Navigation Links
A single mechanism for hypertension, insulin resistance and immune suppression
Date:6/29/2008

Many of the 75 million Americans with essential hypertension also develop diabetes and other complications in addition to their high blood pressure, and researchers have discovered a common molecular mechanism in a strain of rat that explains why such metabolic disorders arise together in mammals.

The bioengineering researchers at UC San Diegos Jacobs School of Engineering also showed that a drug developed for unrelated purposes in humans was effective in counteracting the underlying molecular mechanism in the spontaneously hypertensive rat (SHR), a strain predisposed to develop high blood pressure.

In a paper published June 30 in the online version of Hypertension, Frank DeLano, a research scientist at UC San Diego, and Geert Schmid-Schnbein, a professor of bioengineering, describe how they successfully reversed the SHR animals symptoms of high blood pressure, a pre-diabetes condition called insulin resistance, and immune suppression.

H. Glenn Bohlen, a professor in the Department of Cellular and Integrative Physiology at Indiana University Medical School, wrote in an accompanying editorial in Hypertension that the new study will likely be important to people suffering from obesity as well as hypertension. With the national and international emphasis on obesity and its attendant cardiovascular problems, there is a tendency to forget that essential hypertension affects about the same percentage of humans as does serious obesity and an even higher percentage of the population than does type 2 diabetes mellitus, wrote Bohlen. The elegant study by Delano and Schmid-Schnbein points to a potentially very important overlap of an insulin resistance mechanism with hypertension in the spontaneously hypertensive rat (SHR).

The SHR strain is a model for essential hypertension in humans because both the rodent and many humans with hypertension also develop a variety of other metabolic complications when high blood
'/>"/>

Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego
Source:Eurekalert  

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
2. Single-largest biodiversity survey says primary rainforest is irreplaceable
3. New technique captures chemical reactions in a single living cell at unprecedented resolution
4. Gene study supports single main migration across Bering Strait
5. Baumann lab identifies elusive telomere RNA subunit in single cell model
6. Ebola virus disarmed by excising a single gene
7. Blue-eyed humans have a single, common ancestor
8. Rice scientists make breakthrough in single-molecule sensing
9. Single-celled bacterium works 24-7
10. RevGenUK, a single-stop shop for use in functional genomics
11. Researchers observe spontaneous ratcheting of single ribosome molecules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A single mechanism for hypertension, insulin resistance and immune suppression
A single mechanism for hypertension, insulin resistance and immune suppression
(Date:8/20/2008)...YETTE, Ind. - Engineers have created a tiny motori...ity of similar devices being ,developed for appli...,compact, powerful computer hard drives. , The d...ed as a ,"nanoscale manipulator" that precisely m...also can be used in watery environments for probin...
(Date:8/20/2008)...are supposed to protect people from heart attacks....ll as biological security. , Earlier this year, a...ool demonstrated how a commercial radio transmitte...from a pacemaker ( New Scientist, 22 March, p 23)...d adjust the implanted device, but a malicious hac...
(Date:8/20/2008)...h led by Chu Chen, PhD, Associate Professor of Neu...s, provides evidence that one of the only naturall... ability to interact with the receptors originally...e component of marijuana) can help to protect brai...imer,s and Parkinson,s. Published in the August 15...
(Date:8/19/2008)...on coral reefs may increase invasion of unwanted s...ey study. These unwanted species can completely ov..., dramatically decreasing the diversity of marine ...e first time that a rapid change in the dominant b...ith man-made structures. , The findings of the ...
Breaking Biology News(10 mins):New 'nano-positioners' may have atomic-scale precision 2New 'nano-positioners' may have atomic-scale precision 3How to stop a new type of heart attack 2LSUHSC research reports new method to protect brain cells from diseases like Alzheimer's 2Shipwrecks on coral reefs harbor unwanted species 2Teaching old drugs new tricks 6505 1Teaching old drugs new tricks 6505 21 3 of reef building corals face extinction 3994 11 3 of reef building corals face extinction 3994 21 3 of reef building corals face extinction 3994 31 3 of reef building corals face extinction 3994 4Detecting smallest contaminations on semiconductors with aid of synchrotron radiation 6503 1American Life League Applauds Congressional Action Against Planned Parenthood 23774 1American Life League Applauds Congressional Action Against Planned Parenthood 23774 2
...there has been a considerable increase in the numb...a bacteria transmitted via food. This type, Salmon... least five different antibiotics. Dutch researche...DNA of DT104 that might be involved in its surviva...n might also be involved in the increase in the nu...
...he most popular noun in the English language, yet ... the plethora of watches, clocks and cell phones a...sts have believed that the brain possesses an inte...Now a UCLA study in the Feb. 1 edition of Neuron p...changes to the brain’s cells helps the organ to mo...
... data provide the strongest evidence yet that sudd... disease but has a concrete biological basis. In t...en,s Hospital Boston document abnormalities in the...athing, blood pressure, body heat, and arousal ?in...g cause of death in American infants after the new...
...y compete with large animal scavengers by producin...om consuming valuable food resources -- such as de.... , Ecologists have long recognized microbes as d.... But their role as classic consumers who produce ...an important and common interaction within many ec...
Other Biology News:Salmonella survives better in stomach due to altered DNA 2How does your brain tell time? 2A potential biological cause for sudden infant death syndrome 2A potential biological cause for sudden infant death syndrome 3Microbes compete with animals for food by making it stink 2Microbes compete with animals for food by making it stink 3Microbes compete with animals for food by making it stink 4
(Date:8/21/2008)... NEW YORK, MUNICH, Germany and AMSTERDAM, Neth...thcare and SpePharm Holding, B.V., the,pan-Europea...d that they,have entered into a euro 10 million re...fund SpePharm,s acquisition of Dantrium(R) for Eur...le Pharmaceuticals. At the same,time, TVM Capital,...
(Date:8/20/2008)... VIENNA, Va., Aug. 20 /PRNewswire-USNewswire/ ...0 ranking of the fastest-growing private companies...T) services provider,MicroTech, ranks No. 285 on ... 2008 Inc. 500 list measures revenue growth from 2...U.S.-based, privately held, independent -,no subsi...
(Date:8/20/2008)... INDIANAPOLIS, Ind., Aug. 20 /PRNewswire-First... announced that it has completed the acquisition,o...n Diego-based,biotechnology company focused on dru...y. The completion of the deal followed today,s Spe...SGX stockholders voted in,favor of the merger agre...
(Date:8/20/2008)... Growth Fueled by Popularity with Seniors and ... Marketing, CAMBRIDGE, Mass., Aug. 20 /PRNewswi...hole Health (SWH), a voluntary health care plan fo...ng private company in the,United States., Part of...rowing,companies, SWH had revenue growth of 31,000...
Breaking Biology Technology:TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 2TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 3TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 4TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 5MicroTech Ranks No. 285 on Inc. Magazine's 2008 List of the 500 Fastest Growing Private Companies in America 2Lilly Announces Completion of SGX Acquisition 2Inc. Magazine Names Senior Whole Health the Number One Fastest-Growing Private Company in US 2Inc. Magazine Names Senior Whole Health the Number One Fastest-Growing Private Company in US 3
...uring the 1990s, healthcare again faces the vexing...ing increases in premiums and out-of-pocket costs ..., ,For some time now clinical information technolo...rs of organizations invest millions of dollars in ...der entry (CPOE), electronic medical records, clin...
... authored a book entitled "It Takes a Village" in ...ages of our country surrounding our children were ...dren. , ,While the primary responsibility of child...nded family (friends, neighbors, teachers and othe...the development of the children. , ,Clinton fast f...
...velopments in Washington and Korea could have a la...utting more roadblocks in scientists, search for f...Korean scientists to create "patient-specific" emb...ients, President Bush has renewed his opposition t... on stem-cell research in the United States. Bush ...
...Network is starting up a new Lake Superior chapte...n northwest Wisconsin. , ,WIN organizes networking...ship arm of the Wisconsin Technology Council , a ...lature on technology policy. , ,Other chapters exi...the Fox Valley. , ,Lake Superior chapter organizer...
Other Biology Technology:Innovative health care takes more than just IT automation 2Innovative health care takes more than just IT automation 3Innovative health care takes more than just IT automation 4Creating thousands of jobs, Chicagos biotech space to triple 2Creating thousands of jobs, Chicagos biotech space to triple 3Creating thousands of jobs, Chicagos biotech space to triple 4Creating thousands of jobs, Chicagos biotech space to triple 5Creating thousands of jobs, Chicagos biotech space to triple 6Creating thousands of jobs, Chicagos biotech space to triple 7Creating thousands of jobs, Chicagos biotech space to triple 8Wisconsin aims to keep up in changing stem-cell world 2Wisconsin aims to keep up in changing stem-cell world 3
Rabbit polyclonal to Shigella Immunogen: Mixture of S. boydii, S. flexneri & S. dysenteriae.
...n cullin genes (CUL-1, -2, -3, -4a, -4b, and -5), ...-3 is proposed to be a part of E3 protein-ubiqutin...and targets it for ubiquitination, which leads to ...vator of cdk2, which leads the cell to S phase. Cu...
...ludes interface cable to S2000; can be mounted wit... The LS-450 Blue LED Pulsed Light Source is an L...t at 470 nm -- the blue region -- for fluorescence... Ocean Optics spectrometers configured for fluore...
Clear amber to slightly cloudy liquid. Yellow, oily, bacterial suspension. Contains 10 vials per set, each containing 10 ml of Freund's complete adjuvant homogenized in the following proportions by
Biology Products: