Navigation Links
A sip of resveratrol and a full p53: Ingredients for a successful cell death
Date:11/13/2012

a group led by Dr Jerson L. Silva at the Universidade Federal do Rio de Janeiro, Brazil, tested the effects of resveratrol in H1299, a human non-small lung carcinoma cell line carrying only a partial fragment of the p53 gene and compared the results with MCF-7, A549, and H460, which are cancer cell lines carrying normal copies of p53. The study shows that although resveratrol affects the viability of all cancer cell lines, MCF-7, A549, and H460 are more sensitive to the effects of resveratrol than H1299. While MCF-7 cell lines die after exposure to resveratrol, H1299 remains resistant. Additional findings indicate that the toxic effect of resveratrol on MCF-7, A549, and H460 cell lines is mediated by p53.

The research group then went one step further and asked what would happen if a normal copy of p53 is added to the previously p53-defective H1299 cancer cell line. The results, published this week in PLOS ONE, show that introduction of a normal copy of p53 in H1299 turns the cell line sensitive to the anti-tumor effects of resveratrol, similarly to that observed in other cancer cell lines (MCF-7, A549, and H460). "Our findings may have potential applications in cancer cell lines that are under p53 control," says Dr Danielly Ferraz da Costa, the first author of the study. "Also, the introduction of the p53 gene in p53-defective tumors, followed by resveratrol treatment, may represent a novel and promising therapeutic approach in our fight against cancer," says the young author.


'/>"/>

Contact: Jerson Lima Silva
jerson@bioqmed.ufrj.br
55-212-562-6756
Publicase Comunicao Cientfica
Source:Eurekalert

Page: 1 2

Related biology news :

1. Resveratrol may be a natural exercise performance enhancer: U of A medical research
2. The effect of catch-up growth by various diets and resveratrol intervention on bone status
3. New oil spill dispersant made from ingredients in peanut butter, chocolate, ice cream
4. Chinese scientists successfully crack the genome of diploid cotton
5. First paternity study of southern right whales finds local fathers most successful
6. Successful stem cell differentiation requires DNA compaction, study finds
7. Chronic kidney disease increases risk of death at all ages
8. Mount Sinai researchers solve mystery surrounding the death of two sisters nearly 50 years ago
9. Allergies? Your sneeze is a biological response to the noses blue screen of death
10. Sickle cell trait can cause sudden cardiac death in black athletes: Why is this controversial?
11. Lace plants explain programmed cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... AWRE ), a leading technology innovator and supplier ... call to discuss the company,s operating results for the third ... Eastern Time. President and CEO Edmund Reiter and CFO Rick ... call is being webcast by Thomson and can be accessed ...
... slice it, watermelon has a lot going for it ... there,s more. Evidence from a pilot study led by food ... be an effective natural weapon against prehypertension, a precursor to ... its kind in humans. FSU Assistant Professor Arturo Figueroa and ...
... ,URBANA When you think about "wine country," Illinois may not ... big business on the prairie. There are 90 wineries licensed in ... wine grapes can bring as much as $8,000 in sales, though ... produce 90,000 gallons per year, while many produce 3,000 to 10,000 ...
Cached Biology News:Aware, Inc. Announces Q3'10 Earnings Conference Call 2Florida State study finds watermelon lowers blood pressure 2Florida State study finds watermelon lowers blood pressure 3Taming wild grapes for better wine 2Taming wild grapes for better wine 3
(Date:5/20/2015)... 2015  Select Medical Corporation ("Select") (NYSE: ... granted early termination of the waiting period under ... as amended, applicable to the acquisition of Concentra ... venture that Select has created with Welsh, Carson, ... announced, MJ Acquisition Corporation has signed a definitive ...
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., ... of Tiger-Sul. Since the purchase of Tiger Industries ... May 2005, H.J. Baker has leveraged the innovation of ... comprehensive portfolio of product offerings and solutions expertise. The ... the innovation of Tiger-Sul, transforming the company into a ...
(Date:5/20/2015)... DIEGO , May 20, 2015  Cypher ... announced a collaboration with Celgene Corporation to apply ... genomic biomarkers that associate with patient response to ... is intended to help accelerate patient access to ... efficiencies in clinical research and development and potentially ...
(Date:5/20/2015)... RESEARCH TRIANGLE PARK, North Carolina ... das weltweit führende Unternehmen für klinische ... geprüften Finanzergebnisse für das Geschäftsjahr 2014, ... abgeschlossen und eingereicht. Das Unternehmen hat ... abgeschlossen. Logo - ...
Breaking Biology Technology:Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... March 27, 2012 Vermillion, Inc. (NASDAQ: ... and operational results for the fourth quarter and full ... Full Year 2011 Operational Highlights In ... diagnostic designed to help differentiate benign from malignant ovarian ...
... March 26, 2012 The L,ORÉAL-UNESCO For Women in ... a week of scientific meetings and debates. , ... International Fellows will be presenting their research at the Pasteur Institute ... at the Institute where the International Fellows can be met individually ...
... massive particles has intrigued physicists for more than 80 years, ... behaviour in conflict with our everyday ideas of what ... now succeeded in shooting a movie which shows the build-up ... is so large (up to 0.1 mm) that you can ...
Cached Biology Technology:Vermillion Reports Fourth Quarter and Full Year 2011 Results 2Vermillion Reports Fourth Quarter and Full Year 2011 Results 3Vermillion Reports Fourth Quarter and Full Year 2011 Results 4Vermillion Reports Fourth Quarter and Full Year 2011 Results 5Vermillion Reports Fourth Quarter and Full Year 2011 Results 6Vermillion Reports Fourth Quarter and Full Year 2011 Results 7Vermillion Reports Fourth Quarter and Full Year 2011 Results 8The 14th Annual L'Oréal-Unesco Awards or Women on Science: From March 26 to March 29, Paris Welcomes and Honours Tomorrow's Scientific Talents 2The 14th Annual L'Oréal-Unesco Awards or Women on Science: From March 26 to March 29, Paris Welcomes and Honours Tomorrow's Scientific Talents 3The 14th Annual L'Oréal-Unesco Awards or Women on Science: From March 26 to March 29, Paris Welcomes and Honours Tomorrow's Scientific Talents 4Single molecules in a quantum movie 2
... reliable and compact GC-8A is Shimadzu's basic ... and simple to use, the GC-8A supports ... control, on column injection port(s), and analog ... models are available. The GC-8A is only ...
... system combines world-class performance hardware, Cerity Networked ... world-renowned support and columns, as well as ... that lets you reach uncompromising results and ... data. The Agilent 6820 GC system is ...
... Adding an exciting new chapter ... GC leadership, Agilents 7890A GC ... to take your lab to ... and GC/MS performance, including advanced ...
The essence of fluorescence analysis is sensitivity. The high throughput optical system in the RF-5301PC employs a blazed holographic grating, photomultiplier and digital signal processing to provide...
Biology Products: