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A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
Date:2/13/2014

other than vertebrates". Simply stated p66Shc acts to suppress insulin signaling and energy metabolism when glucose levels are high, as in the case of diabetes.

Mohamed Soliman is a Vanier scholar and was mentored by the late Dr. Tony Pawson whose research is credited for pioneering the field of signal transduction by first describing in the 1980's that proteins contain modular domains that allow them to interact with each other to control cellular communication. He is currently working in the laboratory of Dr. Jim Dennis, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, and a professor at the University of Toronto. This study has been done in collaboration with Dr. David Sabatini at the Massachusetts Institute of Technology.


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Contact: Mohamed Soliman
ma.soliman@utoronto.ca
Lunenefeld-Tanenbaum Research Institute
Source:Eurekalert  

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