Navigation Links
A reductionist approach to HIV research
Date:11/30/2009

A major obstacle to HIV research is the virus's exquisite specialisation for its human host meaning that scientists' traditional tools, like the humble lab mouse, can deliver only limited information. Now, a team of researchers writing in BioMed Central's open access Journal of Biology have made an ingenious assault on this problem by creating a mouse that has key features of HIV infection without being infected with HIV.

George Kassiotis, from the Division of Immunoregulation at MRC National Institute for Medical Research, worked with a team of researchers to create mice whose CD4+ T cells, the cells eliminated by HIV infection, commit a kind of suicide upon activation. He said, "Although these mice do not fully reproduce every aspect of human HIV-associated immune dysfunction, they do approximate two key immune alterations - CD4+ T cell immune deficiency and generalized immune activation. Further definition of the precise balance between CD4+ T cell killing and immune activation and deficiency will be vital to our understanding of the pathogenesis of immune deficiency virus infection."

The CD4+ T cells in the researchers' mice were engineered to express a toxin, diphtheria toxin A fragment, upon activation. This genetic self-destruct system causes the death of the cell within 48 hours. The resultant loss of activated immune cells caused the mice to exhibit symptoms with some similarities to those of immunodeficiency virus infection. There are clear differences between the mouse and a human infected with HIV, however, such as the fact that the ongoing depletion of nearly all activated CD4+ T cells in the mice does not result in the progressive erosion of nave and memory CD4+ T cells seen during HIV infection. None-the-less, insights gained from this reductionist model can only help our understanding of human disease. In a commentary on the work in the same issue of Journal of Biology, experts on T cells and HIV at the US National Institutes of Health comment that the mouse will be as useful for its differences from human infection as it will for its similarities.


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-319-22165
BioMed Central
Source:Eurekalert

Related biology news :

1. ORNL, Los Alamos pioneer new approach to assist scientists, farmers
2. Kill the cancer, not the patient: New toxicity testing approach could make chemo drugs safer
3. UTs Valentin Dragoi gets $1.2 million grant for groundbreaking approach to brain research
4. Systems biology recommended as a clinical approach to cancer
5. New tracking approach will help protect polar bears
6. Manatees can probably hear which directions boats approach from
7. Equity concerns raised by congestion pricing can be addressed to make approach viable
8. Combined stem cell-gene therapy approach cures human genetic disease in vitro
9. Rapid approach to identify influenza A virus mutations and drug resistance developed
10. Novel vaccine approach offers hope in fight against HIV
11. Stowers researchers develop whole genome sequencing approach for mutation discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
(Date:6/24/2016)... ... , ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension ... are higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... bottom of the cuvette holder. , FireflySci has developed several Agilent flow cell ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
Breaking Biology Technology: