Navigation Links
A single cell endoscope
Date:12/20/2011

the cells because the illumination volume was so small, down to the picolitre-scale."

Having demonstrated the biocompatibility of their nanowire endoscope, Yang and his co-authors next tested its capabilities for delivering payloads to specific sites inside a cell. While carbon and boron nitride nanotube-based single-cell delivery systems have been reported, these systems suffer from delivery times that range from 20-to-30 minutes, plus a lack of temporal control over the delivery process. To overcome these limitations, Yang and his co-authors attached quantum dots to the tin oxide nanowire tip of their endoscope using photo-activated linkers that can be cleaved by low-power ultraviolet radiation. Within one minute, their functionalized nanowire endoscope was able to release its quantum dot cargo into the targeted intracellular sites.

"Confocal microscopy scanning of the cell confirmed that the quantum dots were successfully delivered past the fluorescently labeled membrane and into the cytoplasm," Yang says. "Photoactivation to release the dots had no significant effect on cell viability."

The highly directional blue laser light was used to excite one of two quantum dot clusters that were located only two micrometers apart. With the tight illumination area and small separation between the light source and the dots, low background fluorescence and high imaging contrast were ensured.

"In the future, in addition to optical imaging and cargo delivery, we could also use this nanowire endoscope to electrically or optically stimulate a living cell," Yang says.

The nanowires used in these experiments were originally developed to study size-dependent novel electronic and optical properties for energy applications.


'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
2. New Columbia engineering technique diagnoses non-periodic arrhythmias in a single heartbeat
3. Smoking a single cigarette may have immediate effect on young adults
4. Single protein, key to ebola virus infection, could aid in drug design
5. Single, key gene discovery could streamline production of biofuels
6. Rapid evolution within single crop-growing season increases insect pest numbers
7. Single gene controls development of many forms of polycystic disease
8. Single GFP-expressing cell is basis of living laser device
9. Improving health assessments with a single cell
10. Scientists observe single gene activity in living cells
11. Species unique to single island should not be rare there
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A single cell endoscope
(Date:6/17/2015)... GARDENS, Fla. , June 17, 2015 /PRNewswire/ ... solutions, today announced that its U.are.U ® ... Togo,s Eateries, Inc., a ... casual sandwich chain, to increase security, improve accountability ... fingerprint readers enable instant, non-repudiable identity confirmation for ...
(Date:6/15/2015)... June 16, 2015 According to ... by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, ... 2020" published by MarketsandMarkets, The Natural Language Processing Market ... CAGR of 18.4% for the forecast period 2015-2020. ... 46 F igures spread   through 155 P ...
(Date:6/10/2015)... June 10, 2015 According ... Market by Technology (Ultrasound, TOF, Structured Light, Stereo ... Entertainment, Automotive) and by Geography - Trends & ... the market is expected to reach $3,319.71 Million ... between 2015 and 2020. Browse 71 ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 53D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4
... over the past 100 years, potentially endangering coast redwood trees ... by University of California, Berkeley, scientists. , It is unclear ... result of human activity, but the change could affect not ... say. , "Since 1901, the average number of hours of ...
... underlying mechanism is shared by a group of previously ... development and function. Rett syndrome (RTT), Cornelia de Lange ... have each been linked with distinct abnormalities in chromatin, ... chromosomes and control how genetic information is read in ...
... cells convert nutrients into energy could offer new approaches ... and stroke. Using a new way to screen ... Hospital (MGH) researchers has identified several FDA-approved agents, including ... metabolism processes in animals. Their findings, being published ...
Cached Biology News:Fog has declined in past century along California's redwood coast 2Fog has declined in past century along California's redwood coast 3Fog has declined in past century along California's redwood coast 4A common thread links multiple human cognitive disorders 2Shifting cellular energy metabolism may help treat cardiovascular disease 2Shifting cellular energy metabolism may help treat cardiovascular disease 3
(Date:6/29/2015)... , ... June 29, 2015 , ... ... B2. Under the terms of the agreement, MediVet will acquire the rights to ... (UCMSCs). MB-007 is currently in pre-clinical development as a potential next-generation treatment for ...
(Date:6/29/2015)... , June 29, 2015  Neuralstem, Inc. (NYSE ... technology to develop small molecule and cell therapy treatments ... has been approved for listing on the NASDAQ Capital ... will continue to trade on the NYSE MKT until ... the NASDAQ Capital Market is expected to commence on ...
(Date:6/29/2015)... 29, 2015 Elsevier , ... products and services, today announced the highlights of its ... 2014 Journal Citation Reports® (JCR) published by Thomson Reuters, ... from 2013 to 2014, ahead of the aggregate across ... rank in 62 subject categories, up from 61 in ...
(Date:6/26/2015)... June 26, 2015  A San Francisco company, Pembient, ... with synthetic rhino horn: beer in China ... . In response to the emerging industry, two ... and sale of synthetic rhino horn.  ... Save the Rhino International (SRI) released a ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... 16, 2012  That our chromosomes can break and reshuffle pieces ... decades, especially in cancer cells. The rules for where chromosomes ... together are only just now starting to come into view. ... Immune Disease Institute (IDI) have helped bring those rules ...
... led by a University of British Columbia professor has developed ... a brief, sudden loss of consciousness in rats, ... seizures, also known as "petit mal seizures," are a symptom ... the person looks awake but dazed. The seizures, arising from ...
... Feb. 15, 2012 The Alfred P. Sloan Foundation ... U.S. and Canadian researchers as recipients of Sloan Research ... are given to early-career scientists and scholars whose achievements ... generation of scientific leaders. "Today,s Sloan Research ...
Cached Biology Technology:To Understand Chromosome Reshuffling, Look to the Genome's 3D Structure 2To Understand Chromosome Reshuffling, Look to the Genome's 3D Structure 3To Understand Chromosome Reshuffling, Look to the Genome's 3D Structure 4New drugs show promise for preventing 'absence seizures' in children: UBC research 2Sloan Research Fellowships Awarded to 126 Young Scholars 2
...
...
Verotoxin IIbeta (457)...
Thermo Labsystems offers a basic reader for 96-well microplates that is especially adapted for ELISA and other colorimetric assays....
Biology Products: