should he or she ever need some.

Groundbreaking research back in 2006 revealed that inducing the activity of four genes in adult cells could "reprogram" them back into a stem-cell-like state; biologically, these induced-pluripotent stem cells are virtually identical to embryonic stem cells, opening up a new potential avenue for stem-cell therapy whereby patients could be treated with their own stem cells.

However, despite their promise, making iPS cells is not easy; the reprogramming efficiencies are very low and vary among the cells that can be used for iPS generation and thus require good amount of "starter" cells - which might involve difficult extraction from body tissue (unfortunately skin cells, the easiest to acquire, show very low reprogramming efficiency).

Now, a team of scientists at Japan's National Institute of Advanced Industrial Science and Technology may have found an ideal source: third molars, commonly known as wisdom teeth.

The soft pulp inside of teeth contains a population of cells known as mesenchymal stromal cells that are similar to cells found in bone marrow, a common stem-cell source. However, unlike bone marrow, tooth pulp is more easily obtained, especially in wisdom teeth, which most individuals have removed anyway.

The researchers, led by Hajime Ohgushi, collected tooth samples from three donors and managed to generate a series of iPS cell lines following the similar procedure of activating three key genes (however, in another beneficial change they did not have activate the c-MYC gene which might lead the cells to become cancerous).

The different cell lines displayed varying degrees of robustness but in some cases proliferated quite well, up to 100 times more efficiently than typical skin-cell-derived iPS cells. The molar-derived cells also could differentiate into many other cell types including beating cardiomyocytes (see an attached movie), as expected.

The presence of a supply of MSCs in wisdom teeth could have meaningful therapeutic ramifications. As noted by the researchers and others, wisdom tooth extraction is a common medical procedure in developed nations and, thus, creates a perfect opportunity to remove biological material in a sterilized setting; the teeth subsequently can be frozen and stored for many years until needed. In the meantime, that also provides time for researchers to better understand the details of iPS creation to further increase the efficiency for clinical use.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. Full-Featured Video Analytics Platform Available in Smart Camera Format
2. JDRF to provide $1M in funding to SmartCells, Inc.
3. Bee smart, bee healthy
4. e-Smart Technologies to Introduce Next Generation I AM Smart Card Technology at Cartes 2008 in Paris
5. Brandeis and Smart Balance team up to advance heart-healthy research
6. WCC Smart Search and Match Names Rudie Lion - Product Marketing Manager
7. WCC Announces Version 6 of its ELISE Smart Search and Match Platform for Employment and Biometric Matching
8. New smart materials for the brain
9. WCC Smart Search and Match Names Rudie Lion - Product Marketing Manager
10. WCC Smart Search & Match Names Tarvinder Sembhi as VP Sales for the ID Market
11. Smart scaffolds may help heal broken hearts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2016)... -- ABI Research, the leader in transformative technology ... will reach more than $30 billion by 2021, ... electronics, particularly smartphones, continue to boost the biometrics ... two billion shipments by 2021 at a 40% ... Analyst at ABI Research. "Surveillance is also gearing ...
(Date:3/15/2016)... , March 15, 2016 Yissum Research ... the technology-transfer company of the Hebrew University, announced today ... remote sensing technology of various human biological indicators. Neteera ... $2.0 million from private investors. ... on the detection of electromagnetic emissions from sweat ducts, ...
(Date:3/14/2016)... 2016 http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ... --> DERMALOG, le leader de ... lecteurs d,empreintes digitales pour l,enregistrement des réfugiés en ... pour produire des cartes d,identité aux réfugiés. DERMALOG ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... There is no saying when ... relentless pressures in pricing and lack in consumer confidence. ... though - numerous opportunities are up for grabs but ... presents four names in this sector: Portola Pharmaceuticals Inc. ... VTAE ), Anthera Pharmaceuticals Inc. (NASDAQ: ...
(Date:5/18/2016)... ... 2016 , ... Shimadzu Scientific Instruments announces its sponsorship of ... two-day camp will take place annually starting June 2016. It will provide qualifying ... preparation for a university academic program. , The laboratory- and technology-focused camp ...
(Date:5/18/2016)... Kansas (PRWEB) , ... May 18, 2016 , ... Ryan ... given a life expectancy in the late teens to early twenties. DMD is a ... In 2009, at the age of 22, Benton’s condition was critical. He met with ...
(Date:5/17/2016)... New York, NY (PRWEB) , ... May 17, 2016 , ... ... Awareness Month, buildings, bridges, and monuments across the globe will show their support in ... of NF. , Neurofibromatosis, NF, is a genetic disorder that causes tumors to ...
Breaking Biology Technology: