Navigation Links
A scientific breakthrough could be the first step in a better treatment for leukemia patients
Date:9/16/2010

Khandanpour. "Among other reasons, these patients die because the transplanted stem cells do not generate new blood cells quickly enough, which leads to infection and death."

"We have found a protein (called Gfi1b) that seems to regulate the stem cells' activity level and where they reside in the bone," says Dr. Khandanpour. "In our mouse model, we were able to turn off the gene coding for Gfi1b. When we did this, the stem cells became activated, started expanding drastically, left their bone marrow niche and entered the bloodstream without losing their function. The ability to manipulate blood stem cells in this manner would significantly increase the efficiency of stem cell therapy."

According to the researchers, the inactivation of Gfi1b in the transplanted stem cells could accelerate the production of new blood cells, thus making stem cell therapy more efficient and less dangerous for the patient. However, the mechanisms regulating stem cell dormancy and mobilization are not well understood.

"Our next goal is to investigate the precise molecular mechanisms achieved by the ablation of Gfi1b, and to study in more detail how Gfi1b regulates the location and activation of blood stem cells," adds Dr. Mry. "Our project will contribute to a better understanding of the biology of stem cell mobilization and dormancy, which could lead to the design of better treatment regimens for transplant donors and patients."

According to The Leukemia & Lymphoma Society of Canada, one person is diagnosed with a blood cancer every four minutes and someone dies from a blood cancer every 10 minutes. This statistic represents over 54,000 people per year. Leukemia causes more deaths than any other cancer among children and young adults under the age of 20.


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon hosting first conference to explore scientific use of gigapixel imagery
2. A plan to promote sustainable US scientific discovery and innovation in the 21st century is proposed in OMICS
3. Honorary Fellowship awarded to government Chief Scientific Advisor
4. At opening of XVIII International AIDS Conference, scientific, community and political leaders applaud recent progress toward universal access and urge continued momentum to finish what weve started
5. Scientific coral reef survey to be conducted in Bonaire
6. Wellcome-Wolfson partnership makes £30 million investment in UK scientific infrastructure
7. Scientific expertise lacking among doubters of climate change, says Stanford-led analysis
8. Canadian research examines effects of scientific claims on oil
9. Gregory Downey, M.D., of National Jewish Health, honored for scientific accomplishments
10. IOF Medal of Achievement for outstanding scientific contributions awarded to John A. Kanis
11. UC Riverside plant cell biologist receives top scientific honor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... 6, 2015  Today, U.S. Congressman Mike ... ™ to learn firsthand how Silicon Valley technologies ... is a world leader in multi-factor identity management ... helping federal agencies and commercial organizations achieve new ... "The vast majority of network breaches can ...
(Date:8/5/2015)... 5, 2015 According to a ... Market by Software, Services, Vertical (BFSI, Airport, IT & Telecom, ... Global Forecast to 2020", published by MarketsandMarkets, defines and ... into various segments. The global PIAM Market is estimated ... Million by 2019, at a CAGR of 14.9 % ...
(Date:8/4/2015)... Aug. 04, 2015 ... has announced the addition of the ... and Service), Sub-Segment (Computer Forensics, Network Forensics, ... Types, Service, Vertical and Region - Global ... offering. By Component (Hardware, Software, ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... for the loss of millions of hours of work productivity this ... fever symptoms, including sneezing, watery eyes and runny and itchy noses, ... peak hay fever season. , While missing an hour of ... million Americans suffer from at least some symptoms related to hay ...
... normal baby. He hit all his developmental landmarks but after his ... with infection after infection. He stopped eating and was no longer ... or even looking at us anymore; he was in his own ... not potty trained, and was smearing (feces) on the walls. My ...
... at University of Copenhagen have identified a new group of ... are published in the new issue of Cell. , All ... specialised cell types that all originate from the same type ... develop into any type of cell through a carefully regulated ...
Cached Biology News:Hay fever can send work productivity down the drain 2Hay fever can send work productivity down the drain 3Army research mission focused on autism 2Army research mission focused on autism 3Army research mission focused on autism 4
(Date:8/26/2015)... , ... August 26, 2015 , ... ... announces today that a second US laboratory is to open in Manhattan, Kansas ... the continued partnership and long-term growth of research and development through collaboration with ...
(Date:8/26/2015)... FRANCISCO , Aug. 26, 2015  Platform ... that it has received a $1.5M Phase II ... (NIH) to further develop its therapeutic agent to ... clinical need in end stage renal disease (ESRD) ... the National Institute of Diabetes and Digestive and ...
(Date:8/26/2015)... Florida , August 26, 2015 ... the biggest factors fueling the optimism in biotech,s ... M&A,s, collaborations and life sciences advancements.  Active biotechnology ... are Pressure BioSciences, Inc. (OTCQB: PBIO), Sequenom, Inc. ... SRPT ), Raptor Pharmaceutical Corp. (NASDAQ: ...
(Date:8/25/2015)... ... August 25, 2015 , ... Vets Plus, Inc. ... Wis. The company has added a AS16 Sharples centrifuge to harvest products after ... bacterial or fungal fermentation process development. , The new centrifuge greatly expands ...
Breaking Biology Technology:MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7New centrifuge and fermentor expand product development capacity at Vets Plus 2
... VIENNA, Austria, March 12 f-star, an antibody,engineering ... its unique Modular Antibody Technology, announced today that ... in addition to its,headquarters in Vienna, Austria. The ... home to a number of biotech companies and ...
... March 12 iCAD, Inc. (Nasdaq:,ICAD), an industry-leading ... detection of cancer, today announced that John,DeLucia has ... Assurance and,Regulatory Affairs, reporting to iCAD President and ... years of medical device, in-vitro diagnostics,and biomedical research ...
... REDWOOD CITY, Calif., March 12 Genomic,Health, Inc. ... Scott, Ph.D.,Genomic Health,s Chairman and Chief Executive Officer, ... Healthcare Conference in Miami, FL,on March 19, 2008 ... the live and subsequently archived webcast of the,presentation, ...
Cached Biology Technology:Antibody Engineering Company f-Star Opens Second Research Site in Cambridge, UK 2iCAD Appoints John DeLucia as Vice President of Quality Assurance and Regulatory Affairs 2iCAD Appoints John DeLucia as Vice President of Quality Assurance and Regulatory Affairs 3Genomic Health to Present at Lehman Brothers Global Healthcare Conference 2