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A revolutionary new model for Alzheimer's disease
Date:2/19/2009

ed, but it also shut down the production of the amyloid, all of which makes it an interesting potential therapeutic.

"I think we're going to see an explosion in the next five years involving the dissection of these signaling pathways whose imbalance leads to Alzheimer's disease," said Buck Institute Faculty Member Dale Bredesen, MD, who led the California half of the French-Californian collaborative research. "We now believe that APP is part of a 'plasticity module' that functions in normal memory and forgetting, and that netrin-1 gives us an important starting point to restore the normal balance."

"We believe that Alzheimer's disease is somewhat analogous to cancer, which results from an imbalance between the normal processes that support cell survival and those that cause cell turnover," said Patrick Mehlen, PhD, Director of the Apoptosis, Cancer and Development CNRS Laboratory at the University of Lyon and co-senior author of the study. "Our hope is that this research will lead to therapeutics that will be used to address this imbalance much earlier in the disease process."

Research is underway to develop a drug based on the findings. The Buck Institute and the CNRS in Lyon are partnering with Neurobiological Technologies Inc., (NASDAQ: NTII) to bring the discovery from the laboratory to clinical trials.


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Contact: Kris Rebillot
krebillot@buckinstitute.org
415-717-3268
Buck Institute for Age Research
Source:Eurekalert

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