Navigation Links
A single atom controls motility required for bacterial infection
Date:1/4/2010

CHAPEL HILL Bacteria can swim, propelling themselves through fluids using a whip-like extension called a flaggella. They can also walk, strolling along solid surfaces using little fibrous legs called pili. It is this motility that enable some pathogenic bacteria to establish the infections such as meningitis that cause their human hosts to get sick or even die.

Now researchers at the University of North Carolina at Chapel Hill have discovered that a single atom a calcium, in fact can control how bacteria walk. By resolving the structure of a protein involved in the movement of the opportunitistic human pathogen Pseudomonas aeruginosa, the scientists identified a spot on the bacteria, that when blocked, can stop it in its tracks. The finding identifies a key step in the process by which bacteria infect their hosts, and could one day lead to new drug targets to prevent infection.

"When it comes down to it, a single atom makes all the difference," said senior study author Matthew R. Redinbo, Ph.D., professor of chemistry, biochemistry and biophysics at UNC. His findings appear in the Dec. 28, 2009, early online edition of the Proceedings of the National Academy of Sciences.

For the last few years, Redinbo and his team has been working in close collaboration with Matthew C. Wolfgang, Ph.D., an assistant professor of microbiology and immunology and a member of the Cystic Fibrosis/Pulmonary Research and Treatment Center at UNC, trying to figure out how bacteria's tiny legs or pili function. The researchers began to look at one of the many types of pili, called type IV pili. Type IV pili are basically long, dense fibers that bacteria assemble (extension) or disassemble (retraction) quite quickly.

"These pili act as grappling hooks the bacteria extend the fibers out, the fibers attach or stick to a surface, and then retracted back into the bacteria, pulling it along," said Wolfgang. "This crawling movement is calle
'/>"/>

Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
2. Single-largest biodiversity survey says primary rainforest is irreplaceable
3. New technique captures chemical reactions in a single living cell at unprecedented resolution
4. Gene study supports single main migration across Bering Strait
5. Baumann lab identifies elusive telomere RNA subunit in single cell model
6. Ebola virus disarmed by excising a single gene
7. Blue-eyed humans have a single, common ancestor
8. Rice scientists make breakthrough in single-molecule sensing
9. Single-celled bacterium works 24-7
10. RevGenUK, a single-stop shop for use in functional genomics
11. Researchers observe spontaneous ratcheting of single ribosome molecules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A single atom controls motility required for bacterial infection
(Date:9/29/2014)... A University of Texas at Arlington research team says ... built in their lab could open doors for homeland ... be published in the Oct. 1 issue of ... and his co-authors describe a new method to fabricate ... and oxygen until a transparent ceramic is formed. ...
(Date:9/29/2014)... $6 million grant for clinical research and education ... safe and effective treatments for cocaine addiction. , ... of Health, National Institute on Drug Abuse, will ... Cocaine Use Disorder to oversee preclinical and early ... forward with more expensive large-scale clinical trials. , ...
(Date:9/29/2014)... For decades, planetary geologists have speculated that glaciers ... 2000-mile-long chasm that constitutes the Grand Canyon of ... that might have been carved by past glaciers ... observations have remained highly controversial and contested. ... College and the Freie Universitaet Berlin has identified ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3New VCU center to target cocaine addiction 2Glaciers in the Grand Canyon of Mars? 2Glaciers in the Grand Canyon of Mars? 3Glaciers in the Grand Canyon of Mars? 4Glaciers in the Grand Canyon of Mars? 5Glaciers in the Grand Canyon of Mars? 6Glaciers in the Grand Canyon of Mars? 7Glaciers in the Grand Canyon of Mars? 8Glaciers in the Grand Canyon of Mars? 9
... bacteria to become resistant to antibiotics as well as ... January issue of Microbiology . The findings could ... is managed in hospital settings. Researchers from the ... adding increasing amounts of disinfectant to laboratory cultures of ...
... first time that insects, like mammals, use vision rather than ... high-speed video cameras technology the BBC uses to capture ... desert locusts stepping along the rungs of a miniature ladder. ... perform complex tasks, such as visually-guided limb control, usually associated ...
... study recently completed in the gulf coast of Alaska by ... disappears, the production and export of high- quality food from ... could have serious consequences for marine food webs. , The ... matter to the marine environment," was recently published in the ...
Cached Biology News:Disinfectants may promote growth of superbugs 2Ladder-walking locusts show big brains aren't always best 2Glacial watersheds may contribute to oceanic food web 2
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
(Date:9/30/2014)... MA (PRWEB) September 30, 2014 ... (UC) and collaboration company is dedicated to supporting ... connectivity needs. Julie Power, a carrier ... to ensure collaboration solutions stays connected and productive ... to the increased movement of businesses to cloud ...
(Date:9/30/2014)... 30, 2014 UFP Technologies, a ... packaging has recently introduced a custom insulated shipping ... . The new insulated shipper solves the issue ... process. UFP Technologies’ BioShell is a universal storage ... storage, handling and shipping. The insulated shipper keeps ...
(Date:9/30/2014)... September 30, 2014 The ... IACRN), a non-profit organization based in Pittsburgh, Pennsylvania, ... and Safety (ACRES), a Massachusetts non-profit charitable ... alliance agreement, setting the stage for multiple collaborative ... clinical research quality and safety through specialized nursing ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2SoundConnect Expands Carrier Services Division 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3
... Calif., Sept. 21 VaxGen,Inc. (Pink Sheets: VXGN) ... and Exchange Commission (SEC) its Quarterly Report on ... The report can be found at the link,titled ... VaxGen,s web site,at http://www.vaxgen.com . (Logo: ...
... for marketing, NEW YORK, Sept. 21 Small ... and education for the,small bone and joint sector of ... been cleared by the FDA for marketing in the ... implanted, degradable,spacers to four applications with two others planned ...
... Inc. (Nasdaq:,CEPH) today announced that it has submitted ... and Drug Administration (FDA) requesting approval of,TREANDA(R) (bendamustine ... leukemia (CLL). CLL is a slowly progressing blood ... cases diagnosed every year in,the United States, according ...
Cached Biology Technology:VaxGen Files First Quarter 2007 Financials 2Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 2Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 3Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 4Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 5Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia 2Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia 3Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia 4
TNM-FH Insect Medium 1 liter...
IHC Polymer Detection Kit (Rabbit DAB)150 slides...
Performance, mycoplasma, virus, and endotoxin tested. Collected from calves 14 days old or less...
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
Biology Products: