Navigation Links
A screening strategy using zebrafish targets genes that protect against hearing loss
Date:2/29/2008

ement of fluid (triggered by sound vibrations in the inner ear or changes in water pressure in the fishs environment) causes the stereocilia to tilt to one side, generating an electrical impulse that travels to the brain.

The researchers first set out to identify genes that may be involved in how hair cells respond to ototoxic medicines. Using a chemical that causes random mutations in zebrafish, the researchers bred various fish families, with each family exhibiting a different set of mutations. The researchers then exposed five-day-old larval offspring to the drug neomycin, a type of antibiotic that damages these hair cells as well as those in the human inner ear. The larvae were then stained to determine if the hair cells were still intact. Fish that were resistant to damage were quickly identified as were those that were especially vulnerable.

Using genetic techniques, the group then examined the larvaes DNA, searching for segments that were closely tied to the desired property. In doing so, they zoomed in on five mutationseach located on different genesthat, when inherited from each parent, protected against hair cell damage. Further examination revealed that one of the identified genes corresponds to a gene that is also found in other vertebrates, including humans. Another five mutations were identified that offer protection under more complex genetic conditions.

Next, the team investigated whether they could identify chemical compounds that protect hair cells against ototoxic medicines. Using the same screening techniqueexposing five-day-old zebrafish larvae to neomycin and later applying special stains to the hair cellsthe researchers screened more than 10,000 compounds and narrowed them down to two similar chemicals that provide robust protection of hair cells against the neomycin. One of the compounds was later found to protect hair cells from a mouses inner ear against the drug, indicating that the same compound may be protecti
'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UNC study questions FDA genetic-screening guidelines for cancer drug
2. MIT: Micro livers could aid drug screening
3. New screening strategy for detection of chagas disease in children
4. Simple screening questionnaire for kidney disease outperforms current clinical practice guidelines
5. Embryonic stem cell strategy advanced with UCSF finding
6. Penn Veterinary Medicine report new strategy to create genetically-modified animals
7. Bee strategy helps servers run more sweetly
8. Lupus Research Institute strategy delivers $30 million in national funding
9. Texas Hospital nations first to use large-scale cocoon strategy against whooping cough
10. Carbon capture strategy could lead to emission-free cars
11. Strategy for nanotechnology-related environmental, health and safety research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2, 2015  Businesses have a new option ... Tharon Rankins Enterprises has announced the launch of ... way for businesses to protect their customers, personal ... Beconux is a biometric transaction processing ... similarly to an ATM machine, the new system ...
(Date:2/24/2015)... Feb. 24, 2015 This report analyzes the worldwide ... separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Middle East ... estimates and forecasts are provided for the period 2013 through ... markets. Market data and analytics are derived from primary and ...
(Date:2/23/2015)... Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... patent 62114357 for DISTRIBUTED VOICE DIRECTED PAYMENT ... introduces a new groundbreaking payment method. Payment accounts may ... may only be accessed if both the speech (the ...
Breaking Biology News(10 mins):Personal Data Protection Company Launches New Product 2World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
... ductal adenocarcinoma is an almost uniformly fatal disease regardless ... small percentage of patients develop a form of ductal ... earlier, is less aggressive and has a 50 percent ... differently, despite carrying the same basic genetic mutations as ...
... the University of Rochester Biomedical Engineering Department has invented ... stem cells. When he captures cancer cells, he ... harvests them for later use in tissue engineering, bone ... and improve health. With Nichola Charles, Jared Kanofsky, ...
... year to the UK poultry industry but scientists are now ... ?one that can be delivered while they are still in ... provides immunity to IBV has been developed by scientists at ... UK. It can be delivered to chicks still in the ...
Cached Biology News:Genetic pathways to curable and incurable forms of pancreatic cancer identified 2Genetic pathways to curable and incurable forms of pancreatic cancer identified 3Cancer-killing invention also harvests stem cells 2Cancer-killing invention also harvests stem cells 3Cancer-killing invention also harvests stem cells 4In-shell vaccine for chick disease 2
(Date:3/3/2015)... The winners of awards for supply ... the Global Supply Chain Resiliency Council (GSCRC) ... Wednesday, February 25th, 2015, at the Hyatt Regency in ... bring together supply chain risk management and resiliency practitioners ... discipline through opportunities to collaborate, develop and share best ...
(Date:3/3/2015)... March 3, 2015  Thingee Corporation, a software development ... a presentation entitled, "Technology Adoption: Making Reps, Lives Easier" ... Innovations and Technology ,  in Deerfield Beach, ... 13, 2015. Audiences looking to learn how technology can ... to be in the audience for the Thingee presentation. ...
(Date:3/3/2015)... Kindred Biosciences, Inc. (NASDAQ: KIN ), ... of pets, announced today that it will release its fourth ... after the market close. The Company will host a conference ... Interested parties may access the call by dialing toll-free ... using conference ID 98449349.  The call will ...
(Date:3/3/2015)... Mass. (PRWEB) March 03, 2015 Cambridge ... by Semantic Web technology, today announced that it has ... Companies That Matter in Knowledge Management.’ , To ... group of colleagues, analysts and system integrators who identify ... delivery of the right information to the right people ...
Breaking Biology Technology:Global Supply Chain Resiliency Council Names Award Winners 2Global Supply Chain Resiliency Council Names Award Winners 3Global Supply Chain Resiliency Council Names Award Winners 4Thingee to present at 11th Annual Synergistix Users Conference 2Cambridge Semantics Named to KMWorld’s 2015 ‘100 Companies That Matter in Knowledge Management’ 2
... SHANGHAI, July 10 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc.,(Nasdaq: ... in the research, development, manufacture, marketing and,distribution of probiotics ... at 10:00 a.m. EDT on Wednesday, July 15, 2009, ... and full year ended March,31, 2009. , ...
... Corporation (NYSE: SGP ) today announced ... Japan, has received marketing approval for REMERON(R) /Reflex(R) ... depressive disorder.(1) The product was developed jointly with ... Seika will market the product under the trade ...
... MADRID, July 9 , ... take part in an online,seminar entitled "Business Opportunities in the Biotechnology, ... for,foreign companies in the sector in Spain. Experts will respond to ... seminar will be held on the 14th of July (12:00pm - ...
Cached Biology Technology:China-Biotics, Inc. Announces Conference Call to Discuss Fourth Quarter and Full Year 2009 Financial Results 2REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 2REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 3REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 4REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 5Business Opportunities in Spain's Fast-Growing Biotechnology Industry 2
Anti-Flavocytochrome b Monoclonal, FITC Labeled Research Focus: other Storage: 4C Shipping Temperature: 4C...
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
... Rabbit polyclonal to MKK6 (phospho S207) ... applications). Antigen: ... around the phosphorylation site of Serine ... Entrez Gene ID: 5608 ...
Rabbit polyclonal to Reptin/TIP49B/RUVB2 ( Abpromise for all tested applications). Antigen: Synthetic peptide (Human) Entrez Gene ID: 10856 Swiss Protein ID: Q6FIB9...
Biology Products: