Navigation Links
A small cut with a big impact
Date:5/2/2012

Diseases and injuries trigger warning signals in our cells. As a result, genes are expressed and proteins produced, modified or degraded to adapt to the external danger and to protect the organism. In order to be able to produce a particular protein, the corresponding DNA segment, the gene, needs to be expressed and translated. The DNA is localized in the cell nucleus, and exists as a long string that is coiled and bound by proteins. ARTD1 is one such protein, and therefore has the potential to regulate the expression level of genes through its interaction with DNA.

If cells detect warning signals or foreign bodies like bacteria and viruses in their surroundings, the expression profile of genes changes and an inflammatory response is triggered. To induce changes in gene expression, ARTD1 is removed from particular sites of the DNA. The process by which this is brought about has, until now, remained elusive. The team headed by Professor Michael O. Hottiger from the Institute of Veterinary Biochemistry and Molecular Biology at the University of Zurich has now discovered how ARTD1's DNA recruitment is regulated during inflammation, thereby influencing gene expression and subsequently inflammation.

Molecular scissors

As the researchers demonstrate in Molecular Cell, ARTD1 is cut into two pieces by molecular scissors, the protein caspase 7. Upon cleavage, these pieces can no longer bind to the DNA, thus allowing for more efficient gene expression.

The cleavage of proteins by caspase 7 was so far mainly associated with cell death. "The cleavage of ARTD1 by caspase 7 during inflammation constitutes a new biological function. It permits a new understanding of inflammatory responses and, in the longer term, may lead to the development of new anti-inflammatory drugs," explains Professor Hottiger. The results are of considerable importance because inflammation underlies most diseases, including cancer, immune disorders or metabolic syndrome.


'/>"/>

Contact: Michael Hottiger
hottiger@vetbio.uzh.ch
41-446-355-477
University of Zurich
Source:Eurekalert

Related biology news :

1. Laparoscopy reduces the risk of small-bowel obstruction
2. New analysis helps guide use of erlotinib in advanced non-small cell lung cancer
3. Turning off small RNA
4. Smallest tools could give biggest results in bone repair
5. New species of tiny frog is worlds smallest vertebrate
6. Members of small monkey groups more likely to fight
7. A small step for lungfish, a big step for the evolution of walking
8. Worlds smallest frogs discovered in New Guinea
9. Big pest, small genome
10. Scripps research scientists develop brand new class of small molecules through innovative chemistry
11. CO2 bonds in sea ice: Small living creatures with major impact
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
(Date:1/21/2016)... 21, 2016 --> ... market research report "Emotion Detection and Recognition Market by Technology ... (Facial Expression, Voice Recognition and Others), Services, Application ... to 2020", published by MarketsandMarkets, the global Emotion ... USD 22.65 Billion by 2020, at a CAGR ...
(Date:1/20/2016)... 20, 2016  Synaptics Incorporated (NASDAQ: SYNA ... today announced sampling of S1423, its newest ClearPad ... small screen applications including smartwatches, fitness trackers, and ... and rectangular shapes, as well as thick and ... moisture on screen, while wearing gloves, and supports ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare Medical, LLC reports the ... Sonalink™ remote monitoring. The inaugural launch of this new technology occurred over the ... Samuel Peretsman to a HIFU technical expert at SonaCare Medical headquarters. , ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... now available on Microsoft Azure. On Azure, Arvados provides capabilities for managing and ... clear demand for Microsoft Azure from major institutions collecting and analyzing genomic data,” ...
(Date:2/10/2016)... ... ... Cenna Bioscience Inc., an emerging biopharmaceutical company focused on the discovery and ... been selected to present at the Cavendish Global Health Impact Forum taking place February ... of the Forum is to help family offices and foundations develop and implement their ...
(Date:2/9/2016)... ... ... With a presidential election in November and the future of U.S. healthcare in ... top healthcare leaders for a night and day of debates and discussions about what ... the University of Pennsylvania’s Wharton School, will be held February 18 – 19, 2016 ...
Breaking Biology Technology: