Navigation Links
A recent IRCM breakthrough impacts cancer research
Date:10/28/2010

Montreal, October 28, 2010 A team of scientists at the Institut de recherches cliniques de Montral (IRCM) led by Dr. Jean-Franois Ct, Director of the Cytoskeletal Organization and Cell Migration research unit, identified a novel molecular mechanism in the control of cell motility. Their findings were published online today in Current Biology, a journal from the Cell Press group. This scientific breakthrough could eventually lead to the development of new cancer-treating drugs that could block the spread of tumours (metastasis).

"As many as 90% of cancer patient deaths are attributable to metastasis, which explains the importance of understanding the molecular mechanisms at the basis of this harmful process," says Dr. Ct. "This is why, over the past few years, we have focused our research on DOCK180, a protein involved in intracellular signalling networks, and more particularly on the DOCK180/Rac1 signalling pathway, which is suspected to be a key mediator of tumour metastasis."

Unlike normal cells that migrate throughout embryonic and adult life to perform their specialized functions, cancer cells metastasize in order to lethally spread throughout the body. At a molecular level, DOCK180 specifically activates the small Rac1 protein, which, in turn, modifies a cell's shape and promotes cell motility and invasion. Dr. Ct's team had previously demonstrated in detail how DOCK180, with the help of its binding partner ELMO, acts on Rac1 to promote robust cell migration.

"We knew that this signalling pathway had to be regulated to prevent uncontrolled cell migration in normal conditions, but until now, the mechanisms involved had been eluding us and other scientists," explains Manishha Patel, a PhD student in Dr. Ct's laboratory and co-author of the study. "With our recent findings, we demonstrated that the ELMO protein closes in on itself to enter a repressed state, thus preventing the activation of the DOCK180/Rac pathway."

"Our team identified three regions in ELMO that allow it to toggle between a closed/inactive and open/active shape," adds Dr. Yoran Margaron, a postdoctoral fellow in the same research unit and one of the article's co-authors. "We showed that if we disrupt ELMO's regulatory feature and maintain the protein in an open state, we can fully activate the DOCK180/Rac pathway and significantly increase the migration potential of cells."

The researchers' next step is to investigate the regulation of ELMO in cancer cells. Based on their latest findings, they will attempt to maintain ELMO in a repressed state within cancer cells to prevent metastasis, which could have a major impact on the development of potential cancer treatments.


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Sea Grant report synthesizes recent research on New Yorks clams
2. Recent news reports of sweetener reformulations raise questions about motivations
3. Autism Speaks responds to recent publications citing autism clusters in California
4. Arctic lake sediments show warming, unique ecological changes in recent decades
5. Ongoing human evolution could explain recent rise in certain disorders
6. Recently analyzed fossil was not human ancestor as claimed, anthropologists say
7. BIO-key(R) International Biometric Accuracy Improved by More Than 23% as Reported in Recent NIST Testing
8. At opening of XVIII International AIDS Conference, scientific, community and political leaders applaud recent progress toward universal access and urge continued momentum to finish what weve started
9. Risk of surgery for Crohns disease lower than reported in recent studies
10. Breakthrough optical technology to assess colon cancer risk, accuracy
11. Sandia, SES win Popular Mechanics Breakthrough Innovator Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
Breaking Biology Technology: