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A region and pathway found crucial for facial development in vertebrate embryos
Date:7/17/2014

first author of the Cell Reports paper along with postdoctoral researcher Radek Sindelka, who now heads a research group in Prague, Czech Republic.

It is unclear whether similar mechanisms are at play in mammals, including humans. Sive, however, hints that there may be a connection. She notes that certain blood pressure medications, which act on parts of the Kinin-Kallikrein pathway, can cause severe craniofacial defects in newborns if taken during pregnancy. Although such defects have been attributed to effects mediated by the kidneys, Sive's latest findings may implicate Kinin-Kallikrein signaling.


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Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

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