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A single-domain antibody that specifically recognizes amyloid-beta 42 oligomers
Date:1/6/2014

Earlier amyloid-beta assemblies may be one of the most important causes of Alzheimer's disease. Passive immunization of anti-amyloid-beta antibodies can reduce amyloid-beta burden and improved memory performance in various Alzheimer's disease animal models or patients. Screening humanized antibodies from a human Fab phage display library is an effective and quick method to obtain beta-amyloid oligomers. Thus, a recent study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013) successfully constructed a nave human Fab library and obtained a human Fab antibody and a single-domain antibody that specifically recognized amyloid-beta (Aβ)42 oligomers.


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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

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