"Our team identified three regions in ELMO that allow it to toggle between a closed/inactive and open/active shape," adds Dr. Yoran Margaron, a postdoctoral fellow in the same research unit and one of the article's co-authors. "We showed that if we disrupt ELMO's regulatory feature and maintain the protein in an open state, we can fully activate the DOCK180/Rac pathway and significantly increase the migration potential of cells."
The researchers' next step is to investigate the regulation of ELMO in cancer cells. Based on their latest findings, they will attempt to maintain ELMO in a repressed state within cancer cells to prevent metastasis, which could have a major impact on the development of potential cancer treatments.
|Contact: Julie Langelier|
Institut de recherches cliniques de Montreal