Navigation Links
A reductionist approach to HIV research
Date:11/30/2009

A major obstacle to HIV research is the virus's exquisite specialisation for its human host meaning that scientists' traditional tools, like the humble lab mouse, can deliver only limited information. Now, a team of researchers writing in BioMed Central's open access Journal of Biology have made an ingenious assault on this problem by creating a mouse that has key features of HIV infection without being infected with HIV.

George Kassiotis, from the Division of Immunoregulation at MRC National Institute for Medical Research, worked with a team of researchers to create mice whose CD4+ T cells, the cells eliminated by HIV infection, commit a kind of suicide upon activation. He said, "Although these mice do not fully reproduce every aspect of human HIV-associated immune dysfunction, they do approximate two key immune alterations - CD4+ T cell immune deficiency and generalized immune activation. Further definition of the precise balance between CD4+ T cell killing and immune activation and deficiency will be vital to our understanding of the pathogenesis of immune deficiency virus infection."

The CD4+ T cells in the researchers' mice were engineered to express a toxin, diphtheria toxin A fragment, upon activation. This genetic self-destruct system causes the death of the cell within 48 hours. The resultant loss of activated immune cells caused the mice to exhibit symptoms with some similarities to those of immunodeficiency virus infection. There are clear differences between the mouse and a human infected with HIV, however, such as the fact that the ongoing depletion of nearly all activated CD4+ T cells in the mice does not result in the progressive erosion of nave and memory CD4+ T cells seen during HIV infection. None-the-less, insights gained from this reductionist model can only help our understanding of human disease. In a commentary on the work in the same issue of Journal of Biology, experts on T cells and HIV at the US National Institutes of Health comment that the mouse will be as useful for its differences from human infection as it will for its similarities.


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-319-22165
BioMed Central
Source:Eurekalert

Related biology news :

1. ORNL, Los Alamos pioneer new approach to assist scientists, farmers
2. Kill the cancer, not the patient: New toxicity testing approach could make chemo drugs safer
3. UTs Valentin Dragoi gets $1.2 million grant for groundbreaking approach to brain research
4. Systems biology recommended as a clinical approach to cancer
5. New tracking approach will help protect polar bears
6. Manatees can probably hear which directions boats approach from
7. Equity concerns raised by congestion pricing can be addressed to make approach viable
8. Combined stem cell-gene therapy approach cures human genetic disease in vitro
9. Rapid approach to identify influenza A virus mutations and drug resistance developed
10. Novel vaccine approach offers hope in fight against HIV
11. Stowers researchers develop whole genome sequencing approach for mutation discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ) ... "Global Facial Recognition Market 2016-2020" report ... ) has announced the addition of the ... report to their offering. --> ... announced the addition of the "Global ...
(Date:2/3/2016)... Vigilant Solutions announces today that the ... Missouri solved two recent hit-and-run cases with ... Vigilant Solutions. Brian Wenberg explains, "I ... was walking out of a convenience store and witnessed an elderly male back ... striking his vehicle and leaving the scene.  In his ...
(Date:2/2/2016)... Checkpoint Inhibitors for Cancer – Explore ... you interested in the future of cancer drugs? ... Visiongain,s report gives those predictions to 2026 at ... Avoid falling behind in data or losing ... those emerging cancer therapies can achieve. There you ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... R&D program for the development of future natural products for ... research and development center in Israel ... Stockton has a variety of products adapted ... active in more than 35 counties worldwide. ... flagship product Timorex Gold ® is used to control ...
(Date:2/5/2016)... 2016 ATCC, the premier global biological materials ... medical and life science researchers that are working to ... CDC website . --> ... is a single-stranded RNA virus of the Flaviviridae family, ... and Chikungunya Viruses. Zika virus is transmitted to humans ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf Media Inc ., ... interactive FDA compliance training course, Writing Effective SOPs (Standard ... interactive course on Morf Playbook—now conveniently available on smartphones and PCs--provides step by ...
(Date:2/4/2016)... 2016 Beike Biotechnology, the Shenzhen ... a ceremony in late 2015 to mark their successful ... 2016. --> --> ... Personalized Cell Therapy" was hosted by the Shenzhen Cell ... subsidiaries of Beike Biotechnology Co., Ltd. ...
Breaking Biology Technology: