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A second pathway for antidepressants
Date:2/7/2011

sence of fluoxetine when the tail is still attached to the rest of the TREK1 protein. In the meantime, Isacoff and his team feel they now have a valuable assay that can be used to monitor the reversible plasma membrane association of protein domains without the need for scanning, optical slicing or imaging.

"Pharmaceutical companies screening for potential new drugs, such as improved antidepressants, prefer assays that are fast and simple," Isacoff says. "Our technique can be used to follow changes in lipid composition that result from membrane signaling events, or to study the binding to membranes by cytoplasmic regulatory domains of ion channels. This could be very useful for pharmaceutical research."


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Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

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