Navigation Links
A small cut with a big impact
Date:5/2/2012

Diseases and injuries trigger warning signals in our cells. As a result, genes are expressed and proteins produced, modified or degraded to adapt to the external danger and to protect the organism. In order to be able to produce a particular protein, the corresponding DNA segment, the gene, needs to be expressed and translated. The DNA is localized in the cell nucleus, and exists as a long string that is coiled and bound by proteins. ARTD1 is one such protein, and therefore has the potential to regulate the expression level of genes through its interaction with DNA.

If cells detect warning signals or foreign bodies like bacteria and viruses in their surroundings, the expression profile of genes changes and an inflammatory response is triggered. To induce changes in gene expression, ARTD1 is removed from particular sites of the DNA. The process by which this is brought about has, until now, remained elusive. The team headed by Professor Michael O. Hottiger from the Institute of Veterinary Biochemistry and Molecular Biology at the University of Zurich has now discovered how ARTD1's DNA recruitment is regulated during inflammation, thereby influencing gene expression and subsequently inflammation.

Molecular scissors

As the researchers demonstrate in Molecular Cell, ARTD1 is cut into two pieces by molecular scissors, the protein caspase 7. Upon cleavage, these pieces can no longer bind to the DNA, thus allowing for more efficient gene expression.

The cleavage of proteins by caspase 7 was so far mainly associated with cell death. "The cleavage of ARTD1 by caspase 7 during inflammation constitutes a new biological function. It permits a new understanding of inflammatory responses and, in the longer term, may lead to the development of new anti-inflammatory drugs," explains Professor Hottiger. The results are of considerable importance because inflammation underlies most diseases, including cancer, immune disorders or metabolic syndrome.


'/>"/>

Contact: Michael Hottiger
hottiger@vetbio.uzh.ch
41-446-355-477
University of Zurich
Source:Eurekalert

Related biology news :

1. Laparoscopy reduces the risk of small-bowel obstruction
2. New analysis helps guide use of erlotinib in advanced non-small cell lung cancer
3. Turning off small RNA
4. Smallest tools could give biggest results in bone repair
5. New species of tiny frog is worlds smallest vertebrate
6. Members of small monkey groups more likely to fight
7. A small step for lungfish, a big step for the evolution of walking
8. Worlds smallest frogs discovered in New Guinea
9. Big pest, small genome
10. Scripps research scientists develop brand new class of small molecules through innovative chemistry
11. CO2 bonds in sea ice: Small living creatures with major impact
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population ... challenge of how to continue to feed a growing nation. At the same time, ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System ... standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography ...
(Date:10/7/2017)... WALTHAM, Mass. , Oct. 6, 2017 /PRNewswire/ ... pioneering work of three scientists, Jacques Dubochet, ... whose breakthrough developments in cryo-electron microscopy ... this technology within the structural biology community. The ... Scientific. Scientists can now routinely produce highly resolved, ...
(Date:10/5/2017)... (PRWEB) , ... October 05, 2017 , ... LabRoots ... and scientists from around the world, is giving back to cancer research with a ... October. , Now through October 31, shoppers can use promo code PinkRibbon to ...
Breaking Biology Technology: