Navigation Links
A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
Date:2/13/2014

[TORONTO,Canada, Feb 18, 2014] A protein that has been known until recently as part of a complex communications network within the cell also plays a direct role in regulating sugar metabolism, according to a new study published on-line in the journal Science Signaling (February 18, 2014).

Cell growth and metabolism are tightly controlled processes in our cells. When these functions are disturbed, diseases such as cancer and diabetes occur. Mohamed Soliman, a PhD candidate at the Lunenfeld Tanenbaum Research Institute at Mount Sinai Hospital, found a unique role for the p66Shc adaptor protein in regulating glucose metabolism and cell growth. This report could lay the foundation for future studies to target adaptor proteins in cancer and diabetes therapy.

Proteins are functional units of cells that assemble in a precise manner to control cellular processes. Specifically, adapter proteins act as linkers or switches to fine tune cellular functions. Soliman and colleagues became interested in p66Shc adaptor protein after reading that mice deficient in it have a greatly increased lifespan and show no signs of cancer. p66Shc mice also have better glucose tolerance and are resistance to the development of obesity and diabetes. These findings prompted Soliman to take novel approaches to elucidate the mechanism to explain these findings. Briefly, Soliman explains "we found when silencing the adaptor p66Shc in cells, enhances not only glucose metabolism, but also the metabolism of and molecules involved in the making the cells building blocks, resulting in overall increased cell growth."

Thus, p66Shc may have evolved to be a switch that responds to nutrient availability. This role of p66Shc as a sensor of energy levels appears to be unique to higher level organisms explains Soliman's mentor Dr. Jim Dennis "the gene responsible for p66Shc protein expression is relatively new by evolution standards, as it is not seen in species other than vertebrates". Simply stated p66Shc acts to suppress insulin signaling and energy metabolism when glucose levels are high, as in the case of diabetes.

Mohamed Soliman is a Vanier scholar and was mentored by the late Dr. Tony Pawson whose research is credited for pioneering the field of signal transduction by first describing in the 1980's that proteins contain modular domains that allow them to interact with each other to control cellular communication. He is currently working in the laboratory of Dr. Jim Dennis, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, and a professor at the University of Toronto. This study has been done in collaboration with Dr. David Sabatini at the Massachusetts Institute of Technology.


'/>"/>

Contact: Mohamed Soliman
ma.soliman@utoronto.ca
Lunenefeld-Tanenbaum Research Institute
Source:Eurekalert  

Related biology news :

1. New study finds no reason to replace fructose with glucose
2. Glucose: Potential new target for combating annual seasonal influenza
3. Study: Metformin for breast cancer less effective at higher glucose concentrations
4. People with impaired glucose tolerance can show cognitive dysfunction
5. Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
6. FASEB SRC announces conference: Glucose transport -- Gateway for Metabolic Systems Biology
7. Anchoring proteins influence glucose metabolism and insulin release
8. Engineers use droplet microfluidics to create glucose-sensing microbeads
9. New, designer fiber may help address fiber intolerance and ease IBS symptoms
10. Overexpression of cytoglobin gene increases neuronal hypoxic tolerance
11. Early exposure to insecticides gives amphibians higher tolerance later
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
(Date:2/2/2016)... , Feb. 2, 2016 This ... the bioinformatic market by reviewing the recent advances ... tools that drive the field forward. Includes forecast ... Identify the challenges and opportunities that exist ... and software solution developers, as well as IT ...
(Date:2/2/2016)... MOUNTAIN VIEW, Calif. , Feb. 2, 2016 ... diabetic retinopathy market, Frost & Sullivan recognizes US-based ... North America Frost & Sullivan Award for New ... technology provider in North America ... standard in the rapidly growing diabetic retinopathy market. ...
(Date:1/28/2016)... -- Synaptics (NASDAQ: SYNA ), a leading developer of human ... December 31, 2015. --> --> ... 2 percent compared to the comparable quarter last year to $470.5 ... $35.0 million, or $0.93 per diluted share. ... quarter of fiscal 2016 grew 9 percent over the prior year ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... International, a not-for-profit organization focused on the ethics and governance ... to patients around the world, today announced that the editors ... the Good Pharma Scorecard an ,Editors, Pick, ... of BMJ Open ,s ,Most Popular Articles, which includes ... read. Ed Sucksmith , assistant editor of ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... focused on the development and manufacture of biopharmaceuticals and therapeutics, announces an ... the 2016 BioProcess International Awards – Recognizing Excellence in the People, Organizations ...
(Date:2/11/2016)... 2016   BioInformant announces the February 2016 ... Products, Opportunities, Tools, and Technologies – Market Size, Segments, ... The first and only ... industry, BioInformant has more than a decade of historical ... by stem cell type. This powerful 175 page global ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
Breaking Biology Technology: