Navigation Links
A scientific breakthrough on the control of the bad cholesterol
Date:11/24/2008

Montral, November 24, 2008 A study performed by the team of Dr. Nabil G. Seidah, Director of the Biochemical Neuroendocrinology Research Unit at the IRCM, shows for the very first time that the degradation by PCSK9 of the LDLR receptor, which is responsible for removing the bad cholesterol (LDL-cholesterol) from the bloodstream, may be inhibited by a third protein, annexin A2. This major discovery co-authored by Gatan Mayer, a postdoctoral fellow, Steve Poirier, a doctoral student, and Dr. Seidah was published on November 14 in the Journal of Biological Chemistry (JBC).

Genetic studies on humans have clearly shown that PCSK9 is a prime therapeutic target for the prevention and treatment of cardiovascular diseases. PCSK9 proprotein convertase promotes the degradation of the receptor responsible for eliminating LDL-cholesterol particles. Thus, the presence of PCSK9 leads to a surplus of bad cholesterol in the bloodstream and contributes to plaque formation, leading to blockage of blood vessels and arteries. This phenomenon is a major risk factor that can lead to cardiovascular diseases, such as heart attack, atherosclerosis and stroke. Mutations of human genes have demonstrated that a rise in PCSK9 activity results in a major increase in LDL-cholesterol and familial hypercholesterolemia. Conversely, in people with a non-functional mutation in the gene coding for PCSK9, a decrease in its activity brings down the LDL-cholesterol concentration levels in the bloodstream and diminishes by up to 88% the risks of developing cardiovascular diseases.

"By performing a series of biochemical experiments, we discovered that annexin A2 binds strongly to PCSK9 and inhibits its function," remarks Gatan Mayer, the article's first author. This discovery should pave the way toward the development of a new drug that would lower blood cholesterol to recommended levels. Currently, cholesterol lowering drugs known as "statins" are used by more than 25 m
'/>"/>

Contact: Nabil G. Seidah
seidahn@ircm.qc.ca
514-987-5609
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Barrow scientists solve 200-year-old scientific debate involving visual illusions
2. Scientific community called upon to resolve debate on net energy once and for all
3. Top scientific meeting urges coordinated response to economic and environmental crises
4. Loggerhead release to provide vital information to scientific community
5. NIAID scientists to speak on range of infectious disease topics at major scientific meeting
6. ETH Zurich-administered fund ends scientific anonymity
7. Gene therapy anti-cancer research featured in Scientific American
8. In scientific first, Einstein researchers correct decline in organ function associated with old age
9. The emerging scientific discipline of aeroecology
10. Significant impact factor boost for scientific journal Genome Research
11. Scientific information largely ignored when forming opinions about stem cell research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... unveiled today by researchers from several Harvard University ... both experienced and aspiring researchers with the intellectual ... robots made from soft, flexible materials. , With ... and other advances in manufacturing technology, soft robotics ... principles drawn from conventional rigid robot design, but ...
(Date:9/19/2014)... A University of Oklahoma biology professor will study ... control leg movements with a National Science Foundation ... four-year project. , Ari Berkowitz, professor in the ... Sciences, will focus on the differences between the ... understand what neurotransmitters they use and what connections ...
(Date:9/19/2014)... a species which over thousands of years has adapted to ... substance that makes the cold dangerous for you. , This ... , and the cold provoking substance, called nonylphenol, comes from ... is suspected of being a endocrine disruptor, but when entering ... worm,s ability to protect the cells in its body from ...
Breaking Biology News(10 mins):Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... After several years of battling recurring infections, the last thing ... cause of her problems might actually help millions live longer, ... Goetzl and his colleagues from the University of California and ... unique antibody to her own T cells, the cells that ...
... Research has shown that certain marginalized groups including ... as African Americans and Latinos fare worse than ... impoverishment, injuries and fatalities. Now, ... found that they also experience greater terrorism-related fears and ...
... (January 21, 2008)- Jizhou Song, a professor in the ... collaborators Professor John Rogers, at the University of Illinois ... a new design for stretchable electronics that can be ... function. , The new mechanical design strategy is ...
Cached Biology News:Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection 2Disabled and other vulnerable groups more susceptible to terrorism fears 2University of Miami engineer designs stretchable electronics with a twist 2
(Date:9/19/2014)... that use light, rather than electricity, to move ... energy efficiency is a growing concern as chips, ... components of optical circuits light emitters, modulators, ... build. One promising light source for optical chips ... properties when deposited as a single, atom-thick layer. ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
(Date:9/19/2014)... September 19, 2014 Cereal grain ... industries will gather October 5–8, 2014, for the ... Island Convention Center in Providence, Rhode Island. The ... work of food scientists, chemists, microbiologists, nutritionists, and ... food production management. To date, 1,000 attendees have ...
(Date:9/18/2014)... Bipartisan passage this week by the U.S. ... development and commercialization of new technologies and promote growth ... SPIE, the international society for optics and photonics ... (RAMI) Act, now moves to the full Senate for ... optimistic that it will win passage there as well ...
Breaking Biology Technology:Toward optical chips 2Toward optical chips 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3
... AMLN ) will be presenting at the Morgan Stanley Global ... ET / 7:55 a.m. PT in ... Tuesday, September 14, 2010 at 11:30 a.m. ET / 8:30 ... president and chief executive officer of Amylin Pharmaceuticals, will provide a corporate ...
... has great potential to make electronic devices such as radios, ... have also led to difficulties in integrating the material into ... 1 in the journal Nature , a group of ... difficulties to fabricate the fastest graphene transistor to date. ...
... for Biochemistry and Molecular Biology expressed its disapproval and ... ruling in the U.S. District Court for the District ... funding of embryonic stem-cell research. In a ... response to a lawsuit filed by two adult stem-cell ...
Cached Biology Technology:UCLA chemists, engineers achieve world record with high-speed graphene transistors 2American Society for Biochemistry and Molecular Biology Reacts to District Court Stem-Cell Ruling 2
Human Legumain Affinity Purified Polyclonal Ab...
Human Siglec-9 Biotinylated Affinity Purified Pab...
TUNEL Apoptosis Detection Kit...
... NOS activity by monitoring the conversion of ... simple, sensitive, and specific for NOS activity ... and purified enzyme preparations. The kit includes ... reactions. Radiolabeled arginine and NADPH are not ...
Biology Products: